Assay Detail
Functional
CHEMBL2363727
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SANGER: Inhibition of human A388 cell growth in a cell viability assay.
139
Total Activities
137
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A388 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 139 | 5.63 | 9.45 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 9.45 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 9.03 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 8.87 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 8.86 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 8.58 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 8.22 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 8.16 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.06 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 8.00 |
| CHEMBL514499 | GW843682X | — | 1 | 7.82 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 7.67 |
| CHEMBL513909 | BI-2536 | 2.0 | 1 | 7.65 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.55 |
| CHEMBL413 | SIROLIMUS | 4.0 | 1 | 7.35 |
| CHEMBL300389 | — | — | 1 | 7.32 |
| CHEMBL5416410 | DASATINIB | 4.0 | 1 | 7.29 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 7.25 |
| CHEMBL1256459 | TORIN1 | — | 1 | 7.16 |
| CHEMBL379300 | A-443654 | — | 1 | 7.07 |
| CHEMBL64925 | MG-132 | — | 2 | 7.04 |
| CHEMBL217354 | — | — | 1 | 6.78 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 6.68 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 6.60 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 6.58 |
| CHEMBL572878 | TOZASERTIB | 2.0 | 1 | 6.47 |
| CHEMBL1173655 | AFATINIB | 4.0 | 1 | 6.43 |
| CHEMBL392695 | S-TRITYL-L-CYSTEINE | — | 1 | 6.21 |
| CHEMBL554 | LAPATINIB | 4.0 | 1 | 6.14 |
| CHEMBL803 | CYTARABINE | 4.0 | 1 | 6.13 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 6.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 0.3558 | nM | 9.45 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 0.9397 | nM | 9.03 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 1.365 | nM | 8.87 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 1.388 | nM | 8.86 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 2.652 | nM | 8.58 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 6.067 | nM | 8.22 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 6.915 | nM | 8.16 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 8.738 | nM | 8.06 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 10.12 | nM | 8.00 |
| CHEMBL514499 | GW843682X | IC50 | = | 15.23 | nM | 7.82 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 21.15 | nM | 7.67 |
| CHEMBL513909 | BI-2536 | IC50 | = | 22.27 | nM | 7.65 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 28.46 | nM | 7.55 |
| CHEMBL413 | SIROLIMUS | IC50 | = | 44.82 | nM | 7.35 |
| CHEMBL300389 | — | IC50 | = | 47.74 | nM | 7.32 |
| CHEMBL5416410 | DASATINIB | IC50 | = | 50.95 | nM | 7.29 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 56.95 | nM | 7.25 |
| CHEMBL1256459 | TORIN1 | IC50 | = | 68.93 | nM | 7.16 |
| CHEMBL379300 | A-443654 | IC50 | = | 84.33 | nM | 7.07 |
| CHEMBL64925 | MG-132 | IC50 | = | 90.65 | nM | 7.04 |
| CHEMBL217354 | — | IC50 | = | 167.28 | nM | 6.78 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 207.22 | nM | 6.68 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 249.82 | nM | 6.60 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 264.15 | nM | 6.58 |
| CHEMBL572878 | TOZASERTIB | IC50 | = | 340.86 | nM | 6.47 |
| CHEMBL1173655 | AFATINIB | IC50 | = | 368.57 | nM | 6.43 |
| CHEMBL392695 | S-TRITYL-L-CYSTEINE | IC50 | = | 620.44 | nM | 6.21 |
| CHEMBL554 | LAPATINIB | IC50 | = | 722.58 | nM | 6.14 |
| CHEMBL803 | CYTARABINE | IC50 | = | 739.92 | nM | 6.13 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 764.67 | nM | 6.12 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 864.57 | nM | 6.06 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 877.18 | nM | 6.06 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 866.56 | nM | 6.06 |
| CHEMBL553 | ERLOTINIB | IC50 | = | 1093.8 | nM | 5.96 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 1529.44 | nM | 5.82 |
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 1519.45 | nM | 5.82 |
| CHEMBL1336 | SORAFENIB | IC50 | = | 1591.65 | nM | 5.80 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 1605.0 | nM | 5.79 |
| CHEMBL443684 | NAVITOCLAX | IC50 | = | 1687.24 | nM | 5.77 |
| CHEMBL585951 | — | IC50 | = | 1940.94 | nM | 5.71 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 2192.71 | nM | 5.66 |
| CHEMBL515416 | — | IC50 | = | 2190.27 | nM | 5.66 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 2652.53 | nM | 5.58 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 2943.09 | nM | 5.53 |
| CHEMBL509032 | TAE-684 | IC50 | = | 2961.7 | nM | 5.53 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 3329.57 | nM | 5.48 |
| CHEMBL202721 | — | IC50 | = | 3500.66 | nM | 5.46 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 4292.69 | nM | 5.37 |
| CHEMBL197603 | — | IC50 | = | 4340.93 | nM | 5.36 |
| CHEMBL64925 | MG-132 | IC50 | = | 4395.07 | nM | 5.36 |