Assay Detail
Functional
CHEMBL2363751
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SANGER: Inhibition of human BC-3 cell growth in a cell viability assay.
78
Total Activities
77
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | BC-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 78 | 5.68 | 8.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 8.35 |
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 8.18 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 8.08 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 7.63 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 7.52 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 7.51 |
| CHEMBL300389 | — | — | 1 | 7.12 |
| CHEMBL1256459 | TORIN1 | — | 1 | 7.09 |
| CHEMBL513909 | BI-2536 | 2.0 | 1 | 7.01 |
| CHEMBL413 | SIROLIMUS | 4.0 | 1 | 7.00 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.78 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 6.67 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 6.66 |
| CHEMBL379300 | A-443654 | — | 1 | 6.47 |
| CHEMBL514499 | GW843682X | — | 1 | 6.33 |
| CHEMBL608533 | MIDOSTAURIN | 4.0 | 1 | 6.31 |
| CHEMBL6067492 | BLEOMYCIN | 4.0 | 1 | 6.28 |
| CHEMBL585951 | — | — | 1 | 6.22 |
| CHEMBL27759 | ENTINOSTAT | 3.0 | 1 | 6.11 |
| CHEMBL9470 | SHIKONIN | — | 1 | 6.03 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 5.88 |
| CHEMBL558642 | GSK-650394 | — | 1 | 5.73 |
| CHEMBL392695 | S-TRITYL-L-CYSTEINE | — | 1 | 5.66 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 5.63 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 5.61 |
| CHEMBL1190711 | — | — | 1 | 5.61 |
| CHEMBL289228 | TIPIFARNIB | 3.0 | 1 | 5.53 |
| CHEMBL509032 | TAE-684 | — | 1 | 5.38 |
| CHEMBL1336 | SORAFENIB | 4.0 | 1 | 5.37 |
| CHEMBL401930 | — | — | 1 | 5.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 4.511 | nM | 8.35 |
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 6.612 | nM | 8.18 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 8.389 | nM | 8.08 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 23.44 | nM | 7.63 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 30.18 | nM | 7.52 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 31.12 | nM | 7.51 |
| CHEMBL300389 | — | IC50 | = | 76.56 | nM | 7.12 |
| CHEMBL1256459 | TORIN1 | IC50 | = | 82.04 | nM | 7.09 |
| CHEMBL513909 | BI-2536 | IC50 | = | 96.62 | nM | 7.01 |
| CHEMBL413 | SIROLIMUS | IC50 | = | 99.18 | nM | 7.00 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 165.86 | nM | 6.78 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 212.08 | nM | 6.67 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 220.65 | nM | 6.66 |
| CHEMBL379300 | A-443654 | IC50 | = | 342.35 | nM | 6.47 |
| CHEMBL514499 | GW843682X | IC50 | = | 471.62 | nM | 6.33 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 487.41 | nM | 6.31 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 521.0 | nM | 6.28 |
| CHEMBL585951 | — | IC50 | = | 598.13 | nM | 6.22 |
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 783.08 | nM | 6.11 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 926.19 | nM | 6.03 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 1328.37 | nM | 5.88 |
| CHEMBL558642 | GSK-650394 | IC50 | = | 1870.94 | nM | 5.73 |
| CHEMBL392695 | S-TRITYL-L-CYSTEINE | IC50 | = | 2190.25 | nM | 5.66 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 2365.09 | nM | 5.63 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 2475.45 | nM | 5.61 |
| CHEMBL1190711 | — | IC50 | = | 2468.57 | nM | 5.61 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 2978.24 | nM | 5.53 |
| CHEMBL509032 | TAE-684 | IC50 | = | 4130.68 | nM | 5.38 |
| CHEMBL1336 | SORAFENIB | IC50 | = | 4233.91 | nM | 5.37 |
| CHEMBL401930 | — | IC50 | = | 4339.05 | nM | 5.36 |
| CHEMBL1084546 | PF-00562271 | IC50 | = | 4434.77 | nM | 5.35 |
| CHEMBL2144069 | — | IC50 | = | 5254.52 | nM | 5.28 |
| CHEMBL591429 | PAC-1 | IC50 | = | 6294.25 | nM | 5.20 |
| CHEMBL259181 | — | IC50 | = | 6662.21 | nM | 5.18 |
| CHEMBL191384 | — | IC50 | = | 7458.66 | nM | 5.13 |
| CHEMBL2363137 | — | IC50 | = | 8378.13 | nM | 5.08 |
| CHEMBL1673039 | — | IC50 | = | 8411.7 | nM | 5.08 |
| CHEMBL1643959 | — | IC50 | = | 9062.77 | nM | 5.04 |
| CHEMBL5416410 | DASATINIB | IC50 | = | 12113.76 | nM | 4.92 |
| CHEMBL2165191 | AZD-6482 | IC50 | = | 12291.96 | nM | 4.91 |
| CHEMBL535 | SUNITINIB | IC50 | = | 12465.08 | nM | 4.90 |
| CHEMBL515416 | — | IC50 | = | 12900.38 | nM | 4.89 |
| CHEMBL180127 | SALUBRINAL | IC50 | = | 14798.18 | nM | 4.83 |
| CHEMBL64925 | MG-132 | IC50 | = | 15398.01 | nM | 4.81 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 16372.3 | nM | 4.79 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 16056.17 | nM | 4.79 |
| CHEMBL64925 | MG-132 | IC50 | = | 16565.99 | nM | 4.78 |
| CHEMBL14762 | SELICICLIB | IC50 | = | 18030.54 | nM | 4.74 |
| CHEMBL36 | PYRIMETHAMINE | IC50 | = | 19477.66 | nM | 4.71 |
| CHEMBL1091644 | LINSITINIB | IC50 | = | 32140.28 | nM | 4.49 |