Assay Detail
Functional
CHEMBL2363711
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SANGER: Inhibition of human 639-V cell growth in a cell viability assay.
99
Total Activities
98
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | 639-V |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 99 | 5.75 | 9.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 9.77 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 9.66 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 9.29 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 9.19 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 8.76 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 8.31 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 8.25 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 8.18 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.80 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 7.78 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 7.11 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 7.07 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 6.82 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 6.81 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 6.71 |
| CHEMBL585951 | — | — | 1 | 6.66 |
| CHEMBL6067492 | BLEOMYCIN | 4.0 | 1 | 6.66 |
| CHEMBL9470 | SHIKONIN | — | 1 | 6.58 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 6.47 |
| CHEMBL217354 | — | — | 1 | 6.28 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 6.16 |
| CHEMBL507361 | MIRDAMETINIB | 2.0 | 1 | 6.14 |
| CHEMBL608533 | MIDOSTAURIN | 4.0 | 1 | 6.04 |
| CHEMBL575448 | BMS-754807 | 2.0 | 1 | 6.00 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 6.00 |
| CHEMBL259181 | — | — | 1 | 5.94 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 5.93 |
| CHEMBL289228 | TIPIFARNIB | 3.0 | 1 | 5.92 |
| CHEMBL1190711 | — | — | 1 | 5.84 |
| CHEMBL188678 | — | — | 1 | 5.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 0.1714 | nM | 9.77 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 0.218 | nM | 9.66 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 0.5118 | nM | 9.29 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 0.6471 | nM | 9.19 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 1.759 | nM | 8.76 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 4.852 | nM | 8.31 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 5.605 | nM | 8.25 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 6.609 | nM | 8.18 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 15.91 | nM | 7.80 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 16.74 | nM | 7.78 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 78.52 | nM | 7.11 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 85.42 | nM | 7.07 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 150.13 | nM | 6.82 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 155.96 | nM | 6.81 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 193.14 | nM | 6.71 |
| CHEMBL585951 | — | IC50 | = | 219.66 | nM | 6.66 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 219.56 | nM | 6.66 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 265.01 | nM | 6.58 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 340.85 | nM | 6.47 |
| CHEMBL217354 | — | IC50 | = | 521.38 | nM | 6.28 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 689.1 | nM | 6.16 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 727.35 | nM | 6.14 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 920.63 | nM | 6.04 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 990.07 | nM | 6.00 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 1007.97 | nM | 6.00 |
| CHEMBL259181 | — | IC50 | = | 1149.77 | nM | 5.94 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 1166.7 | nM | 5.93 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 1193.44 | nM | 5.92 |
| CHEMBL1190711 | — | IC50 | = | 1427.77 | nM | 5.84 |
| CHEMBL188678 | — | IC50 | = | 1441.28 | nM | 5.84 |
| CHEMBL521851 | PICTILISIB | IC50 | = | 1502.45 | nM | 5.82 |
| CHEMBL2363137 | — | IC50 | = | 1610.13 | nM | 5.79 |
| CHEMBL2165191 | AZD-6482 | IC50 | = | 1631.44 | nM | 5.79 |
| CHEMBL393929 | — | IC50 | = | 2275.37 | nM | 5.64 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 2427.58 | nM | 5.62 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 2453.82 | nM | 5.61 |
| CHEMBL573107 | — | IC50 | = | 2717.03 | nM | 5.57 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 3460.57 | nM | 5.46 |
| CHEMBL939 | GEFITINIB | IC50 | = | 3577.92 | nM | 5.45 |
| CHEMBL202721 | — | IC50 | = | 4551.71 | nM | 5.34 |
| CHEMBL191384 | — | IC50 | = | 4835.62 | nM | 5.32 |
| CHEMBL2165191 | AZD-6482 | IC50 | = | 4782.51 | nM | 5.32 |
| CHEMBL558642 | GSK-650394 | IC50 | = | 5170.58 | nM | 5.29 |
| CHEMBL379975 | — | IC50 | = | 5403.48 | nM | 5.27 |
| CHEMBL11359 | CISPLATIN | IC50 | = | 5888.71 | nM | 5.23 |
| CHEMBL1614701 | SELUMETINIB | IC50 | = | 6129.33 | nM | 5.21 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 6323.79 | nM | 5.20 |
| CHEMBL1084546 | PF-00562271 | IC50 | = | 6751.27 | nM | 5.17 |
| CHEMBL577784 | BX-795 | IC50 | = | 7464.0 | nM | 5.13 |
| CHEMBL3349342 | — | IC50 | = | 9559.25 | nM | 5.02 |