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Assay Detail

CHEMBL2363682

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Functional
SANGER: Inhibition of human SW1710 cell growth in a cell viability assay.
ChEMBL ↗
99
Total Activities
98
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type SW1710
Confidence 1 — Organism
Curated By Autocuration

Target

SW1710 (CHEMBL1075590) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute

· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 99 5.96 10.67

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL94657 PATUPILONE 3.0 1 10.67
CHEMBL888 GEMCITABINE 4.0 1 10.12
CHEMBL96926 THAPSIGARGIN — 1 9.82
CHEMBL3545252 DOCETAXEL 4.0 1 9.33
CHEMBL252164 LUMINESPIB 2.0 1 8.73
CHEMBL553025 VINORELBINE 4.0 1 8.63
CHEMBL9470 SHIKONIN — 1 8.54
CHEMBL1972860 ELESCLOMOL 3.0 1 8.29
CHEMBL159 VINBLASTINE 4.0 1 8.25
CHEMBL53463 DOXORUBICIN 4.0 1 7.76
CHEMBL1879463 DACTOLISIB 3.0 1 7.73
CHEMBL65 CAMPTOTHECIN -1.0 1 7.47
CHEMBL2107358 OBATOCLAX MESYLATE 3.0 1 7.40
CHEMBL105 MITOMYCIN 4.0 1 7.14
CHEMBL603469 LESTAURTINIB 3.0 1 6.89
CHEMBL608533 MIDOSTAURIN 4.0 1 6.88
CHEMBL1201182 TEMSIROLIMUS 4.0 1 6.72
CHEMBL575448 BMS-754807 2.0 1 6.67
CHEMBL585951 — — 1 6.63
CHEMBL6067492 BLEOMYCIN 4.0 1 6.53
CHEMBL109480 TANESPIMYCIN 3.0 1 6.53
CHEMBL1171837 PONATINIB 4.0 1 6.44
CHEMBL217354 — — 1 6.41
CHEMBL44657 ETOPOSIDE 4.0 1 6.29
CHEMBL2165191 AZD-6482 2.0 2 6.28
CHEMBL1801204 AZD-8055 1.0 1 6.20
CHEMBL2041933 AZD-7762 1.0 1 6.19
CHEMBL289228 TIPIFARNIB 3.0 1 6.14
CHEMBL507361 MIRDAMETINIB 2.0 1 6.13
CHEMBL449158 BRYOSTATIN 1 2.0 1 6.03

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL94657 PATUPILONE IC50 = 0.02135 nM 10.67
CHEMBL888 GEMCITABINE IC50 = 0.07513 nM 10.12
CHEMBL96926 THAPSIGARGIN IC50 = 0.1495 nM 9.82
CHEMBL3545252 DOCETAXEL IC50 = 0.466 nM 9.33
CHEMBL252164 LUMINESPIB IC50 = 1.862 nM 8.73
CHEMBL553025 VINORELBINE IC50 = 2.334 nM 8.63
CHEMBL9470 SHIKONIN IC50 = 2.91 nM 8.54
CHEMBL1972860 ELESCLOMOL IC50 = 5.164 nM 8.29
CHEMBL159 VINBLASTINE IC50 = 5.607 nM 8.25
CHEMBL53463 DOXORUBICIN IC50 = 17.4 nM 7.76
CHEMBL1879463 DACTOLISIB IC50 = 18.72 nM 7.73
CHEMBL65 CAMPTOTHECIN IC50 = 33.57 nM 7.47
CHEMBL2107358 OBATOCLAX MESYLATE IC50 = 40.18 nM 7.40
CHEMBL105 MITOMYCIN IC50 = 72.58 nM 7.14
CHEMBL603469 LESTAURTINIB IC50 = 127.82 nM 6.89
CHEMBL608533 MIDOSTAURIN IC50 = 133.16 nM 6.88
CHEMBL1201182 TEMSIROLIMUS IC50 = 189.22 nM 6.72
CHEMBL575448 BMS-754807 IC50 = 216.0 nM 6.67
CHEMBL585951 — IC50 = 232.2 nM 6.63
CHEMBL109480 TANESPIMYCIN IC50 = 294.94 nM 6.53
CHEMBL6067492 BLEOMYCIN IC50 = 295.33 nM 6.53
CHEMBL1171837 PONATINIB IC50 = 364.55 nM 6.44
CHEMBL217354 — IC50 = 388.26 nM 6.41
CHEMBL44657 ETOPOSIDE IC50 = 518.38 nM 6.29
CHEMBL2165191 AZD-6482 IC50 = 529.2 nM 6.28
CHEMBL1801204 AZD-8055 IC50 = 631.67 nM 6.20
CHEMBL2041933 AZD-7762 IC50 = 640.23 nM 6.19
CHEMBL289228 TIPIFARNIB IC50 = 725.5 nM 6.14
CHEMBL507361 MIRDAMETINIB IC50 = 734.16 nM 6.13
CHEMBL449158 BRYOSTATIN 1 IC50 = 932.11 nM 6.03
CHEMBL521851 PICTILISIB IC50 = 1042.33 nM 5.98
CHEMBL472940 — IC50 = 1178.33 nM 5.93
CHEMBL258844 — IC50 = 1388.92 nM 5.86
CHEMBL259181 — IC50 = 1430.82 nM 5.84
CHEMBL191384 — IC50 = 1586.85 nM 5.80
CHEMBL393929 — IC50 = 1614.08 nM 5.79
CHEMBL1084546 PF-00562271 IC50 = 1626.28 nM 5.79
CHEMBL1190711 — IC50 = 1657.55 nM 5.78
CHEMBL135561 — IC50 = 1676.46 nM 5.78
CHEMBL803 CYTARABINE IC50 = 1729.15 nM 5.76
CHEMBL3349342 — IC50 = 2015.76 nM 5.70
CHEMBL2165191 AZD-6482 IC50 = 1990.33 nM 5.70
CHEMBL189963 PALBOCICLIB IC50 = 2069.45 nM 5.68
CHEMBL573107 — IC50 = 2306.61 nM 5.64
CHEMBL577784 BX-795 IC50 = 2291.42 nM 5.64
CHEMBL2363137 — IC50 = 2333.79 nM 5.63
CHEMBL558642 GSK-650394 IC50 = 2700.82 nM 5.57
CHEMBL1079175 MK-2206 IC50 = 3466.78 nM 5.46
CHEMBL379975 — IC50 = 4094.69 nM 5.39
CHEMBL202721 — IC50 = 4404.17 nM 5.36