Assay Detail
Functional
CHEMBL2363723
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SANGER: Inhibition of human A253 cell growth in a cell viability assay.
112
Total Activities
110
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A253 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 112 | 5.54 | 9.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 9.68 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 8.91 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 8.76 |
| CHEMBL9470 | SHIKONIN | — | 1 | 8.12 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 7.99 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 7.80 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 7.76 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 7.73 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.34 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 7.30 |
| CHEMBL514499 | GW843682X | — | 1 | 7.27 |
| CHEMBL300389 | — | — | 1 | 7.19 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 7.08 |
| CHEMBL513909 | BI-2536 | 2.0 | 1 | 7.05 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 6.99 |
| CHEMBL64925 | MG-132 | — | 2 | 6.79 |
| CHEMBL585951 | — | — | 1 | 6.58 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 6.46 |
| CHEMBL379300 | A-443654 | — | 1 | 6.41 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 6.24 |
| CHEMBL217354 | — | — | 1 | 6.24 |
| CHEMBL1256459 | TORIN1 | — | 1 | 6.00 |
| CHEMBL507361 | MIRDAMETINIB | 2.0 | 1 | 5.90 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 5.74 |
| CHEMBL554 | LAPATINIB | 4.0 | 1 | 5.71 |
| CHEMBL512504 | — | — | 1 | 5.65 |
| CHEMBL553 | ERLOTINIB | 4.0 | 1 | 5.56 |
| CHEMBL6067492 | BLEOMYCIN | 4.0 | 1 | 5.54 |
| CHEMBL3349342 | — | — | 1 | 5.48 |
| CHEMBL392695 | S-TRITYL-L-CYSTEINE | — | 1 | 5.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 0.2085 | nM | 9.68 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 1.223 | nM | 8.91 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 1.728 | nM | 8.76 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 7.493 | nM | 8.12 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 10.31 | nM | 7.99 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 15.73 | nM | 7.80 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 17.38 | nM | 7.76 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 18.43 | nM | 7.73 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 46.12 | nM | 7.34 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 50.52 | nM | 7.30 |
| CHEMBL514499 | GW843682X | IC50 | = | 53.19 | nM | 7.27 |
| CHEMBL300389 | — | IC50 | = | 64.91 | nM | 7.19 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 82.65 | nM | 7.08 |
| CHEMBL513909 | BI-2536 | IC50 | = | 88.22 | nM | 7.05 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 102.28 | nM | 6.99 |
| CHEMBL64925 | MG-132 | IC50 | = | 161.28 | nM | 6.79 |
| CHEMBL585951 | — | IC50 | = | 261.12 | nM | 6.58 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 345.64 | nM | 6.46 |
| CHEMBL379300 | A-443654 | IC50 | = | 392.62 | nM | 6.41 |
| CHEMBL217354 | — | IC50 | = | 570.19 | nM | 6.24 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 575.25 | nM | 6.24 |
| CHEMBL1256459 | TORIN1 | IC50 | = | 988.85 | nM | 6.00 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 1259.7 | nM | 5.90 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 1822.39 | nM | 5.74 |
| CHEMBL554 | LAPATINIB | IC50 | = | 1973.35 | nM | 5.71 |
| CHEMBL512504 | — | IC50 | = | 2253.77 | nM | 5.65 |
| CHEMBL553 | ERLOTINIB | IC50 | = | 2751.6 | nM | 5.56 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 2855.22 | nM | 5.54 |
| CHEMBL3349342 | — | IC50 | = | 3321.65 | nM | 5.48 |
| CHEMBL392695 | S-TRITYL-L-CYSTEINE | IC50 | = | 3711.77 | nM | 5.43 |
| CHEMBL5416410 | DASATINIB | IC50 | = | 3732.46 | nM | 5.43 |
| CHEMBL64925 | MG-132 | IC50 | = | 3763.02 | nM | 5.42 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 3914.36 | nM | 5.41 |
| CHEMBL413 | SIROLIMUS | IC50 | = | 4021.01 | nM | 5.40 |
| CHEMBL577784 | BX-795 | IC50 | = | 4188.93 | nM | 5.38 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 4903.07 | nM | 5.31 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 4977.08 | nM | 5.30 |
| CHEMBL2363137 | — | IC50 | = | 5927.04 | nM | 5.23 |
| CHEMBL379975 | — | IC50 | = | 6709.0 | nM | 5.17 |
| CHEMBL202721 | — | IC50 | = | 6773.05 | nM | 5.17 |
| CHEMBL221137 | EMBELIN | IC50 | = | 7746.86 | nM | 5.11 |
| CHEMBL191384 | — | IC50 | = | 8139.59 | nM | 5.09 |
| CHEMBL477989 | SB590885 | IC50 | = | 8536.12 | nM | 5.07 |
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 8846.61 | nM | 5.05 |
| CHEMBL515416 | — | IC50 | = | 9054.6 | nM | 5.04 |
| CHEMBL1643959 | — | IC50 | = | 10319.62 | nM | 4.99 |
| CHEMBL258844 | — | IC50 | = | 10389.59 | nM | 4.98 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 10463.64 | nM | 4.98 |
| CHEMBL1614701 | SELUMETINIB | IC50 | = | 10790.19 | nM | 4.97 |
| CHEMBL477772 | PAZOPANIB | IC50 | = | 11391.07 | nM | 4.94 |