Assay Detail
Functional
CHEMBL2363792
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SANGER: Inhibition of human TE-441-T cell growth in a cell viability assay.
78
Total Activities
77
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | TE-441-T |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 78 | 5.38 | 8.65 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL9470 | SHIKONIN | — | 1 | 8.65 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 7.58 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 7.46 |
| CHEMBL300389 | — | — | 1 | 7.42 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 7.31 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 7.31 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.05 |
| CHEMBL585951 | — | — | 1 | 6.50 |
| CHEMBL513909 | BI-2536 | 2.0 | 1 | 6.30 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 6.28 |
| CHEMBL575448 | BMS-754807 | 2.0 | 1 | 6.25 |
| CHEMBL514499 | GW843682X | — | 1 | 6.24 |
| CHEMBL379300 | A-443654 | — | 1 | 6.10 |
| CHEMBL608533 | MIDOSTAURIN | 4.0 | 1 | 6.00 |
| CHEMBL1256459 | TORIN1 | — | 1 | 5.98 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 5.96 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 5.84 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 5.79 |
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 5.60 |
| CHEMBL2144069 | — | — | 1 | 5.55 |
| CHEMBL1171837 | PONATINIB | 4.0 | 1 | 5.43 |
| CHEMBL1084546 | PF-00562271 | 1.0 | 1 | 5.42 |
| CHEMBL1190711 | — | — | 1 | 5.40 |
| CHEMBL392695 | S-TRITYL-L-CYSTEINE | — | 1 | 5.32 |
| CHEMBL1091644 | LINSITINIB | 3.0 | 1 | 5.31 |
| CHEMBL413 | SIROLIMUS | 4.0 | 1 | 5.28 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 5.18 |
| CHEMBL2363137 | — | — | 1 | 5.14 |
| CHEMBL515416 | — | — | 1 | 5.02 |
| CHEMBL472940 | — | — | 1 | 4.94 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL9470 | SHIKONIN | IC50 | = | 2.238 | nM | 8.65 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 26.34 | nM | 7.58 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 34.86 | nM | 7.46 |
| CHEMBL300389 | — | IC50 | = | 38.43 | nM | 7.42 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 49.3 | nM | 7.31 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 48.81 | nM | 7.31 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 89.82 | nM | 7.05 |
| CHEMBL585951 | — | IC50 | = | 315.83 | nM | 6.50 |
| CHEMBL513909 | BI-2536 | IC50 | = | 501.2 | nM | 6.30 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 524.79 | nM | 6.28 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 563.55 | nM | 6.25 |
| CHEMBL514499 | GW843682X | IC50 | = | 570.51 | nM | 6.24 |
| CHEMBL379300 | A-443654 | IC50 | = | 797.81 | nM | 6.10 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 994.34 | nM | 6.00 |
| CHEMBL1256459 | TORIN1 | IC50 | = | 1043.5 | nM | 5.98 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 1109.01 | nM | 5.96 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 1428.17 | nM | 5.84 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 1602.76 | nM | 5.79 |
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 2521.7 | nM | 5.60 |
| CHEMBL2144069 | — | IC50 | = | 2806.68 | nM | 5.55 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 3730.28 | nM | 5.43 |
| CHEMBL1084546 | PF-00562271 | IC50 | = | 3829.3 | nM | 5.42 |
| CHEMBL1190711 | — | IC50 | = | 3956.73 | nM | 5.40 |
| CHEMBL392695 | S-TRITYL-L-CYSTEINE | IC50 | = | 4787.2 | nM | 5.32 |
| CHEMBL1091644 | LINSITINIB | IC50 | = | 4905.37 | nM | 5.31 |
| CHEMBL413 | SIROLIMUS | IC50 | = | 5278.2 | nM | 5.28 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 6550.1 | nM | 5.18 |
| CHEMBL2363137 | — | IC50 | = | 7312.56 | nM | 5.14 |
| CHEMBL515416 | — | IC50 | = | 9460.73 | nM | 5.02 |
| CHEMBL472940 | — | IC50 | = | 11545.58 | nM | 4.94 |
| CHEMBL941 | IMATINIB | IC50 | = | 17288.58 | nM | 4.76 |
| CHEMBL197603 | — | IC50 | = | 21760.73 | nM | 4.66 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 24615.32 | nM | 4.61 |
| CHEMBL2165191 | AZD-6482 | IC50 | = | 25218.76 | nM | 4.60 |
| CHEMBL554 | LAPATINIB | IC50 | = | 28788.96 | nM | 4.54 |
| CHEMBL259181 | — | IC50 | = | 29833.83 | nM | 4.53 |
| CHEMBL4298697 | — | IC50 | = | 30016.73 | nM | 4.52 |
| CHEMBL572878 | TOZASERTIB | IC50 | = | 34637.12 | nM | 4.46 |
| CHEMBL14762 | SELICICLIB | IC50 | = | 36114.81 | nM | 4.44 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 39144.74 | nM | 4.41 |
| CHEMBL64925 | MG-132 | IC50 | = | 40760.07 | nM | 4.39 |
| CHEMBL1673039 | — | IC50 | = | 42267.18 | nM | 4.37 |
| CHEMBL1643959 | — | IC50 | = | 42828.9 | nM | 4.37 |
| CHEMBL373751 | GSK-319347A | IC50 | = | 47893.41 | nM | 4.32 |
| CHEMBL601719 | CRIZOTINIB | IC50 | = | 53767.33 | nM | 4.27 |
| CHEMBL221137 | EMBELIN | IC50 | = | 64975.42 | nM | 4.19 |
| CHEMBL450786 | PHA-665752 | IC50 | = | 69249.3 | nM | 4.16 |
| CHEMBL409 | BICALUTAMIDE | IC50 | = | 69042.41 | nM | 4.16 |
| CHEMBL591429 | PAC-1 | IC50 | = | 81706.54 | nM | 4.09 |
| CHEMBL220241 | GSK-269962A | IC50 | = | 87247.6 | nM | 4.06 |