Assay Detail
Functional
CHEMBL2363645
Review assay metadata, readout intent, target linkage, and publication context from the same page.
SANGER: Inhibition of human SK-MEL-2 cell growth in a cell viability assay.
139
Total Activities
137
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-MEL-2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 139 | 5.64 | 9.53 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 9.53 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 8.77 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 8.14 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 8.14 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 7.57 |
| CHEMBL507361 | MIRDAMETINIB | 2.0 | 1 | 7.45 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 7.27 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 7.26 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 7.14 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 7.12 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 7.04 |
| CHEMBL3349342 | — | — | 1 | 7.00 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 7.00 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 6.90 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 6.80 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 6.67 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.64 |
| CHEMBL217354 | — | — | 1 | 6.64 |
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 6.55 |
| CHEMBL1614701 | SELUMETINIB | 4.0 | 1 | 6.39 |
| CHEMBL575448 | BMS-754807 | 2.0 | 1 | 6.38 |
| CHEMBL1256459 | TORIN1 | — | 1 | 6.33 |
| CHEMBL289228 | TIPIFARNIB | 3.0 | 1 | 6.32 |
| CHEMBL300389 | — | — | 1 | 6.30 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 6.22 |
| CHEMBL585951 | — | — | 1 | 6.20 |
| CHEMBL1801204 | AZD-8055 | 1.0 | 1 | 6.19 |
| CHEMBL477989 | SB590885 | — | 1 | 6.13 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.09 |
| CHEMBL379300 | A-443654 | — | 1 | 6.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 0.2947 | nM | 9.53 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 1.701 | nM | 8.77 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 7.183 | nM | 8.14 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 7.191 | nM | 8.14 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 26.65 | nM | 7.57 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 35.2 | nM | 7.45 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 53.3 | nM | 7.27 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 54.75 | nM | 7.26 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 73.16 | nM | 7.14 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 76.75 | nM | 7.12 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 90.6 | nM | 7.04 |
| CHEMBL3349342 | — | IC50 | = | 100.85 | nM | 7.00 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 100.33 | nM | 7.00 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 124.6 | nM | 6.90 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 156.68 | nM | 6.80 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 212.25 | nM | 6.67 |
| CHEMBL217354 | — | IC50 | = | 230.19 | nM | 6.64 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 230.3 | nM | 6.64 |
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 281.9 | nM | 6.55 |
| CHEMBL1614701 | SELUMETINIB | IC50 | = | 405.06 | nM | 6.39 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 418.05 | nM | 6.38 |
| CHEMBL1256459 | TORIN1 | IC50 | = | 464.0 | nM | 6.33 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 483.73 | nM | 6.32 |
| CHEMBL300389 | — | IC50 | = | 497.92 | nM | 6.30 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 601.78 | nM | 6.22 |
| CHEMBL585951 | — | IC50 | = | 631.03 | nM | 6.20 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 641.53 | nM | 6.19 |
| CHEMBL477989 | SB590885 | IC50 | = | 737.55 | nM | 6.13 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 809.44 | nM | 6.09 |
| CHEMBL379300 | A-443654 | IC50 | = | 832.58 | nM | 6.08 |
| CHEMBL514499 | GW843682X | IC50 | = | 898.19 | nM | 6.05 |
| CHEMBL105442 | CI-1040 | IC50 | = | 1574.59 | nM | 5.80 |
| CHEMBL2363137 | — | IC50 | = | 1717.77 | nM | 5.76 |
| CHEMBL513909 | BI-2536 | IC50 | = | 1717.89 | nM | 5.76 |
| CHEMBL1190711 | — | IC50 | = | 1893.72 | nM | 5.72 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 1902.71 | nM | 5.72 |
| CHEMBL379975 | — | IC50 | = | 2225.54 | nM | 5.65 |
| CHEMBL288441 | BOSUTINIB | IC50 | = | 2892.43 | nM | 5.54 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 2970.03 | nM | 5.53 |
| CHEMBL2144069 | — | IC50 | = | 3217.51 | nM | 5.49 |
| CHEMBL577784 | BX-795 | IC50 | = | 4020.08 | nM | 5.40 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 3974.64 | nM | 5.40 |
| CHEMBL803 | CYTARABINE | IC50 | = | 4028.1 | nM | 5.39 |
| CHEMBL413 | SIROLIMUS | IC50 | = | 4869.55 | nM | 5.31 |
| CHEMBL393929 | — | IC50 | = | 5096.32 | nM | 5.29 |
| CHEMBL412142 | LADUVIGLUSIB | IC50 | = | 6383.44 | nM | 5.20 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 6328.9 | nM | 5.20 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 7130.94 | nM | 5.15 |
| CHEMBL1091644 | LINSITINIB | IC50 | = | 7483.73 | nM | 5.13 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 8485.48 | nM | 5.07 |