Assay Detail
Functional
CHEMBL2363776
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SANGER: Inhibition of human CAKI-1 cell growth in a cell viability assay.
99
Total Activities
98
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CAKI-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 99 | 5.47 | 8.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 8.27 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 7.97 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 7.76 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 7.63 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 7.62 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 7.61 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 7.44 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 7.16 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 7.08 |
| CHEMBL803 | CYTARABINE | 4.0 | 1 | 6.92 |
| CHEMBL217354 | — | — | 1 | 6.67 |
| CHEMBL608533 | MIDOSTAURIN | 4.0 | 1 | 6.67 |
| CHEMBL1171837 | PONATINIB | 4.0 | 1 | 6.66 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 6.60 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 6.54 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 6.49 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 6.48 |
| CHEMBL585951 | — | — | 1 | 6.48 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.42 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 6.33 |
| CHEMBL6067492 | BLEOMYCIN | 4.0 | 1 | 6.21 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 6.17 |
| CHEMBL1801204 | AZD-8055 | 1.0 | 1 | 6.13 |
| CHEMBL9470 | SHIKONIN | — | 1 | 6.05 |
| CHEMBL575448 | BMS-754807 | 2.0 | 1 | 5.94 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 5.90 |
| CHEMBL507361 | MIRDAMETINIB | 2.0 | 1 | 5.87 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 5.76 |
| CHEMBL1173655 | AFATINIB | 4.0 | 1 | 5.75 |
| CHEMBL577784 | BX-795 | — | 1 | 5.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 5.354 | nM | 8.27 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 10.73 | nM | 7.97 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 17.34 | nM | 7.76 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 23.32 | nM | 7.63 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 24.12 | nM | 7.62 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 24.61 | nM | 7.61 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 36.43 | nM | 7.44 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 68.72 | nM | 7.16 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 83.45 | nM | 7.08 |
| CHEMBL803 | CYTARABINE | IC50 | = | 120.01 | nM | 6.92 |
| CHEMBL217354 | — | IC50 | = | 216.44 | nM | 6.67 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 215.05 | nM | 6.67 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 216.66 | nM | 6.66 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 250.86 | nM | 6.60 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 286.8 | nM | 6.54 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 321.11 | nM | 6.49 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 334.09 | nM | 6.48 |
| CHEMBL585951 | — | IC50 | = | 333.99 | nM | 6.48 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 375.48 | nM | 6.42 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 465.17 | nM | 6.33 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 620.43 | nM | 6.21 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 671.49 | nM | 6.17 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 746.29 | nM | 6.13 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 894.13 | nM | 6.05 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 1143.46 | nM | 5.94 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 1271.28 | nM | 5.90 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 1353.24 | nM | 5.87 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 1722.92 | nM | 5.76 |
| CHEMBL1173655 | AFATINIB | IC50 | = | 1782.11 | nM | 5.75 |
| CHEMBL577784 | BX-795 | IC50 | = | 2280.58 | nM | 5.64 |
| CHEMBL191334 | NUTLIN-3 | IC50 | = | 3126.94 | nM | 5.50 |
| CHEMBL2165191 | AZD-6482 | IC50 | = | 3172.41 | nM | 5.50 |
| CHEMBL2137530 | SERDEMETAN | IC50 | = | 3527.38 | nM | 5.45 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 3890.52 | nM | 5.41 |
| CHEMBL288441 | BOSUTINIB | IC50 | = | 4245.71 | nM | 5.37 |
| CHEMBL1614701 | SELUMETINIB | IC50 | = | 4460.57 | nM | 5.35 |
| CHEMBL2165191 | AZD-6482 | IC50 | = | 4714.66 | nM | 5.33 |
| CHEMBL939 | GEFITINIB | IC50 | = | 6009.85 | nM | 5.22 |
| CHEMBL1190711 | — | IC50 | = | 6100.42 | nM | 5.21 |
| CHEMBL191384 | — | IC50 | = | 6477.53 | nM | 5.19 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 6652.87 | nM | 5.18 |
| CHEMBL11359 | CISPLATIN | IC50 | = | 7270.79 | nM | 5.14 |
| CHEMBL1084546 | PF-00562271 | IC50 | = | 8065.21 | nM | 5.09 |
| CHEMBL477772 | PAZOPANIB | IC50 | = | 8288.31 | nM | 5.08 |
| CHEMBL105442 | CI-1040 | IC50 | = | 8572.22 | nM | 5.07 |
| CHEMBL188678 | — | IC50 | = | 9166.1 | nM | 5.04 |
| CHEMBL189963 | PALBOCICLIB | IC50 | = | 9319.79 | nM | 5.03 |
| CHEMBL3349342 | — | IC50 | = | 9548.42 | nM | 5.02 |
| CHEMBL189584 | PD-173074 | IC50 | = | 12790.99 | nM | 4.89 |
| CHEMBL2363137 | — | IC50 | = | 13159.65 | nM | 4.88 |