Assay Detail
Functional
CHEMBL2363780
Review assay metadata, readout intent, target linkage, and publication context from the same page.
SANGER: Inhibition of human CAL-27 cell growth in a cell viability assay.
99
Total Activities
98
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CAL-27 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 99 | 5.69 | 9.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 9.77 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 9.47 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 8.86 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 8.70 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 8.68 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.49 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 7.49 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 7.48 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 7.45 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 7.38 |
| CHEMBL507361 | MIRDAMETINIB | 2.0 | 1 | 7.35 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 7.19 |
| CHEMBL585951 | — | — | 1 | 7.18 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 7.09 |
| CHEMBL217354 | — | — | 1 | 6.87 |
| CHEMBL1173655 | AFATINIB | 4.0 | 1 | 6.75 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 6.72 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 6.66 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 6.66 |
| CHEMBL939 | GEFITINIB | 4.0 | 1 | 6.54 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 6.46 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 6.36 |
| CHEMBL189963 | PALBOCICLIB | 4.0 | 1 | 6.31 |
| CHEMBL288441 | BOSUTINIB | 4.0 | 1 | 6.03 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.77 |
| CHEMBL803 | CYTARABINE | 4.0 | 1 | 5.71 |
| CHEMBL105442 | CI-1040 | 2.0 | 1 | 5.62 |
| CHEMBL289228 | TIPIFARNIB | 3.0 | 1 | 5.51 |
| CHEMBL1614701 | SELUMETINIB | 4.0 | 1 | 5.51 |
| CHEMBL2363137 | — | — | 1 | 5.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 0.1685 | nM | 9.77 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 0.3392 | nM | 9.47 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 1.387 | nM | 8.86 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 2.018 | nM | 8.70 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 2.086 | nM | 8.68 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 32.57 | nM | 7.49 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 32.04 | nM | 7.49 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 33.4 | nM | 7.48 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 35.16 | nM | 7.45 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 41.18 | nM | 7.38 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 44.91 | nM | 7.35 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 64.64 | nM | 7.19 |
| CHEMBL585951 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 81.56 | nM | 7.09 |
| CHEMBL217354 | — | IC50 | = | 135.79 | nM | 6.87 |
| CHEMBL1173655 | AFATINIB | IC50 | = | 176.36 | nM | 6.75 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 190.22 | nM | 6.72 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 221.17 | nM | 6.66 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 217.05 | nM | 6.66 |
| CHEMBL939 | GEFITINIB | IC50 | = | 289.08 | nM | 6.54 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 350.51 | nM | 6.46 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 436.96 | nM | 6.36 |
| CHEMBL189963 | PALBOCICLIB | IC50 | = | 494.59 | nM | 6.31 |
| CHEMBL288441 | BOSUTINIB | IC50 | = | 929.06 | nM | 6.03 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 1706.21 | nM | 5.77 |
| CHEMBL803 | CYTARABINE | IC50 | = | 1928.56 | nM | 5.71 |
| CHEMBL105442 | CI-1040 | IC50 | = | 2392.36 | nM | 5.62 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 3098.21 | nM | 5.51 |
| CHEMBL1614701 | SELUMETINIB | IC50 | = | 3061.18 | nM | 5.51 |
| CHEMBL2363137 | — | IC50 | = | 3156.98 | nM | 5.50 |
| CHEMBL1289926 | AXITINIB | IC50 | = | 4243.44 | nM | 5.37 |
| CHEMBL1190711 | — | IC50 | = | 4594.37 | nM | 5.34 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 4716.94 | nM | 5.33 |
| CHEMBL558642 | GSK-650394 | IC50 | = | 5332.21 | nM | 5.27 |
| CHEMBL1079175 | MK-2206 | IC50 | = | 5463.39 | nM | 5.26 |
| CHEMBL3349342 | — | IC50 | = | 5742.59 | nM | 5.24 |
| CHEMBL399530 | — | IC50 | = | 5955.7 | nM | 5.22 |
| CHEMBL11359 | CISPLATIN | IC50 | = | 6686.4 | nM | 5.17 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 8072.96 | nM | 5.09 |
| CHEMBL573107 | — | IC50 | = | 8127.2 | nM | 5.09 |
| CHEMBL258844 | — | IC50 | = | 8516.56 | nM | 5.07 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 9644.3 | nM | 5.02 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 10444.29 | nM | 4.98 |
| CHEMBL1084546 | PF-00562271 | IC50 | = | 12136.92 | nM | 4.92 |
| CHEMBL393929 | — | IC50 | = | 12163.66 | nM | 4.92 |
| CHEMBL221137 | EMBELIN | IC50 | = | 13102.37 | nM | 4.88 |
| CHEMBL2165191 | AZD-6482 | IC50 | = | 13503.35 | nM | 4.87 |
| CHEMBL188678 | — | IC50 | = | 14072.73 | nM | 4.85 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 15384.34 | nM | 4.81 |
| CHEMBL577784 | BX-795 | IC50 | = | 15389.77 | nM | 4.81 |