Assay Detail
Functional
CHEMBL2363715
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SANGER: Inhibition of human 786-0 cell growth in a cell viability assay.
99
Total Activities
98
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | 786-0 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 99 | 6.00 | 10.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 10.64 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 10.61 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 9.96 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 9.11 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 8.52 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 8.30 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 8.18 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 8.11 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 8.07 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 7.89 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 7.85 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 7.81 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 7.65 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 7.58 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 7.29 |
| CHEMBL6067492 | BLEOMYCIN | 4.0 | 1 | 7.09 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 6.81 |
| CHEMBL585951 | — | — | 1 | 6.64 |
| CHEMBL1171837 | PONATINIB | 4.0 | 1 | 6.58 |
| CHEMBL1090771 | AVAGACESTAT | 2.0 | 1 | 6.49 |
| CHEMBL289228 | TIPIFARNIB | 3.0 | 1 | 6.47 |
| CHEMBL9470 | SHIKONIN | — | 1 | 6.46 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 6.41 |
| CHEMBL507361 | MIRDAMETINIB | 2.0 | 1 | 6.38 |
| CHEMBL608533 | MIDOSTAURIN | 4.0 | 1 | 6.33 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 6.31 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 6.19 |
| CHEMBL803 | CYTARABINE | 4.0 | 1 | 6.17 |
| CHEMBL591429 | PAC-1 | 1.0 | 1 | 6.13 |
| CHEMBL575448 | BMS-754807 | 2.0 | 1 | 6.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL888 | GEMCITABINE | IC50 | = | 0.023 | nM | 10.64 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 0.02478 | nM | 10.61 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 0.1104 | nM | 9.96 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 0.776 | nM | 9.11 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 2.992 | nM | 8.52 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 5.021 | nM | 8.30 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 6.627 | nM | 8.18 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 7.856 | nM | 8.11 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 8.472 | nM | 8.07 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 12.87 | nM | 7.89 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 14.01 | nM | 7.85 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 15.58 | nM | 7.81 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 22.29 | nM | 7.65 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 26.18 | nM | 7.58 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 51.69 | nM | 7.29 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 80.84 | nM | 7.09 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 153.81 | nM | 6.81 |
| CHEMBL585951 | — | IC50 | = | 227.63 | nM | 6.64 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 262.28 | nM | 6.58 |
| CHEMBL1090771 | AVAGACESTAT | IC50 | = | 321.73 | nM | 6.49 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 341.56 | nM | 6.47 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 343.75 | nM | 6.46 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 388.23 | nM | 6.41 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 417.4 | nM | 6.38 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 473.44 | nM | 6.33 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 492.2 | nM | 6.31 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 643.3 | nM | 6.19 |
| CHEMBL803 | CYTARABINE | IC50 | = | 668.71 | nM | 6.17 |
| CHEMBL591429 | PAC-1 | IC50 | = | 738.6 | nM | 6.13 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 969.04 | nM | 6.01 |
| CHEMBL258844 | — | IC50 | = | 1104.83 | nM | 5.96 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 1089.34 | nM | 5.96 |
| CHEMBL259181 | — | IC50 | = | 1260.09 | nM | 5.90 |
| CHEMBL2165191 | AZD-6482 | IC50 | = | 1312.83 | nM | 5.88 |
| CHEMBL1190711 | — | IC50 | = | 1360.48 | nM | 5.87 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 1557.22 | nM | 5.81 |
| CHEMBL2137530 | SERDEMETAN | IC50 | = | 1729.89 | nM | 5.76 |
| CHEMBL2165191 | AZD-6482 | IC50 | = | 1985.63 | nM | 5.70 |
| CHEMBL189963 | PALBOCICLIB | IC50 | = | 2154.39 | nM | 5.67 |
| CHEMBL939 | GEFITINIB | IC50 | = | 2184.06 | nM | 5.66 |
| CHEMBL3349342 | — | IC50 | = | 2369.21 | nM | 5.62 |
| CHEMBL521851 | PICTILISIB | IC50 | = | 2592.38 | nM | 5.59 |
| CHEMBL558642 | GSK-650394 | IC50 | = | 2948.25 | nM | 5.53 |
| CHEMBL191384 | — | IC50 | = | 3079.05 | nM | 5.51 |
| CHEMBL1084546 | PF-00562271 | IC50 | = | 3057.84 | nM | 5.51 |
| CHEMBL1173655 | AFATINIB | IC50 | = | 3064.08 | nM | 5.51 |
| CHEMBL105442 | CI-1040 | IC50 | = | 3272.43 | nM | 5.49 |
| CHEMBL472940 | — | IC50 | = | 3318.05 | nM | 5.48 |
| CHEMBL2363137 | — | IC50 | = | 3918.31 | nM | 5.41 |
| CHEMBL11359 | CISPLATIN | IC50 | = | 4465.08 | nM | 5.35 |