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Assay Detail

CHEMBL2363713

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Functional
SANGER: Inhibition of human 697 cell growth in a cell viability assay.
ChEMBL ↗
130
Total Activities
129
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type 697
Confidence 1 — Organism
Curated By Autocuration

Target

697 (CHEMBL2366253) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute

· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 130 6.21 9.89

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL105 MITOMYCIN 4.0 1 9.89
CHEMBL96926 THAPSIGARGIN — 1 9.37
CHEMBL428647 PACLITAXEL 4.0 1 8.82
CHEMBL3545252 DOCETAXEL 4.0 1 8.77
CHEMBL1201182 TEMSIROLIMUS 4.0 1 8.77
CHEMBL94657 PATUPILONE 3.0 1 8.75
CHEMBL325041 BORTEZOMIB 3.0 1 8.70
CHEMBL65 CAMPTOTHECIN -1.0 1 8.69
CHEMBL553025 VINORELBINE 4.0 1 8.37
CHEMBL159 VINBLASTINE 4.0 1 8.21
CHEMBL1972860 ELESCLOMOL 3.0 1 8.21
CHEMBL413 SIROLIMUS 4.0 1 8.20
CHEMBL1256459 TORIN1 — 1 8.20
CHEMBL888 GEMCITABINE 4.0 1 8.20
CHEMBL514499 GW843682X — 1 8.01
CHEMBL803 CYTARABINE 4.0 1 7.97
CHEMBL34259 METHOTREXATE 4.0 1 7.90
CHEMBL513909 BI-2536 2.0 1 7.78
CHEMBL1879463 DACTOLISIB 3.0 1 7.76
CHEMBL53463 DOXORUBICIN 4.0 1 7.72
CHEMBL300389 — — 1 7.71
CHEMBL252164 LUMINESPIB 2.0 1 7.69
CHEMBL572878 TOZASERTIB 2.0 1 7.61
CHEMBL603469 LESTAURTINIB 3.0 1 7.58
CHEMBL449158 BRYOSTATIN 1 2.0 1 7.54
CHEMBL379300 A-443654 — 1 7.48
CHEMBL2107358 OBATOCLAX MESYLATE 3.0 1 7.27
CHEMBL27759 ENTINOSTAT 3.0 1 7.00
CHEMBL443684 NAVITOCLAX 3.0 1 6.96
CHEMBL2041933 AZD-7762 1.0 1 6.96

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL105 MITOMYCIN IC50 = 0.1283 nM 9.89
CHEMBL96926 THAPSIGARGIN IC50 = 0.4253 nM 9.37
CHEMBL428647 PACLITAXEL IC50 = 1.495 nM 8.82
CHEMBL1201182 TEMSIROLIMUS IC50 = 1.7 nM 8.77
CHEMBL3545252 DOCETAXEL IC50 = 1.718 nM 8.77
CHEMBL94657 PATUPILONE IC50 = 1.781 nM 8.75
CHEMBL325041 BORTEZOMIB IC50 = 1.988 nM 8.70
CHEMBL65 CAMPTOTHECIN IC50 = 2.029 nM 8.69
CHEMBL553025 VINORELBINE IC50 = 4.228 nM 8.37
CHEMBL1972860 ELESCLOMOL IC50 = 6.126 nM 8.21
CHEMBL159 VINBLASTINE IC50 = 6.225 nM 8.21
CHEMBL413 SIROLIMUS IC50 = 6.279 nM 8.20
CHEMBL888 GEMCITABINE IC50 = 6.247 nM 8.20
CHEMBL1256459 TORIN1 IC50 = 6.337 nM 8.20
CHEMBL514499 GW843682X IC50 = 9.865 nM 8.01
CHEMBL803 CYTARABINE IC50 = 10.6 nM 7.97
CHEMBL34259 METHOTREXATE IC50 = 12.57 nM 7.90
CHEMBL513909 BI-2536 IC50 = 16.68 nM 7.78
CHEMBL1879463 DACTOLISIB IC50 = 17.43 nM 7.76
CHEMBL53463 DOXORUBICIN IC50 = 19.09 nM 7.72
CHEMBL300389 — IC50 = 19.71 nM 7.71
CHEMBL252164 LUMINESPIB IC50 = 20.31 nM 7.69
CHEMBL572878 TOZASERTIB IC50 = 24.71 nM 7.61
CHEMBL603469 LESTAURTINIB IC50 = 26.52 nM 7.58
CHEMBL449158 BRYOSTATIN 1 IC50 = 28.53 nM 7.54
CHEMBL379300 A-443654 IC50 = 32.81 nM 7.48
CHEMBL2107358 OBATOCLAX MESYLATE IC50 = 53.23 nM 7.27
CHEMBL27759 ENTINOSTAT IC50 = 99.76 nM 7.00
CHEMBL443684 NAVITOCLAX IC50 = 108.39 nM 6.96
CHEMBL2041933 AZD-7762 IC50 = 110.63 nM 6.96
CHEMBL189963 PALBOCICLIB IC50 = 148.38 nM 6.83
CHEMBL1171837 PONATINIB IC50 = 188.71 nM 6.72
CHEMBL5416410 DASATINIB IC50 = 199.87 nM 6.70
CHEMBL44657 ETOPOSIDE IC50 = 243.2 nM 6.61
CHEMBL1801204 AZD-8055 IC50 = 273.67 nM 6.56
CHEMBL515416 — IC50 = 292.8 nM 6.53
CHEMBL220241 GSK-269962A IC50 = 299.1 nM 6.52
CHEMBL392695 S-TRITYL-L-CYSTEINE IC50 = 327.97 nM 6.48
CHEMBL2144069 — IC50 = 363.88 nM 6.44
CHEMBL585951 — IC50 = 372.59 nM 6.43
CHEMBL379975 — IC50 = 431.16 nM 6.37
CHEMBL509032 TAE-684 IC50 = 432.15 nM 6.36
CHEMBL288441 BOSUTINIB IC50 = 456.33 nM 6.34
CHEMBL98 VORINOSTAT IC50 = 473.41 nM 6.33
CHEMBL4298697 — IC50 = 464.58 nM 6.33
CHEMBL1190711 — IC50 = 581.88 nM 6.24
CHEMBL535 SUNITINIB IC50 = 614.25 nM 6.21
CHEMBL1673039 — IC50 = 653.75 nM 6.18
CHEMBL608533 MIDOSTAURIN IC50 = 671.32 nM 6.17
CHEMBL202721 — IC50 = 739.09 nM 6.13