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Assay Detail

CHEMBL2363791

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Functional
SANGER: Inhibition of human TE-15 cell growth in a cell viability assay.
ChEMBL ↗
78
Total Activities
77
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type TE-15
Confidence 1 — Organism
Curated By Autocuration

Target

TE-15 (CHEMBL2366086) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute

· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 78 6.11 10.33

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL888 GEMCITABINE 4.0 1 10.33
CHEMBL94657 PATUPILONE 3.0 1 9.65
CHEMBL428647 PACLITAXEL 4.0 1 9.54
CHEMBL413 SIROLIMUS 4.0 1 8.87
CHEMBL553025 VINORELBINE 4.0 1 8.51
CHEMBL325041 BORTEZOMIB 3.0 1 8.46
CHEMBL96926 THAPSIGARGIN — 1 8.31
CHEMBL5416410 DASATINIB 4.0 1 8.23
CHEMBL514499 GW843682X — 1 7.96
CHEMBL252164 LUMINESPIB 2.0 1 7.87
CHEMBL53463 DOXORUBICIN 4.0 1 7.62
CHEMBL513909 BI-2536 2.0 1 7.56
CHEMBL300389 — — 1 7.40
CHEMBL1256459 TORIN1 — 1 7.35
CHEMBL379300 A-443654 — 1 7.23
CHEMBL105 MITOMYCIN 4.0 1 7.13
CHEMBL449158 BRYOSTATIN 1 2.0 1 6.96
CHEMBL2107358 OBATOCLAX MESYLATE 3.0 1 6.69
CHEMBL213100 — — 1 6.62
CHEMBL1171837 PONATINIB 4.0 1 6.58
CHEMBL217092 SARACATINIB 3.0 1 6.56
CHEMBL197603 — — 1 6.55
CHEMBL289228 TIPIFARNIB 3.0 1 6.44
CHEMBL585951 — — 1 6.42
CHEMBL9470 SHIKONIN — 1 6.40
CHEMBL535 SUNITINIB 4.0 1 6.29
CHEMBL509032 TAE-684 — 1 6.29
CHEMBL401930 — — 1 6.09
CHEMBL572878 TOZASERTIB 2.0 1 6.07
CHEMBL44657 ETOPOSIDE 4.0 1 6.02

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL888 GEMCITABINE IC50 = 0.04637 nM 10.33
CHEMBL94657 PATUPILONE IC50 = 0.2254 nM 9.65
CHEMBL428647 PACLITAXEL IC50 = 0.2869 nM 9.54
CHEMBL413 SIROLIMUS IC50 = 1.363 nM 8.87
CHEMBL553025 VINORELBINE IC50 = 3.103 nM 8.51
CHEMBL325041 BORTEZOMIB IC50 = 3.432 nM 8.46
CHEMBL96926 THAPSIGARGIN IC50 = 4.912 nM 8.31
CHEMBL5416410 DASATINIB IC50 = 5.891 nM 8.23
CHEMBL514499 GW843682X IC50 = 10.83 nM 7.96
CHEMBL252164 LUMINESPIB IC50 = 13.36 nM 7.87
CHEMBL53463 DOXORUBICIN IC50 = 24.14 nM 7.62
CHEMBL513909 BI-2536 IC50 = 27.38 nM 7.56
CHEMBL300389 — IC50 = 39.42 nM 7.40
CHEMBL1256459 TORIN1 IC50 = 44.35 nM 7.35
CHEMBL379300 A-443654 IC50 = 59.09 nM 7.23
CHEMBL105 MITOMYCIN IC50 = 73.7 nM 7.13
CHEMBL449158 BRYOSTATIN 1 IC50 = 109.18 nM 6.96
CHEMBL2107358 OBATOCLAX MESYLATE IC50 = 202.52 nM 6.69
CHEMBL213100 — IC50 = 242.76 nM 6.62
CHEMBL1171837 PONATINIB IC50 = 260.91 nM 6.58
CHEMBL217092 SARACATINIB IC50 = 274.12 nM 6.56
CHEMBL197603 — IC50 = 279.17 nM 6.55
CHEMBL289228 TIPIFARNIB IC50 = 364.62 nM 6.44
CHEMBL585951 — IC50 = 375.44 nM 6.42
CHEMBL9470 SHIKONIN IC50 = 400.31 nM 6.40
CHEMBL509032 TAE-684 IC50 = 511.24 nM 6.29
CHEMBL535 SUNITINIB IC50 = 507.61 nM 6.29
CHEMBL401930 — IC50 = 813.28 nM 6.09
CHEMBL572878 TOZASERTIB IC50 = 850.98 nM 6.07
CHEMBL575448 BMS-754807 IC50 = 955.56 nM 6.02
CHEMBL44657 ETOPOSIDE IC50 = 959.64 nM 6.02
CHEMBL392695 S-TRITYL-L-CYSTEINE IC50 = 1022.81 nM 5.99
CHEMBL1190711 — IC50 = 1282.42 nM 5.89
CHEMBL608533 MIDOSTAURIN IC50 = 1537.48 nM 5.81
CHEMBL515416 — IC50 = 1818.09 nM 5.74
CHEMBL1643959 — IC50 = 1847.96 nM 5.73
CHEMBL64925 MG-132 IC50 = 1923.73 nM 5.72
CHEMBL2363137 — IC50 = 2154.05 nM 5.67
CHEMBL191384 — IC50 = 2217.98 nM 5.65
CHEMBL558642 GSK-650394 IC50 = 2591.81 nM 5.59
CHEMBL6067492 BLEOMYCIN IC50 = 3223.15 nM 5.49
CHEMBL412142 LADUVIGLUSIB IC50 = 3953.43 nM 5.40
CHEMBL2165191 AZD-6482 IC50 = 4670.08 nM 5.33
CHEMBL1242367 — IC50 = 5118.13 nM 5.29
CHEMBL553 ERLOTINIB IC50 = 5472.7 nM 5.26
CHEMBL1084546 PF-00562271 IC50 = 5577.79 nM 5.25
CHEMBL1091644 LINSITINIB IC50 = 6066.05 nM 5.22
CHEMBL258844 — IC50 = 6493.93 nM 5.19
CHEMBL477772 PAZOPANIB IC50 = 7169.24 nM 5.14
CHEMBL221137 EMBELIN IC50 = 7244.51 nM 5.14