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Assay Detail

CHEMBL2363671

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Functional
SANGER: Inhibition of human SNU-C2B cell growth in a cell viability assay.
ChEMBL ↗
124
Total Activities
123
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type SNU-C2B
Confidence 1 — Organism
Curated By Autocuration

Target

SNU-C2B (CHEMBL2366279) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute

· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 124 5.49 8.37

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL94657 PATUPILONE 3.0 1 8.37
CHEMBL514499 GW843682X — 1 8.12
CHEMBL553025 VINORELBINE 4.0 1 8.11
CHEMBL96926 THAPSIGARGIN — 1 7.91
CHEMBL252164 LUMINESPIB 2.0 1 7.90
CHEMBL428647 PACLITAXEL 4.0 1 7.83
CHEMBL513909 BI-2536 2.0 1 7.82
CHEMBL159 VINBLASTINE 4.0 1 7.61
CHEMBL3545252 DOCETAXEL 4.0 1 7.51
CHEMBL65 CAMPTOTHECIN -1.0 1 7.45
CHEMBL300389 — — 1 6.98
CHEMBL449158 BRYOSTATIN 1 2.0 1 6.98
CHEMBL34259 METHOTREXATE 4.0 1 6.84
CHEMBL1879463 DACTOLISIB 3.0 1 6.74
CHEMBL1972860 ELESCLOMOL 3.0 1 6.64
CHEMBL1256459 TORIN1 — 1 6.61
CHEMBL217354 — — 1 6.59
CHEMBL2041933 AZD-7762 1.0 1 6.55
CHEMBL379300 A-443654 — 1 6.54
CHEMBL105 MITOMYCIN 4.0 1 6.53
CHEMBL53463 DOXORUBICIN 4.0 1 6.34
CHEMBL507361 MIRDAMETINIB 2.0 1 6.31
CHEMBL109480 TANESPIMYCIN 3.0 1 6.24
CHEMBL585951 — — 1 6.20
CHEMBL64925 MG-132 — 1 6.15
CHEMBL1201182 TEMSIROLIMUS 4.0 1 6.13
CHEMBL2107358 OBATOCLAX MESYLATE 3.0 1 6.06
CHEMBL603469 LESTAURTINIB 3.0 1 5.95
CHEMBL392695 S-TRITYL-L-CYSTEINE — 1 5.89
CHEMBL5416410 DASATINIB 4.0 1 5.88

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL94657 PATUPILONE IC50 = 4.297 nM 8.37
CHEMBL514499 GW843682X IC50 = 7.531 nM 8.12
CHEMBL553025 VINORELBINE IC50 = 7.749 nM 8.11
CHEMBL96926 THAPSIGARGIN IC50 = 12.43 nM 7.91
CHEMBL252164 LUMINESPIB IC50 = 12.72 nM 7.90
CHEMBL428647 PACLITAXEL IC50 = 14.96 nM 7.83
CHEMBL513909 BI-2536 IC50 = 15.26 nM 7.82
CHEMBL159 VINBLASTINE IC50 = 24.67 nM 7.61
CHEMBL3545252 DOCETAXEL IC50 = 30.63 nM 7.51
CHEMBL65 CAMPTOTHECIN IC50 = 35.38 nM 7.45
CHEMBL300389 — IC50 = 103.97 nM 6.98
CHEMBL449158 BRYOSTATIN 1 IC50 = 105.25 nM 6.98
CHEMBL34259 METHOTREXATE IC50 = 144.74 nM 6.84
CHEMBL1879463 DACTOLISIB IC50 = 180.73 nM 6.74
CHEMBL1972860 ELESCLOMOL IC50 = 226.61 nM 6.64
CHEMBL1256459 TORIN1 IC50 = 243.16 nM 6.61
CHEMBL217354 — IC50 = 257.36 nM 6.59
CHEMBL2041933 AZD-7762 IC50 = 281.34 nM 6.55
CHEMBL379300 A-443654 IC50 = 290.27 nM 6.54
CHEMBL105 MITOMYCIN IC50 = 295.05 nM 6.53
CHEMBL53463 DOXORUBICIN IC50 = 460.97 nM 6.34
CHEMBL507361 MIRDAMETINIB IC50 = 492.37 nM 6.31
CHEMBL109480 TANESPIMYCIN IC50 = 579.77 nM 6.24
CHEMBL585951 — IC50 = 637.28 nM 6.20
CHEMBL64925 MG-132 IC50 = 707.39 nM 6.15
CHEMBL1201182 TEMSIROLIMUS IC50 = 742.46 nM 6.13
CHEMBL2107358 OBATOCLAX MESYLATE IC50 = 868.01 nM 6.06
CHEMBL603469 LESTAURTINIB IC50 = 1120.2 nM 5.95
CHEMBL392695 S-TRITYL-L-CYSTEINE IC50 = 1280.72 nM 5.89
CHEMBL5416410 DASATINIB IC50 = 1305.89 nM 5.88
CHEMBL888 GEMCITABINE IC50 = 1547.77 nM 5.81
CHEMBL1190711 — IC50 = 1839.12 nM 5.74
CHEMBL509032 TAE-684 IC50 = 2033.51 nM 5.69
CHEMBL1801204 AZD-8055 IC50 = 2108.23 nM 5.68
CHEMBL6067492 BLEOMYCIN IC50 = 2324.84 nM 5.63
CHEMBL1173655 AFATINIB IC50 = 2686.16 nM 5.57
CHEMBL401930 — IC50 = 2711.94 nM 5.57
CHEMBL573107 — IC50 = 3390.97 nM 5.47
CHEMBL98 VORINOSTAT IC50 = 4247.69 nM 5.37
CHEMBL2363137 — IC50 = 4285.7 nM 5.37
CHEMBL939 GEFITINIB IC50 = 4346.86 nM 5.36
CHEMBL209148 — IC50 = 4642.79 nM 5.33
CHEMBL575448 BMS-754807 IC50 = 5447.71 nM 5.26
CHEMBL2137530 SERDEMETAN IC50 = 6011.38 nM 5.22
CHEMBL379975 — IC50 = 6141.46 nM 5.21
CHEMBL413 SIROLIMUS IC50 = 6409.69 nM 5.19
CHEMBL1171837 PONATINIB IC50 = 7295.71 nM 5.14
CHEMBL217092 SARACATINIB IC50 = 7827.37 nM 5.11
CHEMBL191384 — IC50 = 7845.09 nM 5.11
CHEMBL3349342 — IC50 = 7879.02 nM 5.10