Assay Detail
Functional
CHEMBL2363734
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SANGER: Inhibition of human A704 cell growth in a cell viability assay.
118
Total Activities
117
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A704 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 118 | 5.51 | 8.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL213100 | — | — | 1 | 8.90 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 7.84 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 7.84 |
| CHEMBL5416410 | DASATINIB | 4.0 | 1 | 7.83 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 7.81 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 7.56 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 7.27 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 7.25 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 7.04 |
| CHEMBL1256459 | TORIN1 | — | 1 | 7.01 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 6.92 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 6.61 |
| CHEMBL379300 | A-443654 | — | 1 | 6.58 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 6.50 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 6.46 |
| CHEMBL608533 | MIDOSTAURIN | 4.0 | 1 | 6.39 |
| CHEMBL443684 | NAVITOCLAX | 3.0 | 1 | 6.37 |
| CHEMBL585951 | — | — | 1 | 6.36 |
| CHEMBL64925 | MG-132 | — | 1 | 6.31 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 6.27 |
| CHEMBL300389 | — | — | 1 | 6.25 |
| CHEMBL1801204 | AZD-8055 | 1.0 | 1 | 6.09 |
| CHEMBL413 | SIROLIMUS | 4.0 | 1 | 6.05 |
| CHEMBL217092 | SARACATINIB | 3.0 | 1 | 6.05 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 6.01 |
| CHEMBL401930 | — | — | 1 | 5.98 |
| CHEMBL197603 | — | — | 1 | 5.94 |
| CHEMBL509032 | TAE-684 | — | 1 | 5.88 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 5.82 |
| CHEMBL521851 | PICTILISIB | 2.0 | 1 | 5.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL213100 | — | IC50 | = | 1.268 | nM | 8.90 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 14.6 | nM | 7.84 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 14.38 | nM | 7.84 |
| CHEMBL5416410 | DASATINIB | IC50 | = | 14.91 | nM | 7.83 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 15.35 | nM | 7.81 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 27.45 | nM | 7.56 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 53.78 | nM | 7.27 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 55.59 | nM | 7.25 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 91.5 | nM | 7.04 |
| CHEMBL1256459 | TORIN1 | IC50 | = | 97.41 | nM | 7.01 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 119.71 | nM | 6.92 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 247.44 | nM | 6.61 |
| CHEMBL379300 | A-443654 | IC50 | = | 260.96 | nM | 6.58 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 319.78 | nM | 6.50 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 349.23 | nM | 6.46 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 409.17 | nM | 6.39 |
| CHEMBL443684 | NAVITOCLAX | IC50 | = | 426.7 | nM | 6.37 |
| CHEMBL585951 | — | IC50 | = | 441.38 | nM | 6.36 |
| CHEMBL64925 | MG-132 | IC50 | = | 486.92 | nM | 6.31 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 538.81 | nM | 6.27 |
| CHEMBL300389 | — | IC50 | = | 557.42 | nM | 6.25 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 817.98 | nM | 6.09 |
| CHEMBL413 | SIROLIMUS | IC50 | = | 899.15 | nM | 6.05 |
| CHEMBL217092 | SARACATINIB | IC50 | = | 892.1 | nM | 6.05 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 967.23 | nM | 6.01 |
| CHEMBL401930 | — | IC50 | = | 1041.5 | nM | 5.98 |
| CHEMBL197603 | — | IC50 | = | 1147.87 | nM | 5.94 |
| CHEMBL509032 | TAE-684 | IC50 | = | 1326.89 | nM | 5.88 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 1511.91 | nM | 5.82 |
| CHEMBL521851 | PICTILISIB | IC50 | = | 1507.85 | nM | 5.82 |
| CHEMBL477772 | PAZOPANIB | IC50 | = | 1603.23 | nM | 5.79 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 1665.63 | nM | 5.78 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 1683.11 | nM | 5.77 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 2291.35 | nM | 5.64 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 2345.0 | nM | 5.63 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 2383.11 | nM | 5.62 |
| CHEMBL2363137 | — | IC50 | = | 2581.06 | nM | 5.59 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 2704.66 | nM | 5.57 |
| CHEMBL514499 | GW843682X | IC50 | = | 2699.76 | nM | 5.57 |
| CHEMBL412142 | LADUVIGLUSIB | IC50 | = | 3081.2 | nM | 5.51 |
| CHEMBL513909 | BI-2536 | IC50 | = | 3141.94 | nM | 5.50 |
| CHEMBL2165191 | AZD-6482 | IC50 | = | 3314.74 | nM | 5.48 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 3688.06 | nM | 5.43 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 3857.83 | nM | 5.41 |
| CHEMBL189584 | PD-173074 | IC50 | = | 4287.23 | nM | 5.37 |
| CHEMBL188678 | — | IC50 | = | 4408.88 | nM | 5.36 |
| CHEMBL3349342 | — | IC50 | = | 4695.43 | nM | 5.33 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 5030.6 | nM | 5.30 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 5841.37 | nM | 5.23 |
| CHEMBL1289926 | AXITINIB | IC50 | = | 6105.74 | nM | 5.21 |