Assay Detail
Functional
CHEMBL2363726
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SANGER: Inhibition of human A375 cell growth in a cell viability assay.
96
Total Activities
95
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A-375 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 96 | 5.91 | 10.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 10.30 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 10.05 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 8.92 |
| CHEMBL507361 | MIRDAMETINIB | 2.0 | 1 | 8.57 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 8.46 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 8.43 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 8.38 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 8.04 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 7.66 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 7.63 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 7.62 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 7.42 |
| CHEMBL575448 | BMS-754807 | 2.0 | 1 | 7.17 |
| CHEMBL6067492 | BLEOMYCIN | 4.0 | 1 | 7.15 |
| CHEMBL217354 | — | — | 1 | 7.05 |
| CHEMBL3349342 | — | — | 1 | 6.92 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 6.89 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 6.86 |
| CHEMBL477989 | SB590885 | — | 1 | 6.55 |
| CHEMBL9470 | SHIKONIN | — | 1 | 6.51 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 6.48 |
| CHEMBL803 | CYTARABINE | 4.0 | 1 | 6.40 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 6.35 |
| CHEMBL1091644 | LINSITINIB | 3.0 | 1 | 6.32 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 6.30 |
| CHEMBL608533 | MIDOSTAURIN | 4.0 | 1 | 6.25 |
| CHEMBL585951 | — | — | 1 | 6.21 |
| CHEMBL289228 | TIPIFARNIB | 3.0 | 1 | 6.21 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 6.20 |
| CHEMBL1230020 | PLX-4720 | — | 1 | 6.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL94657 | PATUPILONE | IC50 | = | 0.04997 | nM | 10.30 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 0.08921 | nM | 10.05 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 1.208 | nM | 8.92 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 2.687 | nM | 8.57 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 3.495 | nM | 8.46 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 3.688 | nM | 8.43 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 4.143 | nM | 8.38 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 9.168 | nM | 8.04 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 21.71 | nM | 7.66 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 23.53 | nM | 7.63 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 23.93 | nM | 7.62 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 38.21 | nM | 7.42 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 66.78 | nM | 7.17 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 71.1 | nM | 7.15 |
| CHEMBL217354 | — | IC50 | = | 88.83 | nM | 7.05 |
| CHEMBL3349342 | — | IC50 | = | 120.09 | nM | 6.92 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 127.78 | nM | 6.89 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 139.42 | nM | 6.86 |
| CHEMBL477989 | SB590885 | IC50 | = | 281.54 | nM | 6.55 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 311.11 | nM | 6.51 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 332.22 | nM | 6.48 |
| CHEMBL803 | CYTARABINE | IC50 | = | 395.67 | nM | 6.40 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 450.97 | nM | 6.35 |
| CHEMBL1091644 | LINSITINIB | IC50 | = | 476.17 | nM | 6.32 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 499.22 | nM | 6.30 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 561.03 | nM | 6.25 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 616.48 | nM | 6.21 |
| CHEMBL585951 | — | IC50 | = | 622.88 | nM | 6.21 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 630.84 | nM | 6.20 |
| CHEMBL1230020 | PLX-4720 | IC50 | = | 673.59 | nM | 6.17 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 751.93 | nM | 6.12 |
| CHEMBL591429 | PAC-1 | IC50 | = | 868.85 | nM | 6.06 |
| CHEMBL1190711 | — | IC50 | = | 1268.23 | nM | 5.90 |
| CHEMBL577784 | BX-795 | IC50 | = | 1308.58 | nM | 5.88 |
| CHEMBL379975 | — | IC50 | = | 1522.24 | nM | 5.82 |
| CHEMBL288441 | BOSUTINIB | IC50 | = | 1517.72 | nM | 5.82 |
| CHEMBL105442 | CI-1040 | IC50 | = | 1897.14 | nM | 5.72 |
| CHEMBL399530 | — | IC50 | = | 3082.56 | nM | 5.51 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 3081.84 | nM | 5.51 |
| CHEMBL2363137 | — | IC50 | = | 3580.12 | nM | 5.45 |
| CHEMBL221137 | EMBELIN | IC50 | = | 3572.46 | nM | 5.45 |
| CHEMBL202721 | — | IC50 | = | 3848.16 | nM | 5.42 |
| CHEMBL573107 | — | IC50 | = | 4051.62 | nM | 5.39 |
| CHEMBL191334 | NUTLIN-3 | IC50 | = | 4335.24 | nM | 5.36 |
| CHEMBL521851 | PICTILISIB | IC50 | = | 5092.56 | nM | 5.29 |
| CHEMBL558642 | GSK-650394 | IC50 | = | 5254.92 | nM | 5.28 |
| CHEMBL259181 | — | IC50 | = | 6869.33 | nM | 5.16 |
| CHEMBL2137530 | SERDEMETAN | IC50 | = | 9802.84 | nM | 5.01 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 9816.46 | nM | 5.01 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 10245.25 | nM | 4.99 |