Assay Detail
Functional
CHEMBL2363648
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SANGER: Inhibition of human SK-MEL-3 cell growth in a cell viability assay.
99
Total Activities
98
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-MEL-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 99 | 5.58 | 8.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 8.58 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 8.19 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 7.76 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 7.68 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 7.32 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 7.24 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 6.98 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.83 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 6.83 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 6.80 |
| CHEMBL575448 | BMS-754807 | 2.0 | 1 | 6.59 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 6.48 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 6.30 |
| CHEMBL1230020 | PLX-4720 | — | 1 | 6.29 |
| CHEMBL507361 | MIRDAMETINIB | 2.0 | 1 | 6.22 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 6.18 |
| CHEMBL217354 | — | — | 1 | 6.16 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 6.15 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 6.14 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 6.09 |
| CHEMBL477989 | SB590885 | — | 1 | 6.09 |
| CHEMBL585951 | — | — | 1 | 6.06 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 5.98 |
| CHEMBL608533 | MIDOSTAURIN | 4.0 | 1 | 5.90 |
| CHEMBL1801204 | AZD-8055 | 1.0 | 1 | 5.90 |
| CHEMBL379975 | — | — | 1 | 5.88 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 5.84 |
| CHEMBL1091644 | LINSITINIB | 3.0 | 1 | 5.83 |
| CHEMBL1090771 | AVAGACESTAT | 2.0 | 1 | 5.82 |
| CHEMBL1171837 | PONATINIB | 4.0 | 1 | 5.79 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 2.641 | nM | 8.58 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 6.514 | nM | 8.19 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 17.33 | nM | 7.76 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 20.88 | nM | 7.68 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 48.02 | nM | 7.32 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 57.88 | nM | 7.24 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 105.1 | nM | 6.98 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 147.61 | nM | 6.83 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 147.55 | nM | 6.83 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 159.53 | nM | 6.80 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 258.34 | nM | 6.59 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 329.41 | nM | 6.48 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 506.39 | nM | 6.30 |
| CHEMBL1230020 | PLX-4720 | IC50 | = | 515.68 | nM | 6.29 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 604.72 | nM | 6.22 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 661.12 | nM | 6.18 |
| CHEMBL217354 | — | IC50 | = | 692.57 | nM | 6.16 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 711.12 | nM | 6.15 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 717.01 | nM | 6.14 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 815.08 | nM | 6.09 |
| CHEMBL477989 | SB590885 | IC50 | = | 817.69 | nM | 6.09 |
| CHEMBL585951 | — | IC50 | = | 876.94 | nM | 6.06 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 1055.93 | nM | 5.98 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 1263.72 | nM | 5.90 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 1247.76 | nM | 5.90 |
| CHEMBL379975 | — | IC50 | = | 1308.59 | nM | 5.88 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 1429.51 | nM | 5.84 |
| CHEMBL1091644 | LINSITINIB | IC50 | = | 1485.56 | nM | 5.83 |
| CHEMBL1090771 | AVAGACESTAT | IC50 | = | 1499.22 | nM | 5.82 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 1639.02 | nM | 5.79 |
| CHEMBL1614701 | SELUMETINIB | IC50 | = | 1950.77 | nM | 5.71 |
| CHEMBL188678 | — | IC50 | = | 2164.9 | nM | 5.67 |
| CHEMBL3349342 | — | IC50 | = | 2464.12 | nM | 5.61 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 2642.21 | nM | 5.58 |
| CHEMBL591429 | PAC-1 | IC50 | = | 2764.02 | nM | 5.56 |
| CHEMBL2137530 | SERDEMETAN | IC50 | = | 3312.07 | nM | 5.48 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 3532.14 | nM | 5.45 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 3828.41 | nM | 5.42 |
| CHEMBL105442 | CI-1040 | IC50 | = | 3851.54 | nM | 5.41 |
| CHEMBL2363137 | — | IC50 | = | 4679.6 | nM | 5.33 |
| CHEMBL1190711 | — | IC50 | = | 5056.67 | nM | 5.30 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 4977.67 | nM | 5.30 |
| CHEMBL189584 | PD-173074 | IC50 | = | 5240.6 | nM | 5.28 |
| CHEMBL443684 | NAVITOCLAX | IC50 | = | 6429.15 | nM | 5.19 |
| CHEMBL1186585 | — | IC50 | = | 6911.43 | nM | 5.16 |
| CHEMBL202721 | — | IC50 | = | 7680.11 | nM | 5.12 |
| CHEMBL240954 | — | IC50 | = | 7738.35 | nM | 5.11 |
| CHEMBL222102 | KU-55933 | IC50 | = | 8285.75 | nM | 5.08 |
| CHEMBL2165191 | AZD-6482 | IC50 | = | 9477.29 | nM | 5.02 |
| CHEMBL409 | BICALUTAMIDE | IC50 | = | 10096.43 | nM | 5.00 |