Assay Detail
Functional
CHEMBL2363719
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SANGER: Inhibition of human A101D cell growth in a cell viability assay.
139
Total Activities
137
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A101D |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 139 | 5.88 | 9.65 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 9.65 |
| CHEMBL9470 | SHIKONIN | — | 1 | 9.15 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 9.07 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 8.32 |
| CHEMBL2144069 | — | — | 1 | 8.23 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 8.06 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 8.03 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.02 |
| CHEMBL514499 | GW843682X | — | 1 | 7.95 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 7.94 |
| CHEMBL507361 | MIRDAMETINIB | 2.0 | 1 | 7.94 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 7.81 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 7.70 |
| CHEMBL300389 | — | — | 1 | 7.69 |
| CHEMBL1256459 | TORIN1 | — | 1 | 7.58 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 7.51 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 7.50 |
| CHEMBL413 | SIROLIMUS | 4.0 | 1 | 7.49 |
| CHEMBL64925 | MG-132 | — | 2 | 7.48 |
| CHEMBL513909 | BI-2536 | 2.0 | 1 | 7.43 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 7.41 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 7.31 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.29 |
| CHEMBL3349342 | — | — | 1 | 7.29 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 7.17 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 7.08 |
| CHEMBL217354 | — | — | 1 | 7.06 |
| CHEMBL379300 | A-443654 | — | 1 | 6.88 |
| CHEMBL105442 | CI-1040 | 2.0 | 1 | 6.67 |
| CHEMBL1614701 | SELUMETINIB | 4.0 | 1 | 6.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 0.2254 | nM | 9.65 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 0.7121 | nM | 9.15 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 0.856 | nM | 9.07 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 4.818 | nM | 8.32 |
| CHEMBL2144069 | — | IC50 | = | 5.819 | nM | 8.23 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 8.674 | nM | 8.06 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 9.373 | nM | 8.03 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 9.598 | nM | 8.02 |
| CHEMBL514499 | GW843682X | IC50 | = | 11.3 | nM | 7.95 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 11.45 | nM | 7.94 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 11.42 | nM | 7.94 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 15.49 | nM | 7.81 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 19.87 | nM | 7.70 |
| CHEMBL300389 | — | IC50 | = | 20.54 | nM | 7.69 |
| CHEMBL1256459 | TORIN1 | IC50 | = | 26.5 | nM | 7.58 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 30.55 | nM | 7.51 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 31.39 | nM | 7.50 |
| CHEMBL413 | SIROLIMUS | IC50 | = | 32.62 | nM | 7.49 |
| CHEMBL64925 | MG-132 | IC50 | = | 32.79 | nM | 7.48 |
| CHEMBL513909 | BI-2536 | IC50 | = | 37.48 | nM | 7.43 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 38.97 | nM | 7.41 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 48.73 | nM | 7.31 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 51.48 | nM | 7.29 |
| CHEMBL3349342 | — | IC50 | = | 51.17 | nM | 7.29 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 82.31 | nM | 7.08 |
| CHEMBL217354 | — | IC50 | = | 87.5 | nM | 7.06 |
| CHEMBL379300 | A-443654 | IC50 | = | 132.65 | nM | 6.88 |
| CHEMBL105442 | CI-1040 | IC50 | = | 214.0 | nM | 6.67 |
| CHEMBL1614701 | SELUMETINIB | IC50 | = | 240.33 | nM | 6.62 |
| CHEMBL585951 | — | IC50 | = | 245.31 | nM | 6.61 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 257.84 | nM | 6.59 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 257.45 | nM | 6.59 |
| CHEMBL64925 | MG-132 | IC50 | = | 300.94 | nM | 6.52 |
| CHEMBL1230020 | PLX-4720 | IC50 | = | 325.89 | nM | 6.49 |
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 403.0 | nM | 6.39 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 480.53 | nM | 6.32 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 489.68 | nM | 6.31 |
| CHEMBL477989 | SB590885 | IC50 | = | 499.96 | nM | 6.30 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 587.89 | nM | 6.23 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 619.72 | nM | 6.21 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 976.46 | nM | 6.01 |
| CHEMBL521851 | PICTILISIB | IC50 | = | 990.19 | nM | 6.00 |
| CHEMBL5416410 | DASATINIB | IC50 | = | 1030.43 | nM | 5.99 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 1198.12 | nM | 5.92 |
| CHEMBL509032 | TAE-684 | IC50 | = | 1571.13 | nM | 5.80 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 1667.81 | nM | 5.78 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 1699.83 | nM | 5.77 |
| CHEMBL392695 | S-TRITYL-L-CYSTEINE | IC50 | = | 1725.32 | nM | 5.76 |
| CHEMBL220241 | GSK-269962A | IC50 | = | 1870.34 | nM | 5.73 |