Assay Detail
Functional
CHEMBL2363753
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SANGER: Inhibition of human BE-13 cell growth in a cell viability assay.
130
Total Activities
129
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | BE-13 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 130 | 5.89 | 9.78 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 9.78 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 8.85 |
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 8.71 |
| CHEMBL1171837 | PONATINIB | 4.0 | 1 | 8.59 |
| CHEMBL413 | SIROLIMUS | 4.0 | 1 | 8.53 |
| CHEMBL572878 | TOZASERTIB | 2.0 | 1 | 8.47 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 8.40 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 8.34 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 8.31 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 8.28 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.20 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 8.14 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 8.13 |
| CHEMBL514499 | GW843682X | — | 1 | 7.96 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 7.91 |
| CHEMBL513909 | BI-2536 | 2.0 | 1 | 7.56 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 7.50 |
| CHEMBL1256459 | TORIN1 | — | 1 | 7.42 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 7.41 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.29 |
| CHEMBL300389 | — | — | 1 | 7.11 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 6.89 |
| CHEMBL220241 | GSK-269962A | — | 1 | 6.85 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 6.70 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 6.57 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 6.55 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 6.47 |
| CHEMBL443684 | NAVITOCLAX | 3.0 | 1 | 6.44 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 6.41 |
| CHEMBL6067492 | BLEOMYCIN | 4.0 | 1 | 6.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL105 | MITOMYCIN | IC50 | = | 0.1673 | nM | 9.78 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 1.416 | nM | 8.85 |
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 1.93 | nM | 8.71 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 2.593 | nM | 8.59 |
| CHEMBL413 | SIROLIMUS | IC50 | = | 2.988 | nM | 8.53 |
| CHEMBL572878 | TOZASERTIB | IC50 | = | 3.38 | nM | 8.47 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 3.935 | nM | 8.40 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 4.564 | nM | 8.34 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 4.907 | nM | 8.31 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 5.21 | nM | 8.28 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 6.363 | nM | 8.20 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 7.296 | nM | 8.14 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 7.35 | nM | 8.13 |
| CHEMBL514499 | GW843682X | IC50 | = | 11.02 | nM | 7.96 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 12.37 | nM | 7.91 |
| CHEMBL513909 | BI-2536 | IC50 | = | 27.4 | nM | 7.56 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 31.82 | nM | 7.50 |
| CHEMBL1256459 | TORIN1 | IC50 | = | 37.59 | nM | 7.42 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 38.75 | nM | 7.41 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 51.02 | nM | 7.29 |
| CHEMBL300389 | — | IC50 | = | 76.87 | nM | 7.11 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 128.66 | nM | 6.89 |
| CHEMBL220241 | GSK-269962A | IC50 | = | 140.81 | nM | 6.85 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 201.17 | nM | 6.70 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 272.49 | nM | 6.57 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 279.63 | nM | 6.55 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 336.73 | nM | 6.47 |
| CHEMBL443684 | NAVITOCLAX | IC50 | = | 364.59 | nM | 6.44 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 391.58 | nM | 6.41 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 398.72 | nM | 6.40 |
| CHEMBL189963 | PALBOCICLIB | IC50 | = | 444.27 | nM | 6.35 |
| CHEMBL288441 | BOSUTINIB | IC50 | = | 485.72 | nM | 6.31 |
| CHEMBL379300 | A-443654 | IC50 | = | 502.24 | nM | 6.30 |
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 496.61 | nM | 6.30 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 503.68 | nM | 6.30 |
| CHEMBL1289926 | AXITINIB | IC50 | = | 510.08 | nM | 6.29 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 526.96 | nM | 6.28 |
| CHEMBL64925 | MG-132 | IC50 | = | 562.07 | nM | 6.25 |
| CHEMBL577784 | BX-795 | IC50 | = | 704.77 | nM | 6.15 |
| CHEMBL2144069 | — | IC50 | = | 805.75 | nM | 6.09 |
| CHEMBL803 | CYTARABINE | IC50 | = | 824.5 | nM | 6.08 |
| CHEMBL202721 | — | IC50 | = | 844.18 | nM | 6.07 |
| CHEMBL392695 | S-TRITYL-L-CYSTEINE | IC50 | = | 1083.41 | nM | 5.96 |
| CHEMBL585951 | — | IC50 | = | 1097.02 | nM | 5.96 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 1117.59 | nM | 5.95 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 1195.23 | nM | 5.92 |
| CHEMBL255863 | NILOTINIB | IC50 | = | 1274.16 | nM | 5.89 |
| CHEMBL939 | GEFITINIB | IC50 | = | 1506.71 | nM | 5.82 |
| CHEMBL573107 | — | IC50 | = | 1587.09 | nM | 5.80 |
| CHEMBL379975 | — | IC50 | = | 2618.06 | nM | 5.58 |