Assay Detail
Functional
CHEMBL2363740
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SANGER: Inhibition of human AM-38 cell growth in a cell viability assay.
139
Total Activities
137
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | AM-38 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 139 | 5.42 | 9.91 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 9.91 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 8.36 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 8.12 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 7.99 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 7.88 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 7.83 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 7.47 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 7.43 |
| CHEMBL512504 | — | — | 1 | 7.19 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 7.16 |
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 7.05 |
| CHEMBL9470 | SHIKONIN | — | 1 | 7.02 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 6.77 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 6.72 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 6.68 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 6.66 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.55 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 6.39 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 6.22 |
| CHEMBL608533 | MIDOSTAURIN | 4.0 | 1 | 6.14 |
| CHEMBL217354 | — | — | 1 | 6.08 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 6.03 |
| CHEMBL585951 | — | — | 1 | 5.95 |
| CHEMBL413 | SIROLIMUS | 4.0 | 1 | 5.88 |
| CHEMBL1801204 | AZD-8055 | 1.0 | 1 | 5.86 |
| CHEMBL507361 | MIRDAMETINIB | 2.0 | 1 | 5.85 |
| CHEMBL803 | CYTARABINE | 4.0 | 1 | 5.83 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 5.66 |
| CHEMBL575448 | BMS-754807 | 2.0 | 1 | 5.64 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.56 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL888 | GEMCITABINE | IC50 | = | 0.1215 | nM | 9.91 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 4.408 | nM | 8.36 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 7.564 | nM | 8.12 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 10.24 | nM | 7.99 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 13.02 | nM | 7.88 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 14.81 | nM | 7.83 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 33.55 | nM | 7.47 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 36.92 | nM | 7.43 |
| CHEMBL512504 | — | IC50 | = | 64.4 | nM | 7.19 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 69.31 | nM | 7.16 |
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 88.08 | nM | 7.05 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 96.31 | nM | 7.02 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 168.78 | nM | 6.77 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 192.25 | nM | 6.72 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 208.48 | nM | 6.68 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 221.16 | nM | 6.66 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 281.52 | nM | 6.55 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 408.09 | nM | 6.39 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 603.87 | nM | 6.22 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 728.71 | nM | 6.14 |
| CHEMBL217354 | — | IC50 | = | 840.89 | nM | 6.08 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 940.4 | nM | 6.03 |
| CHEMBL585951 | — | IC50 | = | 1111.77 | nM | 5.95 |
| CHEMBL413 | SIROLIMUS | IC50 | = | 1307.2 | nM | 5.88 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 1371.99 | nM | 5.86 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 1404.48 | nM | 5.85 |
| CHEMBL803 | CYTARABINE | IC50 | = | 1467.55 | nM | 5.83 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 2170.15 | nM | 5.66 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 2277.15 | nM | 5.64 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 2773.55 | nM | 5.56 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 2940.3 | nM | 5.53 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 3380.51 | nM | 5.47 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 3667.06 | nM | 5.44 |
| CHEMBL300389 | — | IC50 | = | 3840.53 | nM | 5.42 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 4941.12 | nM | 5.31 |
| CHEMBL191334 | NUTLIN-3 | IC50 | = | 6756.39 | nM | 5.17 |
| CHEMBL220241 | GSK-269962A | IC50 | = | 7263.27 | nM | 5.14 |
| CHEMBL939 | GEFITINIB | IC50 | = | 8162.8 | nM | 5.09 |
| CHEMBL1084546 | PF-00562271 | IC50 | = | 8804.39 | nM | 5.05 |
| CHEMBL3349342 | — | IC50 | = | 11244.68 | nM | 4.95 |
| CHEMBL221137 | EMBELIN | IC50 | = | 12458.17 | nM | 4.91 |
| CHEMBL64925 | MG-132 | IC50 | = | 12563.31 | nM | 4.90 |
| CHEMBL2165191 | AZD-6482 | IC50 | = | 12938.73 | nM | 4.89 |
| CHEMBL443684 | NAVITOCLAX | IC50 | = | 13256.63 | nM | 4.88 |
| CHEMBL1190711 | — | IC50 | = | 13214.61 | nM | 4.88 |
| CHEMBL105442 | CI-1040 | IC50 | = | 15271.69 | nM | 4.82 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 15416.65 | nM | 4.81 |
| CHEMBL577784 | BX-795 | IC50 | = | 15485.3 | nM | 4.81 |
| CHEMBL2137530 | SERDEMETAN | IC50 | = | 15455.59 | nM | 4.81 |
| CHEMBL1090090 | VX-702 | IC50 | = | 15984.68 | nM | 4.80 |