Assay Detail
Functional
CHEMBL2363710
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SANGER: Inhibition of human 5637 cell growth in a cell viability assay.
99
Total Activities
98
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | 5637 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 99 | 5.87 | 9.84 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 9.84 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 9.20 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 9.02 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 8.38 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 8.12 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 7.94 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 7.55 |
| CHEMBL6067492 | BLEOMYCIN | 4.0 | 1 | 7.54 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.50 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 7.50 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 7.45 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 7.24 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 7.10 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 7.09 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 7.08 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 6.71 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 6.64 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 6.53 |
| CHEMBL803 | CYTARABINE | 4.0 | 1 | 6.30 |
| CHEMBL217354 | — | — | 1 | 6.26 |
| CHEMBL575448 | BMS-754807 | 2.0 | 1 | 6.22 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 6.20 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 6.06 |
| CHEMBL289228 | TIPIFARNIB | 3.0 | 1 | 5.99 |
| CHEMBL1173655 | AFATINIB | 4.0 | 1 | 5.99 |
| CHEMBL288441 | BOSUTINIB | 4.0 | 1 | 5.94 |
| CHEMBL608533 | MIDOSTAURIN | 4.0 | 1 | 5.75 |
| CHEMBL1801204 | AZD-8055 | 1.0 | 1 | 5.75 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 5.68 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.63 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 0.1433 | nM | 9.84 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 0.6382 | nM | 9.20 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 0.951 | nM | 9.02 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 4.183 | nM | 8.38 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 7.552 | nM | 8.12 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 11.42 | nM | 7.94 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 28.22 | nM | 7.55 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 28.97 | nM | 7.54 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 31.87 | nM | 7.50 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 31.93 | nM | 7.50 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 35.46 | nM | 7.45 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 57.4 | nM | 7.24 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 79.23 | nM | 7.10 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 82.07 | nM | 7.09 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 83.67 | nM | 7.08 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 192.78 | nM | 6.71 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 230.62 | nM | 6.64 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 293.34 | nM | 6.53 |
| CHEMBL803 | CYTARABINE | IC50 | = | 501.48 | nM | 6.30 |
| CHEMBL217354 | — | IC50 | = | 551.67 | nM | 6.26 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 600.92 | nM | 6.22 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 624.66 | nM | 6.20 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 866.93 | nM | 6.06 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 1029.22 | nM | 5.99 |
| CHEMBL1173655 | AFATINIB | IC50 | = | 1015.1 | nM | 5.99 |
| CHEMBL288441 | BOSUTINIB | IC50 | = | 1138.03 | nM | 5.94 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 1772.68 | nM | 5.75 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 1774.22 | nM | 5.75 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 2102.98 | nM | 5.68 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 2321.29 | nM | 5.63 |
| CHEMBL521851 | PICTILISIB | IC50 | = | 2710.35 | nM | 5.57 |
| CHEMBL1084546 | PF-00562271 | IC50 | = | 2924.39 | nM | 5.53 |
| CHEMBL393929 | — | IC50 | = | 3085.32 | nM | 5.51 |
| CHEMBL379975 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL558642 | GSK-650394 | IC50 | = | 3206.69 | nM | 5.49 |
| CHEMBL443684 | NAVITOCLAX | IC50 | = | 3611.03 | nM | 5.44 |
| CHEMBL259181 | — | IC50 | = | 4178.28 | nM | 5.38 |
| CHEMBL11359 | CISPLATIN | IC50 | = | 4518.48 | nM | 5.34 |
| CHEMBL573107 | — | IC50 | = | 4614.44 | nM | 5.34 |
| CHEMBL2137530 | SERDEMETAN | IC50 | = | 4796.52 | nM | 5.32 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 4904.87 | nM | 5.31 |
| CHEMBL585951 | — | IC50 | = | 5038.98 | nM | 5.30 |
| CHEMBL2363137 | — | IC50 | = | 7253.07 | nM | 5.14 |
| CHEMBL399530 | — | IC50 | = | 7338.83 | nM | 5.13 |
| CHEMBL521686 | OLAPARIB | IC50 | = | 7928.6 | nM | 5.10 |
| CHEMBL577784 | BX-795 | IC50 | = | 8079.04 | nM | 5.09 |
| CHEMBL939 | GEFITINIB | IC50 | = | 8310.55 | nM | 5.08 |
| CHEMBL3349342 | — | IC50 | = | 8271.23 | nM | 5.08 |
| CHEMBL202721 | — | IC50 | = | 9448.32 | nM | 5.03 |
| CHEMBL1079175 | MK-2206 | IC50 | = | 9849.84 | nM | 5.01 |