Assay Detail
Functional
CHEMBL2363706
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SANGER: Inhibition of human TCCSUP cell growth in a cell viability assay.
99
Total Activities
98
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | TCC-SUP |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 99 | 5.49 | 8.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 8.35 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 7.99 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 7.87 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 7.63 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 7.57 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 7.41 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 7.29 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 7.22 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 7.19 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 7.08 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 7.06 |
| CHEMBL608533 | MIDOSTAURIN | 4.0 | 1 | 6.78 |
| CHEMBL217354 | — | — | 1 | 6.44 |
| CHEMBL575448 | BMS-754807 | 2.0 | 1 | 6.37 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 6.32 |
| CHEMBL9470 | SHIKONIN | — | 1 | 6.26 |
| CHEMBL1171837 | PONATINIB | 4.0 | 1 | 5.99 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 5.93 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 5.91 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 5.90 |
| CHEMBL1801204 | AZD-8055 | 1.0 | 1 | 5.83 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.76 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 5.73 |
| CHEMBL135561 | — | — | 1 | 5.53 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 5.52 |
| CHEMBL803 | CYTARABINE | 4.0 | 1 | 5.48 |
| CHEMBL939 | GEFITINIB | 4.0 | 1 | 5.39 |
| CHEMBL521851 | PICTILISIB | 2.0 | 1 | 5.37 |
| CHEMBL2363137 | — | — | 1 | 5.32 |
| CHEMBL573107 | — | — | 1 | 5.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL94657 | PATUPILONE | IC50 | = | 4.497 | nM | 8.35 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 10.36 | nM | 7.99 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 13.46 | nM | 7.87 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 23.63 | nM | 7.63 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 27.06 | nM | 7.57 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 39.04 | nM | 7.41 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 51.64 | nM | 7.29 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 59.64 | nM | 7.22 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 64.53 | nM | 7.19 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 82.33 | nM | 7.08 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 86.85 | nM | 7.06 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 164.69 | nM | 6.78 |
| CHEMBL217354 | — | IC50 | = | 360.7 | nM | 6.44 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 430.88 | nM | 6.37 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 481.7 | nM | 6.32 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 554.45 | nM | 6.26 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 1017.32 | nM | 5.99 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 1167.85 | nM | 5.93 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 1230.83 | nM | 5.91 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 1250.29 | nM | 5.90 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 1469.6 | nM | 5.83 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 1728.29 | nM | 5.76 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 1850.66 | nM | 5.73 |
| CHEMBL135561 | — | IC50 | = | 2961.06 | nM | 5.53 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 3026.36 | nM | 5.52 |
| CHEMBL803 | CYTARABINE | IC50 | = | 3304.46 | nM | 5.48 |
| CHEMBL939 | GEFITINIB | IC50 | = | 4110.5 | nM | 5.39 |
| CHEMBL521851 | PICTILISIB | IC50 | = | 4247.88 | nM | 5.37 |
| CHEMBL2363137 | — | IC50 | = | 4810.69 | nM | 5.32 |
| CHEMBL573107 | — | IC50 | = | 5717.78 | nM | 5.24 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 5801.86 | nM | 5.24 |
| CHEMBL1091644 | LINSITINIB | IC50 | = | 5932.59 | nM | 5.23 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 6603.49 | nM | 5.18 |
| CHEMBL2165191 | AZD-6482 | IC50 | = | 7095.88 | nM | 5.15 |
| CHEMBL2137530 | SERDEMETAN | IC50 | = | 7945.25 | nM | 5.10 |
| CHEMBL577784 | BX-795 | IC50 | = | 8300.43 | nM | 5.08 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 8569.61 | nM | 5.07 |
| CHEMBL11359 | CISPLATIN | IC50 | = | 8498.84 | nM | 5.07 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 9484.8 | nM | 5.02 |
| CHEMBL3349342 | — | IC50 | = | 9973.4 | nM | 5.00 |
| CHEMBL585951 | — | IC50 | = | 10006.6 | nM | 5.00 |
| CHEMBL258844 | — | IC50 | = | 10512.98 | nM | 4.98 |
| CHEMBL221137 | EMBELIN | IC50 | = | 11551.02 | nM | 4.94 |
| CHEMBL399530 | — | IC50 | = | 11842.34 | nM | 4.93 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 11618.71 | nM | 4.93 |
| CHEMBL105442 | CI-1040 | IC50 | = | 12575.73 | nM | 4.90 |
| CHEMBL189963 | PALBOCICLIB | IC50 | = | 13128.4 | nM | 4.88 |
| CHEMBL379975 | — | IC50 | = | 14829.0 | nM | 4.83 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 15941.87 | nM | 4.80 |
| CHEMBL202721 | — | IC50 | = | 17206.75 | nM | 4.76 |