Assay Detail
Functional
CHEMBL2363634
Review assay metadata, readout intent, target linkage, and publication context from the same page.
SANGER: Inhibition of human SH-4 cell growth in a cell viability assay.
139
Total Activities
137
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SH-4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 139 | 5.82 | 9.76 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 9.76 |
| CHEMBL2144069 | — | — | 1 | 8.52 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 8.49 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 8.38 |
| CHEMBL413 | SIROLIMUS | 4.0 | 1 | 8.36 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 8.11 |
| CHEMBL507361 | MIRDAMETINIB | 2.0 | 1 | 8.08 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 8.04 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 7.81 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 7.75 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 7.72 |
| CHEMBL1256459 | TORIN1 | — | 1 | 7.45 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 7.38 |
| CHEMBL64925 | MG-132 | — | 2 | 7.37 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 7.36 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 7.22 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 7.12 |
| CHEMBL3349342 | — | — | 1 | 7.07 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.04 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 6.96 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 6.95 |
| CHEMBL514499 | GW843682X | — | 1 | 6.91 |
| CHEMBL513909 | BI-2536 | 2.0 | 1 | 6.81 |
| CHEMBL1614701 | SELUMETINIB | 4.0 | 1 | 6.78 |
| CHEMBL5416410 | DASATINIB | 4.0 | 1 | 6.74 |
| CHEMBL379300 | A-443654 | — | 1 | 6.73 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 6.70 |
| CHEMBL217354 | — | — | 1 | 6.64 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 6.63 |
| CHEMBL300389 | — | — | 1 | 6.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 0.1727 | nM | 9.76 |
| CHEMBL2144069 | — | IC50 | = | 3.009 | nM | 8.52 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 3.224 | nM | 8.49 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 4.173 | nM | 8.38 |
| CHEMBL413 | SIROLIMUS | IC50 | = | 4.34 | nM | 8.36 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 7.728 | nM | 8.11 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 8.26 | nM | 8.08 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 9.022 | nM | 8.04 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 15.52 | nM | 7.81 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 17.77 | nM | 7.75 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 18.95 | nM | 7.72 |
| CHEMBL1256459 | TORIN1 | IC50 | = | 35.82 | nM | 7.45 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 41.41 | nM | 7.38 |
| CHEMBL64925 | MG-132 | IC50 | = | 43.1 | nM | 7.37 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 43.54 | nM | 7.36 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 59.8 | nM | 7.22 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 75.21 | nM | 7.12 |
| CHEMBL3349342 | — | IC50 | = | 85.61 | nM | 7.07 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 92.11 | nM | 7.04 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 110.39 | nM | 6.96 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 113.56 | nM | 6.95 |
| CHEMBL514499 | GW843682X | IC50 | = | 122.79 | nM | 6.91 |
| CHEMBL513909 | BI-2536 | IC50 | = | 154.66 | nM | 6.81 |
| CHEMBL1614701 | SELUMETINIB | IC50 | = | 166.48 | nM | 6.78 |
| CHEMBL5416410 | DASATINIB | IC50 | = | 184.13 | nM | 6.74 |
| CHEMBL379300 | A-443654 | IC50 | = | 184.99 | nM | 6.73 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 199.45 | nM | 6.70 |
| CHEMBL217354 | — | IC50 | = | 226.83 | nM | 6.64 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 232.64 | nM | 6.63 |
| CHEMBL300389 | — | IC50 | = | 337.88 | nM | 6.47 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 371.35 | nM | 6.43 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 387.26 | nM | 6.41 |
| CHEMBL585951 | — | IC50 | = | 410.34 | nM | 6.39 |
| CHEMBL1230020 | PLX-4720 | IC50 | = | 414.22 | nM | 6.38 |
| CHEMBL105442 | CI-1040 | IC50 | = | 462.56 | nM | 6.33 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 492.71 | nM | 6.31 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 541.15 | nM | 6.27 |
| CHEMBL64925 | MG-132 | IC50 | = | 605.09 | nM | 6.22 |
| CHEMBL1336 | SORAFENIB | IC50 | = | 656.13 | nM | 6.18 |
| CHEMBL477989 | SB590885 | IC50 | = | 811.92 | nM | 6.09 |
| CHEMBL401930 | — | IC50 | = | 881.59 | nM | 6.05 |
| CHEMBL197603 | — | IC50 | = | 912.81 | nM | 6.04 |
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 1024.1 | nM | 5.99 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 1022.44 | nM | 5.99 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 1084.31 | nM | 5.96 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 1304.89 | nM | 5.88 |
| CHEMBL2363137 | — | IC50 | = | 1384.82 | nM | 5.86 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 1628.51 | nM | 5.79 |
| CHEMBL379975 | — | IC50 | = | 1646.32 | nM | 5.78 |
| CHEMBL1673039 | — | IC50 | = | 1990.09 | nM | 5.70 |