Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL2363759

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
SANGER: Inhibition of human BL-41 cell growth in a cell viability assay.
ChEMBL ↗
78
Total Activities
77
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type BL-41
Confidence 1 — Organism
Curated By Autocuration

Target

BL-41 (CHEMBL2366173) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute

· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 78 5.97 9.85

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL96926 THAPSIGARGIN — 1 9.85
CHEMBL325041 BORTEZOMIB 3.0 1 8.90
CHEMBL94657 PATUPILONE 3.0 1 8.87
CHEMBL553025 VINORELBINE 4.0 1 8.28
CHEMBL1256459 TORIN1 — 1 8.16
CHEMBL428647 PACLITAXEL 4.0 1 8.03
CHEMBL514499 GW843682X — 1 7.96
CHEMBL888 GEMCITABINE 4.0 1 7.84
CHEMBL300389 — — 1 7.47
CHEMBL513909 BI-2536 2.0 1 7.38
CHEMBL413 SIROLIMUS 4.0 1 7.36
CHEMBL252164 LUMINESPIB 2.0 1 7.25
CHEMBL2107358 OBATOCLAX MESYLATE 3.0 1 7.21
CHEMBL449158 BRYOSTATIN 1 2.0 1 7.19
CHEMBL64925 MG-132 — 2 7.16
CHEMBL379300 A-443654 — 1 7.02
CHEMBL572878 TOZASERTIB 2.0 1 6.98
CHEMBL53463 DOXORUBICIN 4.0 1 6.91
CHEMBL512504 — — 1 6.72
CHEMBL5416410 DASATINIB 4.0 1 6.54
CHEMBL105 MITOMYCIN 4.0 1 6.53
CHEMBL585951 — — 1 6.51
CHEMBL9470 SHIKONIN — 1 6.32
CHEMBL27759 ENTINOSTAT 3.0 1 6.25
CHEMBL1171837 PONATINIB 4.0 1 6.20
CHEMBL608533 MIDOSTAURIN 4.0 1 6.03
CHEMBL213100 — — 1 6.00
CHEMBL1190711 — — 1 5.86
CHEMBL591429 PAC-1 1.0 1 5.84
CHEMBL392695 S-TRITYL-L-CYSTEINE — 1 5.78

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL96926 THAPSIGARGIN IC50 = 0.1413 nM 9.85
CHEMBL325041 BORTEZOMIB IC50 = 1.25 nM 8.90
CHEMBL94657 PATUPILONE IC50 = 1.353 nM 8.87
CHEMBL553025 VINORELBINE IC50 = 5.28 nM 8.28
CHEMBL1256459 TORIN1 IC50 = 6.965 nM 8.16
CHEMBL428647 PACLITAXEL IC50 = 9.345 nM 8.03
CHEMBL514499 GW843682X IC50 = 10.91 nM 7.96
CHEMBL888 GEMCITABINE IC50 = 14.37 nM 7.84
CHEMBL300389 — IC50 = 33.63 nM 7.47
CHEMBL513909 BI-2536 IC50 = 41.25 nM 7.38
CHEMBL413 SIROLIMUS IC50 = 43.66 nM 7.36
CHEMBL252164 LUMINESPIB IC50 = 55.96 nM 7.25
CHEMBL2107358 OBATOCLAX MESYLATE IC50 = 62.19 nM 7.21
CHEMBL449158 BRYOSTATIN 1 IC50 = 64.98 nM 7.19
CHEMBL64925 MG-132 IC50 = 69.47 nM 7.16
CHEMBL379300 A-443654 IC50 = 96.35 nM 7.02
CHEMBL572878 TOZASERTIB IC50 = 104.45 nM 6.98
CHEMBL53463 DOXORUBICIN IC50 = 122.22 nM 6.91
CHEMBL512504 — IC50 = 189.43 nM 6.72
CHEMBL5416410 DASATINIB IC50 = 291.23 nM 6.54
CHEMBL105 MITOMYCIN IC50 = 294.9 nM 6.53
CHEMBL585951 — IC50 = 307.2 nM 6.51
CHEMBL9470 SHIKONIN IC50 = 483.4 nM 6.32
CHEMBL27759 ENTINOSTAT IC50 = 568.89 nM 6.25
CHEMBL1171837 PONATINIB IC50 = 633.52 nM 6.20
CHEMBL608533 MIDOSTAURIN IC50 = 925.39 nM 6.03
CHEMBL213100 — IC50 = 1000.13 nM 6.00
CHEMBL1190711 — IC50 = 1393.83 nM 5.86
CHEMBL591429 PAC-1 IC50 = 1450.4 nM 5.84
CHEMBL392695 S-TRITYL-L-CYSTEINE IC50 = 1643.55 nM 5.78
CHEMBL197603 — IC50 = 1689.4 nM 5.77
CHEMBL509032 TAE-684 IC50 = 1762.72 nM 5.75
CHEMBL44657 ETOPOSIDE IC50 = 2080.98 nM 5.68
CHEMBL64925 MG-132 IC50 = 2118.04 nM 5.67
CHEMBL289228 TIPIFARNIB IC50 = 2773.15 nM 5.56
CHEMBL535 SUNITINIB IC50 = 2912.22 nM 5.54
CHEMBL472940 — IC50 = 3098.44 nM 5.51
CHEMBL1673039 — IC50 = 3645.83 nM 5.44
CHEMBL259181 — IC50 = 3687.74 nM 5.43
CHEMBL1242367 — IC50 = 5529.74 nM 5.26
CHEMBL221137 EMBELIN IC50 = 5496.48 nM 5.26
CHEMBL412142 LADUVIGLUSIB IC50 = 5812.66 nM 5.24
CHEMBL401930 — IC50 = 6470.52 nM 5.19
CHEMBL191384 — IC50 = 7635.44 nM 5.12
CHEMBL2165191 AZD-6482 IC50 = 8548.66 nM 5.07
CHEMBL180127 SALUBRINAL IC50 = 9780.49 nM 5.01
CHEMBL1084546 PF-00562271 IC50 = 11717.34 nM 4.93
CHEMBL209148 — IC50 = 13141.13 nM 4.88
CHEMBL6067492 BLEOMYCIN IC50 = 14197.46 nM 4.85
CHEMBL558642 GSK-650394 IC50 = 17144.01 nM 4.77