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Assay Detail

CHEMBL2363774

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Functional
SANGER: Inhibition of human C8166 cell growth in a cell viability assay.
ChEMBL ↗
130
Total Activities
129
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type C8166
Confidence 1 — Organism
Curated By Autocuration

Target

C8166 (CHEMBL614533) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute

· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 130 5.32 7.95

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL252164 LUMINESPIB 2.0 1 7.95
CHEMBL888 GEMCITABINE 4.0 1 7.88
CHEMBL553025 VINORELBINE 4.0 1 7.75
CHEMBL159 VINBLASTINE 4.0 1 7.57
CHEMBL94657 PATUPILONE 3.0 1 7.50
CHEMBL53463 DOXORUBICIN 4.0 1 7.48
CHEMBL325041 BORTEZOMIB 3.0 1 7.45
CHEMBL65 CAMPTOTHECIN -1.0 1 7.38
CHEMBL512504 — — 1 7.18
CHEMBL96926 THAPSIGARGIN — 1 6.72
CHEMBL449158 BRYOSTATIN 1 2.0 1 6.69
CHEMBL34259 METHOTREXATE 4.0 1 6.65
CHEMBL9470 SHIKONIN — 1 6.39
CHEMBL585951 — — 1 6.35
CHEMBL2107358 OBATOCLAX MESYLATE 3.0 1 6.32
CHEMBL3545252 DOCETAXEL 4.0 1 6.31
CHEMBL105 MITOMYCIN 4.0 1 6.03
CHEMBL591429 PAC-1 1.0 1 5.91
CHEMBL44657 ETOPOSIDE 4.0 1 5.78
CHEMBL2041933 AZD-7762 1.0 1 5.72
CHEMBL1190711 — — 1 5.66
CHEMBL98 VORINOSTAT 4.0 1 5.66
CHEMBL1879463 DACTOLISIB 3.0 1 5.58
CHEMBL1171837 PONATINIB 4.0 1 5.55
CHEMBL939 GEFITINIB 4.0 1 5.46
CHEMBL1201182 TEMSIROLIMUS 4.0 1 5.44
CHEMBL608533 MIDOSTAURIN 4.0 1 5.35
CHEMBL1084546 PF-00562271 1.0 1 5.35
CHEMBL191384 — — 1 5.35
CHEMBL1972860 ELESCLOMOL 3.0 1 5.31

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL252164 LUMINESPIB IC50 = 11.29 nM 7.95
CHEMBL888 GEMCITABINE IC50 = 13.08 nM 7.88
CHEMBL553025 VINORELBINE IC50 = 17.56 nM 7.75
CHEMBL159 VINBLASTINE IC50 = 27.01 nM 7.57
CHEMBL94657 PATUPILONE IC50 = 31.69 nM 7.50
CHEMBL53463 DOXORUBICIN IC50 = 33.31 nM 7.48
CHEMBL325041 BORTEZOMIB IC50 = 35.7 nM 7.45
CHEMBL65 CAMPTOTHECIN IC50 = 41.48 nM 7.38
CHEMBL512504 — IC50 = 66.19 nM 7.18
CHEMBL96926 THAPSIGARGIN IC50 = 188.49 nM 6.72
CHEMBL449158 BRYOSTATIN 1 IC50 = 202.07 nM 6.69
CHEMBL34259 METHOTREXATE IC50 = 224.12 nM 6.65
CHEMBL9470 SHIKONIN IC50 = 407.51 nM 6.39
CHEMBL585951 — IC50 = 444.54 nM 6.35
CHEMBL2107358 OBATOCLAX MESYLATE IC50 = 474.0 nM 6.32
CHEMBL3545252 DOCETAXEL IC50 = 490.23 nM 6.31
CHEMBL105 MITOMYCIN IC50 = 932.32 nM 6.03
CHEMBL591429 PAC-1 IC50 = 1217.94 nM 5.91
CHEMBL44657 ETOPOSIDE IC50 = 1677.3 nM 5.78
CHEMBL2041933 AZD-7762 IC50 = 1909.32 nM 5.72
CHEMBL98 VORINOSTAT IC50 = 2213.34 nM 5.66
CHEMBL1190711 — IC50 = 2196.04 nM 5.66
CHEMBL1879463 DACTOLISIB IC50 = 2633.92 nM 5.58
CHEMBL1171837 PONATINIB IC50 = 2785.13 nM 5.55
CHEMBL939 GEFITINIB IC50 = 3465.21 nM 5.46
CHEMBL1201182 TEMSIROLIMUS IC50 = 3596.99 nM 5.44
CHEMBL1084546 PF-00562271 IC50 = 4477.53 nM 5.35
CHEMBL608533 MIDOSTAURIN IC50 = 4487.93 nM 5.35
CHEMBL191384 — IC50 = 4469.58 nM 5.35
CHEMBL1972860 ELESCLOMOL IC50 = 4946.03 nM 5.31
CHEMBL109480 TANESPIMYCIN IC50 = 5363.39 nM 5.27
CHEMBL2363137 — IC50 = 6097.44 nM 5.21
CHEMBL413 SIROLIMUS IC50 = 6559.12 nM 5.18
CHEMBL221137 EMBELIN IC50 = 7644.26 nM 5.12
CHEMBL6067492 BLEOMYCIN IC50 = 7770.36 nM 5.11
CHEMBL573107 — IC50 = 8867.72 nM 5.05
CHEMBL412142 LADUVIGLUSIB IC50 = 13231.85 nM 4.88
CHEMBL513909 BI-2536 IC50 = 13830.27 nM 4.86
CHEMBL507361 MIRDAMETINIB IC50 = 17739.29 nM 4.75
CHEMBL259181 — IC50 = 17697.72 nM 4.75
CHEMBL1336 SORAFENIB IC50 = 17683.29 nM 4.75
CHEMBL514499 GW843682X IC50 = 22602.96 nM 4.65
CHEMBL428647 PACLITAXEL IC50 = 22274.64 nM 4.65
CHEMBL2165191 AZD-6482 IC50 = 26743.7 nM 4.57
CHEMBL64925 MG-132 IC50 = 27935.27 nM 4.55
CHEMBL289228 TIPIFARNIB IC50 = 28375.78 nM 4.55
CHEMBL443684 NAVITOCLAX IC50 = 28693.83 nM 4.54
CHEMBL105442 CI-1040 IC50 = 29999.63 nM 4.52
CHEMBL848 LENALIDOMIDE IC50 = 31227.37 nM 4.50
CHEMBL189584 PD-173074 IC50 = 33319.21 nM 4.48