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Assay Detail

CHEMBL2363633

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Functional
SANGER: Inhibition of human SF539 cell growth in a cell viability assay.
ChEMBL ↗
139
Total Activities
137
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type SF-539
Confidence 1 — Organism
Curated By Autocuration

Target

SF-539 (CHEMBL614860) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute

· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 139 5.82 10.94

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL413 SIROLIMUS 4.0 1 10.94
CHEMBL3545252 DOCETAXEL 4.0 1 9.52
CHEMBL509032 TAE-684 — 1 9.25
CHEMBL888 GEMCITABINE 4.0 1 8.99
CHEMBL159 VINBLASTINE 4.0 1 8.92
CHEMBL96926 THAPSIGARGIN — 1 8.71
CHEMBL94657 PATUPILONE 3.0 1 8.64
CHEMBL65 CAMPTOTHECIN -1.0 1 8.04
CHEMBL553025 VINORELBINE 4.0 1 7.85
CHEMBL325041 BORTEZOMIB 3.0 1 7.68
CHEMBL428647 PACLITAXEL 4.0 1 7.62
CHEMBL1972860 ELESCLOMOL 3.0 1 7.61
CHEMBL1879463 DACTOLISIB 3.0 1 7.28
CHEMBL109480 TANESPIMYCIN 3.0 1 7.17
CHEMBL2107358 OBATOCLAX MESYLATE 3.0 1 6.93
CHEMBL53463 DOXORUBICIN 4.0 1 6.92
CHEMBL1201182 TEMSIROLIMUS 4.0 1 6.92
CHEMBL105 MITOMYCIN 4.0 1 6.90
CHEMBL2041933 AZD-7762 1.0 1 6.86
CHEMBL603469 LESTAURTINIB 3.0 1 6.76
CHEMBL27759 ENTINOSTAT 3.0 1 6.71
CHEMBL601719 CRIZOTINIB 4.0 1 6.69
CHEMBL300389 — — 1 6.50
CHEMBL514499 GW843682X — 1 6.47
CHEMBL6067492 BLEOMYCIN 4.0 1 6.41
CHEMBL217354 — — 1 6.33
CHEMBL513909 BI-2536 2.0 1 6.31
CHEMBL585951 — — 1 6.17
CHEMBL507361 MIRDAMETINIB 2.0 1 6.17
CHEMBL803 CYTARABINE 4.0 1 6.14

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL413 SIROLIMUS IC50 = 0.0116 nM 10.94
CHEMBL3545252 DOCETAXEL IC50 = 0.302 nM 9.52
CHEMBL509032 TAE-684 IC50 = 0.5643 nM 9.25
CHEMBL888 GEMCITABINE IC50 = 1.023 nM 8.99
CHEMBL159 VINBLASTINE IC50 = 1.211 nM 8.92
CHEMBL96926 THAPSIGARGIN IC50 = 1.945 nM 8.71
CHEMBL94657 PATUPILONE IC50 = 2.271 nM 8.64
CHEMBL65 CAMPTOTHECIN IC50 = 9.009 nM 8.04
CHEMBL553025 VINORELBINE IC50 = 14.1 nM 7.85
CHEMBL325041 BORTEZOMIB IC50 = 20.67 nM 7.68
CHEMBL428647 PACLITAXEL IC50 = 24.01 nM 7.62
CHEMBL1972860 ELESCLOMOL IC50 = 24.37 nM 7.61
CHEMBL1879463 DACTOLISIB IC50 = 52.35 nM 7.28
CHEMBL109480 TANESPIMYCIN IC50 = 66.81 nM 7.17
CHEMBL2107358 OBATOCLAX MESYLATE IC50 = 116.16 nM 6.93
CHEMBL53463 DOXORUBICIN IC50 = 121.72 nM 6.92
CHEMBL1201182 TEMSIROLIMUS IC50 = 120.88 nM 6.92
CHEMBL105 MITOMYCIN IC50 = 127.02 nM 6.90
CHEMBL2041933 AZD-7762 IC50 = 136.8 nM 6.86
CHEMBL603469 LESTAURTINIB IC50 = 174.57 nM 6.76
CHEMBL27759 ENTINOSTAT IC50 = 195.93 nM 6.71
CHEMBL601719 CRIZOTINIB IC50 = 204.24 nM 6.69
CHEMBL300389 — IC50 = 319.73 nM 6.50
CHEMBL514499 GW843682X IC50 = 336.47 nM 6.47
CHEMBL6067492 BLEOMYCIN IC50 = 393.05 nM 6.41
CHEMBL217354 — IC50 = 470.14 nM 6.33
CHEMBL513909 BI-2536 IC50 = 486.84 nM 6.31
CHEMBL585951 — IC50 = 672.91 nM 6.17
CHEMBL507361 MIRDAMETINIB IC50 = 672.62 nM 6.17
CHEMBL803 CYTARABINE IC50 = 716.77 nM 6.14
CHEMBL449158 BRYOSTATIN 1 IC50 = 747.04 nM 6.13
CHEMBL252164 LUMINESPIB IC50 = 799.25 nM 6.10
CHEMBL9470 SHIKONIN IC50 = 856.82 nM 6.07
CHEMBL1256459 TORIN1 IC50 = 983.96 nM 6.01
CHEMBL379975 — IC50 = 1248.14 nM 5.90
CHEMBL220241 GSK-269962A IC50 = 1286.61 nM 5.89
CHEMBL1801204 AZD-8055 IC50 = 1579.69 nM 5.80
CHEMBL44657 ETOPOSIDE IC50 = 1606.89 nM 5.79
CHEMBL392695 S-TRITYL-L-CYSTEINE IC50 = 2062.06 nM 5.69
CHEMBL3349342 — IC50 = 2210.77 nM 5.66
CHEMBL4298697 — IC50 = 2473.02 nM 5.61
CHEMBL36 PYRIMETHAMINE IC50 = 2546.06 nM 5.59
CHEMBL11359 CISPLATIN IC50 = 3526.52 nM 5.45
CHEMBL577784 BX-795 IC50 = 3742.45 nM 5.43
CHEMBL379300 A-443654 IC50 = 3793.07 nM 5.42
CHEMBL1336 SORAFENIB IC50 = 5132.27 nM 5.29
CHEMBL1171837 PONATINIB IC50 = 5099.59 nM 5.29
CHEMBL98 VORINOSTAT IC50 = 5266.32 nM 5.28
CHEMBL575448 BMS-754807 IC50 = 5813.09 nM 5.24
CHEMBL521851 PICTILISIB IC50 = 6993.33 nM 5.16