Assay Detail
Functional
CHEMBL2363794
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SANGER: Inhibition of human TE-6 cell growth in a cell viability assay.
139
Total Activities
137
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | TE-6 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 139 | 5.33 | 8.56 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL413 | SIROLIMUS | 4.0 | 1 | 8.56 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.24 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 7.94 |
| CHEMBL514499 | GW843682X | — | 1 | 7.75 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 7.75 |
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 7.70 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 7.64 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 7.25 |
| CHEMBL513909 | BI-2536 | 2.0 | 1 | 7.24 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 7.06 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 6.86 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 6.75 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 6.72 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 6.66 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 6.61 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 6.60 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 6.59 |
| CHEMBL1173655 | AFATINIB | 4.0 | 1 | 6.39 |
| CHEMBL300389 | — | — | 1 | 6.35 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.33 |
| CHEMBL1256459 | TORIN1 | — | 1 | 6.17 |
| CHEMBL939 | GEFITINIB | 4.0 | 1 | 6.12 |
| CHEMBL379300 | A-443654 | — | 1 | 6.07 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 6.05 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 5.99 |
| CHEMBL5416410 | DASATINIB | 4.0 | 1 | 5.92 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 5.87 |
| CHEMBL554 | LAPATINIB | 4.0 | 1 | 5.81 |
| CHEMBL608533 | MIDOSTAURIN | 4.0 | 1 | 5.78 |
| CHEMBL1801204 | AZD-8055 | 1.0 | 1 | 5.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL413 | SIROLIMUS | IC50 | = | 2.766 | nM | 8.56 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 5.703 | nM | 8.24 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 11.48 | nM | 7.94 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 17.82 | nM | 7.75 |
| CHEMBL514499 | GW843682X | IC50 | = | 17.93 | nM | 7.75 |
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 20.08 | nM | 7.70 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 22.99 | nM | 7.64 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 56.47 | nM | 7.25 |
| CHEMBL513909 | BI-2536 | IC50 | = | 57.22 | nM | 7.24 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 87.2 | nM | 7.06 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 139.0 | nM | 6.86 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 178.5 | nM | 6.75 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 188.9 | nM | 6.72 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 219.68 | nM | 6.66 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 246.12 | nM | 6.61 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 250.35 | nM | 6.60 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 257.5 | nM | 6.59 |
| CHEMBL1173655 | AFATINIB | IC50 | = | 402.46 | nM | 6.39 |
| CHEMBL300389 | — | IC50 | = | 449.17 | nM | 6.35 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 469.81 | nM | 6.33 |
| CHEMBL1256459 | TORIN1 | IC50 | = | 681.04 | nM | 6.17 |
| CHEMBL939 | GEFITINIB | IC50 | = | 764.31 | nM | 6.12 |
| CHEMBL379300 | A-443654 | IC50 | = | 860.22 | nM | 6.07 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 893.67 | nM | 6.05 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 1035.66 | nM | 5.99 |
| CHEMBL5416410 | DASATINIB | IC50 | = | 1212.26 | nM | 5.92 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 1352.8 | nM | 5.87 |
| CHEMBL554 | LAPATINIB | IC50 | = | 1552.01 | nM | 5.81 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 1648.33 | nM | 5.78 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 1708.74 | nM | 5.77 |
| CHEMBL585951 | — | IC50 | = | 2004.38 | nM | 5.70 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 2144.72 | nM | 5.67 |
| CHEMBL509032 | TAE-684 | IC50 | = | 2190.5 | nM | 5.66 |
| CHEMBL553 | ERLOTINIB | IC50 | = | 2567.8 | nM | 5.59 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 2967.91 | nM | 5.53 |
| CHEMBL392695 | S-TRITYL-L-CYSTEINE | IC50 | = | 3900.22 | nM | 5.41 |
| CHEMBL64925 | MG-132 | IC50 | = | 3945.61 | nM | 5.40 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 4817.03 | nM | 5.32 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 4939.77 | nM | 5.31 |
| CHEMBL521851 | PICTILISIB | IC50 | = | 5418.16 | nM | 5.27 |
| CHEMBL1084546 | PF-00562271 | IC50 | = | 5445.69 | nM | 5.26 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 5741.82 | nM | 5.24 |
| CHEMBL1090771 | AVAGACESTAT | IC50 | = | 6190.82 | nM | 5.21 |
| CHEMBL1079175 | MK-2206 | IC50 | = | 6930.38 | nM | 5.16 |
| CHEMBL1190711 | — | IC50 | = | 6971.83 | nM | 5.16 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 7206.09 | nM | 5.14 |
| CHEMBL189963 | PALBOCICLIB | IC50 | = | 7206.01 | nM | 5.14 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 7449.08 | nM | 5.13 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 7558.81 | nM | 5.12 |
| CHEMBL573107 | — | IC50 | = | 8237.88 | nM | 5.08 |