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Assay Detail

CHEMBL2363630

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Functional
SANGER: Inhibition of human SF126 cell growth in a cell viability assay.
ChEMBL ↗
139
Total Activities
137
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type SF-126
Confidence 1 — Organism
Curated By Autocuration

Target

SF-126 (CHEMBL614905) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute

· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 139 5.62 9.15

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL325041 BORTEZOMIB 3.0 1 9.15
CHEMBL1972860 ELESCLOMOL 3.0 1 8.71
CHEMBL65 CAMPTOTHECIN -1.0 1 8.55
CHEMBL3545252 DOCETAXEL 4.0 1 8.48
CHEMBL94657 PATUPILONE 3.0 1 8.46
CHEMBL888 GEMCITABINE 4.0 1 8.15
CHEMBL1879463 DACTOLISIB 3.0 1 7.71
CHEMBL159 VINBLASTINE 4.0 1 7.66
CHEMBL1201182 TEMSIROLIMUS 4.0 1 7.64
CHEMBL413 SIROLIMUS 4.0 1 7.52
CHEMBL96926 THAPSIGARGIN — 1 7.42
CHEMBL1256459 TORIN1 — 1 7.36
CHEMBL252164 LUMINESPIB 2.0 1 7.30
CHEMBL217354 — — 1 7.24
CHEMBL428647 PACLITAXEL 4.0 1 7.21
CHEMBL53463 DOXORUBICIN 4.0 1 6.98
CHEMBL300389 — — 1 6.87
CHEMBL514499 GW843682X — 1 6.86
CHEMBL1171837 PONATINIB 4.0 1 6.77
CHEMBL608533 MIDOSTAURIN 4.0 1 6.61
CHEMBL513909 BI-2536 2.0 1 6.59
CHEMBL2107358 OBATOCLAX MESYLATE 3.0 1 6.56
CHEMBL603469 LESTAURTINIB 3.0 1 6.56
CHEMBL449158 BRYOSTATIN 1 2.0 1 6.53
CHEMBL379300 A-443654 — 1 6.51
CHEMBL5416410 DASATINIB 4.0 1 6.45
CHEMBL553025 VINORELBINE 4.0 1 6.34
CHEMBL2041933 AZD-7762 1.0 1 6.24
CHEMBL803 CYTARABINE 4.0 1 6.16
CHEMBL9470 SHIKONIN — 1 6.11

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL325041 BORTEZOMIB IC50 = 0.7013 nM 9.15
CHEMBL1972860 ELESCLOMOL IC50 = 1.954 nM 8.71
CHEMBL65 CAMPTOTHECIN IC50 = 2.835 nM 8.55
CHEMBL3545252 DOCETAXEL IC50 = 3.292 nM 8.48
CHEMBL94657 PATUPILONE IC50 = 3.466 nM 8.46
CHEMBL888 GEMCITABINE IC50 = 7.054 nM 8.15
CHEMBL1879463 DACTOLISIB IC50 = 19.41 nM 7.71
CHEMBL159 VINBLASTINE IC50 = 21.9 nM 7.66
CHEMBL1201182 TEMSIROLIMUS IC50 = 22.85 nM 7.64
CHEMBL413 SIROLIMUS IC50 = 30.38 nM 7.52
CHEMBL96926 THAPSIGARGIN IC50 = 38.31 nM 7.42
CHEMBL1256459 TORIN1 IC50 = 43.61 nM 7.36
CHEMBL252164 LUMINESPIB IC50 = 50.1 nM 7.30
CHEMBL217354 — IC50 = 57.07 nM 7.24
CHEMBL428647 PACLITAXEL IC50 = 61.33 nM 7.21
CHEMBL53463 DOXORUBICIN IC50 = 104.58 nM 6.98
CHEMBL300389 — IC50 = 134.48 nM 6.87
CHEMBL514499 GW843682X IC50 = 137.75 nM 6.86
CHEMBL1171837 PONATINIB IC50 = 170.63 nM 6.77
CHEMBL608533 MIDOSTAURIN IC50 = 247.31 nM 6.61
CHEMBL513909 BI-2536 IC50 = 253.83 nM 6.59
CHEMBL603469 LESTAURTINIB IC50 = 273.1 nM 6.56
CHEMBL2107358 OBATOCLAX MESYLATE IC50 = 273.02 nM 6.56
CHEMBL449158 BRYOSTATIN 1 IC50 = 293.56 nM 6.53
CHEMBL379300 A-443654 IC50 = 310.74 nM 6.51
CHEMBL5416410 DASATINIB IC50 = 354.1 nM 6.45
CHEMBL553025 VINORELBINE IC50 = 459.23 nM 6.34
CHEMBL2041933 AZD-7762 IC50 = 574.21 nM 6.24
CHEMBL803 CYTARABINE IC50 = 693.17 nM 6.16
CHEMBL9470 SHIKONIN IC50 = 772.97 nM 6.11
CHEMBL1801204 AZD-8055 IC50 = 887.14 nM 6.05
CHEMBL572878 TOZASERTIB IC50 = 948.19 nM 6.02
CHEMBL64925 MG-132 IC50 = 989.71 nM 6.00
CHEMBL509032 TAE-684 IC50 = 1115.68 nM 5.95
CHEMBL105 MITOMYCIN IC50 = 1405.65 nM 5.85
CHEMBL44657 ETOPOSIDE IC50 = 1440.86 nM 5.84
CHEMBL575448 BMS-754807 IC50 = 1550.86 nM 5.81
CHEMBL1336 SORAFENIB IC50 = 1638.12 nM 5.79
CHEMBL213100 — IC50 = 1731.78 nM 5.76
CHEMBL521851 PICTILISIB IC50 = 2306.25 nM 5.64
CHEMBL27759 ENTINOSTAT IC50 = 2330.94 nM 5.63
CHEMBL401930 — IC50 = 2472.96 nM 5.61
CHEMBL577784 BX-795 IC50 = 2436.21 nM 5.61
CHEMBL477772 PAZOPANIB IC50 = 2474.59 nM 5.61
CHEMBL379975 — IC50 = 2497.99 nM 5.60
CHEMBL392695 S-TRITYL-L-CYSTEINE IC50 = 3012.55 nM 5.52
CHEMBL6067492 BLEOMYCIN IC50 = 3089.14 nM 5.51
CHEMBL535 SUNITINIB IC50 = 3061.98 nM 5.51
CHEMBL585951 — IC50 = 3163.11 nM 5.50
CHEMBL217092 SARACATINIB IC50 = 3311.74 nM 5.48