Assay Detail
Functional
CHEMBL2363735
Review assay metadata, readout intent, target linkage, and publication context from the same page.
SANGER: Inhibition of human ABC-1 cell growth in a cell viability assay.
99
Total Activities
98
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | ABC-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 99 | 5.69 | 9.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 9.44 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 8.78 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 8.52 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 8.50 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 8.46 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 7.94 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 7.81 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 7.64 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 7.21 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.08 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 7.06 |
| CHEMBL575448 | BMS-754807 | 2.0 | 1 | 6.93 |
| CHEMBL507361 | MIRDAMETINIB | 2.0 | 1 | 6.91 |
| CHEMBL608533 | MIDOSTAURIN | 4.0 | 1 | 6.87 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 6.86 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 6.58 |
| CHEMBL217354 | — | — | 1 | 6.50 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 6.49 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 6.39 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 6.38 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 6.30 |
| CHEMBL9470 | SHIKONIN | — | 1 | 6.15 |
| CHEMBL585951 | — | — | 1 | 6.05 |
| CHEMBL1091644 | LINSITINIB | 3.0 | 1 | 6.04 |
| CHEMBL202721 | — | — | 1 | 5.85 |
| CHEMBL803 | CYTARABINE | 4.0 | 1 | 5.82 |
| CHEMBL189963 | PALBOCICLIB | 4.0 | 1 | 5.75 |
| CHEMBL1084546 | PF-00562271 | 1.0 | 1 | 5.65 |
| CHEMBL1079175 | MK-2206 | 2.0 | 1 | 5.63 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 0.3653 | nM | 9.44 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 1.675 | nM | 8.78 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 3.024 | nM | 8.52 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 3.192 | nM | 8.50 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 3.468 | nM | 8.46 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 11.46 | nM | 7.94 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 15.49 | nM | 7.81 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 22.65 | nM | 7.64 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 61.2 | nM | 7.21 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 83.45 | nM | 7.08 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 87.59 | nM | 7.06 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 116.95 | nM | 6.93 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 123.02 | nM | 6.91 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 134.15 | nM | 6.87 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 138.29 | nM | 6.86 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 260.64 | nM | 6.58 |
| CHEMBL217354 | — | IC50 | = | 315.5 | nM | 6.50 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 320.37 | nM | 6.49 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 404.53 | nM | 6.39 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 420.45 | nM | 6.38 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 504.96 | nM | 6.30 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 707.48 | nM | 6.15 |
| CHEMBL585951 | — | IC50 | = | 888.71 | nM | 6.05 |
| CHEMBL1091644 | LINSITINIB | IC50 | = | 903.52 | nM | 6.04 |
| CHEMBL202721 | — | IC50 | = | 1403.52 | nM | 5.85 |
| CHEMBL803 | CYTARABINE | IC50 | = | 1520.53 | nM | 5.82 |
| CHEMBL189963 | PALBOCICLIB | IC50 | = | 1785.82 | nM | 5.75 |
| CHEMBL1084546 | PF-00562271 | IC50 | = | 2251.96 | nM | 5.65 |
| CHEMBL1079175 | MK-2206 | IC50 | = | 2332.53 | nM | 5.63 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 2604.6 | nM | 5.58 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 3212.08 | nM | 5.49 |
| CHEMBL2363137 | — | IC50 | = | 3407.46 | nM | 5.47 |
| CHEMBL11359 | CISPLATIN | IC50 | = | 3608.03 | nM | 5.44 |
| CHEMBL1289926 | AXITINIB | IC50 | = | 3939.11 | nM | 5.41 |
| CHEMBL288441 | BOSUTINIB | IC50 | = | 4233.33 | nM | 5.37 |
| CHEMBL577784 | BX-795 | IC50 | = | 4811.73 | nM | 5.32 |
| CHEMBL176544 | — | IC50 | = | 5722.0 | nM | 5.24 |
| CHEMBL558642 | GSK-650394 | IC50 | = | 6583.02 | nM | 5.18 |
| CHEMBL191384 | — | IC50 | = | 9725.33 | nM | 5.01 |
| CHEMBL2134202 | — | IC50 | = | 10103.74 | nM | 5.00 |
| CHEMBL1190711 | — | IC50 | = | 10208.09 | nM | 4.99 |
| CHEMBL258844 | — | IC50 | = | 10285.48 | nM | 4.99 |
| CHEMBL939 | GEFITINIB | IC50 | = | 12340.99 | nM | 4.91 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 12506.61 | nM | 4.90 |
| CHEMBL2165191 | AZD-6482 | IC50 | = | 14750.44 | nM | 4.83 |
| CHEMBL259181 | — | IC50 | = | 14818.67 | nM | 4.83 |
| CHEMBL2137530 | SERDEMETAN | IC50 | = | 15944.92 | nM | 4.80 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 15803.29 | nM | 4.80 |
| CHEMBL443684 | NAVITOCLAX | IC50 | = | 17814.06 | nM | 4.75 |
| CHEMBL393929 | — | IC50 | = | 18562.68 | nM | 4.73 |