Assay Detail
Functional
CHEMBL2363737
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SANGER: Inhibition of human ACN cell growth in a cell viability assay.
139
Total Activities
137
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | ACN |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 139 | 5.87 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2144069 | — | — | 1 | 10.00 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 9.61 |
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 9.38 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 8.97 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 8.88 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.50 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 8.33 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 8.19 |
| CHEMBL513909 | BI-2536 | 2.0 | 1 | 8.07 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 7.95 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 7.93 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 7.88 |
| CHEMBL1256459 | TORIN1 | — | 1 | 7.82 |
| CHEMBL507361 | MIRDAMETINIB | 2.0 | 1 | 7.80 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 7.78 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 7.67 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.51 |
| CHEMBL514499 | GW843682X | — | 1 | 7.48 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 7.39 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 7.38 |
| CHEMBL3349342 | — | — | 1 | 7.19 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 7.11 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 7.10 |
| CHEMBL585951 | — | — | 1 | 7.10 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 7.09 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 7.07 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 6.89 |
| CHEMBL413 | SIROLIMUS | 4.0 | 1 | 6.83 |
| CHEMBL300389 | — | — | 1 | 6.78 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 6.76 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2144069 | — | IC50 | = | 0.1009 | nM | 10.00 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 0.2436 | nM | 9.61 |
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 0.4171 | nM | 9.38 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 1.068 | nM | 8.97 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 1.329 | nM | 8.88 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 3.157 | nM | 8.50 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 4.69 | nM | 8.33 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 6.438 | nM | 8.19 |
| CHEMBL513909 | BI-2536 | IC50 | = | 8.434 | nM | 8.07 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 11.31 | nM | 7.95 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 11.72 | nM | 7.93 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 13.02 | nM | 7.88 |
| CHEMBL1256459 | TORIN1 | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 15.76 | nM | 7.80 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 16.57 | nM | 7.78 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 21.5 | nM | 7.67 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 31.12 | nM | 7.51 |
| CHEMBL514499 | GW843682X | IC50 | = | 33.29 | nM | 7.48 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 40.29 | nM | 7.39 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 41.62 | nM | 7.38 |
| CHEMBL3349342 | — | IC50 | = | 65.06 | nM | 7.19 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 77.69 | nM | 7.11 |
| CHEMBL585951 | — | IC50 | = | 78.63 | nM | 7.10 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 78.96 | nM | 7.10 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 81.84 | nM | 7.09 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 85.66 | nM | 7.07 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 127.91 | nM | 6.89 |
| CHEMBL413 | SIROLIMUS | IC50 | = | 146.75 | nM | 6.83 |
| CHEMBL300389 | — | IC50 | = | 165.47 | nM | 6.78 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 171.71 | nM | 6.76 |
| CHEMBL64925 | MG-132 | IC50 | = | 226.38 | nM | 6.64 |
| CHEMBL105442 | CI-1040 | IC50 | = | 267.37 | nM | 6.57 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 348.73 | nM | 6.46 |
| CHEMBL1230020 | PLX-4720 | IC50 | = | 384.77 | nM | 6.42 |
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 510.28 | nM | 6.29 |
| CHEMBL1173655 | AFATINIB | IC50 | = | 550.94 | nM | 6.26 |
| CHEMBL1614701 | SELUMETINIB | IC50 | = | 566.9 | nM | 6.25 |
| CHEMBL939 | GEFITINIB | IC50 | = | 580.76 | nM | 6.24 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 648.32 | nM | 6.19 |
| CHEMBL217354 | — | IC50 | = | 696.01 | nM | 6.16 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 808.34 | nM | 6.09 |
| CHEMBL176544 | — | IC50 | = | 865.09 | nM | 6.06 |
| CHEMBL379300 | A-443654 | IC50 | = | 908.85 | nM | 6.04 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 916.95 | nM | 6.04 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 942.77 | nM | 6.03 |
| CHEMBL477989 | SB590885 | IC50 | = | 1148.84 | nM | 5.94 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 1460.84 | nM | 5.83 |
| CHEMBL392695 | S-TRITYL-L-CYSTEINE | IC50 | = | 1464.33 | nM | 5.83 |
| CHEMBL255863 | NILOTINIB | IC50 | = | 1550.77 | nM | 5.81 |
| CHEMBL38 | TRETINOIN | IC50 | = | 1649.99 | nM | 5.78 |