Assay Detail
Functional
CHEMBL2363655
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SANGER: Inhibition of human SK-N-DZ cell growth in a cell viability assay.
139
Total Activities
137
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-N-DZ |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 139 | 5.37 | 8.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 8.49 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 8.12 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 8.01 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 7.66 |
| CHEMBL514499 | GW843682X | — | 1 | 7.43 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 7.43 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 7.37 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 7.14 |
| CHEMBL575448 | BMS-754807 | 2.0 | 1 | 7.11 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 7.06 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 6.94 |
| CHEMBL1256459 | TORIN1 | — | 1 | 6.83 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 6.75 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 6.72 |
| CHEMBL217354 | — | — | 1 | 6.68 |
| CHEMBL1091644 | LINSITINIB | 3.0 | 1 | 6.62 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 6.60 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 6.59 |
| CHEMBL300389 | — | — | 1 | 6.35 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 6.28 |
| CHEMBL572881 | MOTESANIB | 3.0 | 1 | 6.26 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 6.13 |
| CHEMBL512504 | — | — | 1 | 6.10 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 6.07 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.05 |
| CHEMBL572878 | TOZASERTIB | 2.0 | 1 | 6.02 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 6.00 |
| CHEMBL803 | CYTARABINE | 4.0 | 1 | 5.97 |
| CHEMBL507361 | MIRDAMETINIB | 2.0 | 1 | 5.96 |
| CHEMBL27759 | ENTINOSTAT | 3.0 | 1 | 5.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 3.259 | nM | 8.49 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 7.593 | nM | 8.12 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 9.828 | nM | 8.01 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 21.69 | nM | 7.66 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 37.37 | nM | 7.43 |
| CHEMBL514499 | GW843682X | IC50 | = | 37.44 | nM | 7.43 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 43.19 | nM | 7.37 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 73.07 | nM | 7.14 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 77.92 | nM | 7.11 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 86.56 | nM | 7.06 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 113.97 | nM | 6.94 |
| CHEMBL1256459 | TORIN1 | IC50 | = | 147.19 | nM | 6.83 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 178.83 | nM | 6.75 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 189.27 | nM | 6.72 |
| CHEMBL217354 | — | IC50 | = | 206.81 | nM | 6.68 |
| CHEMBL1091644 | LINSITINIB | IC50 | = | 236.98 | nM | 6.62 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 249.04 | nM | 6.60 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 258.07 | nM | 6.59 |
| CHEMBL300389 | — | IC50 | = | 445.89 | nM | 6.35 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 530.78 | nM | 6.28 |
| CHEMBL572881 | MOTESANIB | IC50 | = | 549.04 | nM | 6.26 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 743.08 | nM | 6.13 |
| CHEMBL512504 | — | IC50 | = | 802.31 | nM | 6.10 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 859.43 | nM | 6.07 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 900.43 | nM | 6.05 |
| CHEMBL572878 | TOZASERTIB | IC50 | = | 961.89 | nM | 6.02 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 997.75 | nM | 6.00 |
| CHEMBL803 | CYTARABINE | IC50 | = | 1072.13 | nM | 5.97 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 1103.54 | nM | 5.96 |
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 1247.76 | nM | 5.90 |
| CHEMBL939 | GEFITINIB | IC50 | = | 1369.47 | nM | 5.86 |
| CHEMBL509032 | TAE-684 | IC50 | = | 1783.09 | nM | 5.75 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 1803.2 | nM | 5.74 |
| CHEMBL217092 | SARACATINIB | IC50 | = | 1846.88 | nM | 5.73 |
| CHEMBL585951 | — | IC50 | = | 1856.94 | nM | 5.73 |
| CHEMBL393929 | — | IC50 | = | 2018.76 | nM | 5.70 |
| CHEMBL477772 | PAZOPANIB | IC50 | = | 2023.81 | nM | 5.69 |
| CHEMBL401930 | — | IC50 | = | 2110.03 | nM | 5.68 |
| CHEMBL413 | SIROLIMUS | IC50 | = | 2132.74 | nM | 5.67 |
| CHEMBL259181 | — | IC50 | = | 2226.16 | nM | 5.65 |
| CHEMBL2165191 | AZD-6482 | IC50 | = | 2323.12 | nM | 5.63 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 2389.58 | nM | 5.62 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 2565.92 | nM | 5.59 |
| CHEMBL288441 | BOSUTINIB | IC50 | = | 2816.38 | nM | 5.55 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 2863.81 | nM | 5.54 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 3050.75 | nM | 5.52 |
| CHEMBL392695 | S-TRITYL-L-CYSTEINE | IC50 | = | 3144.51 | nM | 5.50 |
| CHEMBL2137530 | SERDEMETAN | IC50 | = | 3625.95 | nM | 5.44 |
| CHEMBL535 | SUNITINIB | IC50 | = | 4670.99 | nM | 5.33 |
| CHEMBL4298697 | — | IC50 | = | 4651.78 | nM | 5.33 |