Assay Detail
Functional
CHEMBL2363678
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SANGER: Inhibition of human SW13 cell growth in a cell viability assay.
95
Total Activities
94
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SW13 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 95 | 5.62 | 8.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 8.77 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 8.52 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 8.33 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 8.30 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 8.26 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 8.11 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 8.03 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 7.34 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 7.18 |
| CHEMBL6067492 | BLEOMYCIN | 4.0 | 1 | 7.09 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.94 |
| CHEMBL1173655 | AFATINIB | 4.0 | 1 | 6.79 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 6.73 |
| CHEMBL217354 | — | — | 1 | 6.69 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 6.62 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 6.48 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 6.39 |
| CHEMBL803 | CYTARABINE | 4.0 | 1 | 6.32 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 6.21 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 6.19 |
| CHEMBL288441 | BOSUTINIB | 4.0 | 1 | 6.13 |
| CHEMBL1801204 | AZD-8055 | 1.0 | 1 | 6.01 |
| CHEMBL585951 | — | — | 1 | 5.86 |
| CHEMBL9470 | SHIKONIN | — | 1 | 5.85 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 5.74 |
| CHEMBL2363137 | — | — | 1 | 5.70 |
| CHEMBL507361 | MIRDAMETINIB | 2.0 | 1 | 5.54 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.51 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 5.49 |
| CHEMBL289228 | TIPIFARNIB | 3.0 | 1 | 5.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 1.688 | nM | 8.77 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 2.993 | nM | 8.52 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 4.717 | nM | 8.33 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 5.012 | nM | 8.30 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 5.49 | nM | 8.26 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 7.689 | nM | 8.11 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 9.382 | nM | 8.03 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 45.9 | nM | 7.34 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 66.5 | nM | 7.18 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 81.62 | nM | 7.09 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 115.26 | nM | 6.94 |
| CHEMBL1173655 | AFATINIB | IC50 | = | 162.16 | nM | 6.79 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 185.71 | nM | 6.73 |
| CHEMBL217354 | — | IC50 | = | 203.59 | nM | 6.69 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 239.95 | nM | 6.62 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 330.37 | nM | 6.48 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 406.26 | nM | 6.39 |
| CHEMBL803 | CYTARABINE | IC50 | = | 476.18 | nM | 6.32 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 617.37 | nM | 6.21 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 642.49 | nM | 6.19 |
| CHEMBL288441 | BOSUTINIB | IC50 | = | 737.98 | nM | 6.13 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 983.92 | nM | 6.01 |
| CHEMBL585951 | — | IC50 | = | 1381.29 | nM | 5.86 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 1409.19 | nM | 5.85 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 1802.03 | nM | 5.74 |
| CHEMBL2363137 | — | IC50 | = | 1987.92 | nM | 5.70 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 2873.73 | nM | 5.54 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 3078.74 | nM | 5.51 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 3232.6 | nM | 5.49 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 3601.53 | nM | 5.44 |
| CHEMBL3349342 | — | IC50 | = | 4325.84 | nM | 5.36 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 4871.46 | nM | 5.31 |
| CHEMBL939 | GEFITINIB | IC50 | = | 5532.65 | nM | 5.26 |
| CHEMBL1186585 | — | IC50 | = | 6470.47 | nM | 5.19 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 6544.51 | nM | 5.18 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 8043.7 | nM | 5.09 |
| CHEMBL2137530 | SERDEMETAN | IC50 | = | 8151.7 | nM | 5.09 |
| CHEMBL191384 | — | IC50 | = | 10600.36 | nM | 4.97 |
| CHEMBL1084546 | PF-00562271 | IC50 | = | 10637.36 | nM | 4.97 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 12154.11 | nM | 4.92 |
| CHEMBL135561 | — | IC50 | = | 11906.08 | nM | 4.92 |
| CHEMBL2134202 | — | IC50 | = | 11931.88 | nM | 4.92 |
| CHEMBL221137 | EMBELIN | IC50 | = | 12557.21 | nM | 4.90 |
| CHEMBL105442 | CI-1040 | IC50 | = | 13116.5 | nM | 4.88 |
| CHEMBL11359 | CISPLATIN | IC50 | = | 14308.49 | nM | 4.84 |
| CHEMBL1091644 | LINSITINIB | IC50 | = | 15618.05 | nM | 4.81 |
| CHEMBL2165191 | AZD-6482 | IC50 | = | 15639.69 | nM | 4.81 |
| CHEMBL259181 | — | IC50 | = | 16222.24 | nM | 4.79 |
| CHEMBL399530 | — | IC50 | = | 17977.12 | nM | 4.75 |
| CHEMBL379975 | — | IC50 | = | 21212.17 | nM | 4.67 |