Assay Detail
Functional
CHEMBL2363795
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SANGER: Inhibition of human TE-8 cell growth in a cell viability assay.
139
Total Activities
137
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | TE-8 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 139 | 5.91 | 9.95 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 9.95 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 9.44 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.93 |
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 8.92 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 8.86 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 8.62 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 8.38 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 8.27 |
| CHEMBL514499 | GW843682X | — | 1 | 8.23 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 8.21 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 8.12 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 8.10 |
| CHEMBL513909 | BI-2536 | 2.0 | 1 | 8.03 |
| CHEMBL5416410 | DASATINIB | 4.0 | 1 | 7.80 |
| CHEMBL300389 | — | — | 1 | 7.62 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 7.45 |
| CHEMBL575448 | BMS-754807 | 2.0 | 1 | 7.44 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 7.34 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 7.18 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 7.11 |
| CHEMBL1256459 | TORIN1 | — | 1 | 7.04 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 7.00 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 6.95 |
| CHEMBL217354 | — | — | 1 | 6.89 |
| CHEMBL379300 | A-443654 | — | 1 | 6.86 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 6.70 |
| CHEMBL803 | CYTARABINE | 4.0 | 1 | 6.66 |
| CHEMBL197603 | — | — | 1 | 6.62 |
| CHEMBL213100 | — | — | 1 | 6.62 |
| CHEMBL507361 | MIRDAMETINIB | 2.0 | 1 | 6.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL94657 | PATUPILONE | IC50 | = | 0.1111 | nM | 9.95 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 0.3655 | nM | 9.44 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 1.174 | nM | 8.93 |
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 1.19 | nM | 8.92 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 1.37 | nM | 8.86 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 2.369 | nM | 8.62 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 4.17 | nM | 8.38 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 5.405 | nM | 8.27 |
| CHEMBL514499 | GW843682X | IC50 | = | 5.89 | nM | 8.23 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 6.156 | nM | 8.21 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 7.503 | nM | 8.12 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 8.001 | nM | 8.10 |
| CHEMBL513909 | BI-2536 | IC50 | = | 9.41 | nM | 8.03 |
| CHEMBL5416410 | DASATINIB | IC50 | = | 15.76 | nM | 7.80 |
| CHEMBL300389 | — | IC50 | = | 23.75 | nM | 7.62 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 35.86 | nM | 7.45 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 36.54 | nM | 7.44 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 45.98 | nM | 7.34 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 66.52 | nM | 7.18 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 77.77 | nM | 7.11 |
| CHEMBL1256459 | TORIN1 | IC50 | = | 90.16 | nM | 7.04 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 98.85 | nM | 7.00 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 112.64 | nM | 6.95 |
| CHEMBL217354 | — | IC50 | = | 129.26 | nM | 6.89 |
| CHEMBL379300 | A-443654 | IC50 | = | 137.48 | nM | 6.86 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 200.19 | nM | 6.70 |
| CHEMBL803 | CYTARABINE | IC50 | = | 219.1 | nM | 6.66 |
| CHEMBL197603 | — | IC50 | = | 242.46 | nM | 6.62 |
| CHEMBL213100 | — | IC50 | = | 239.24 | nM | 6.62 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 255.75 | nM | 6.59 |
| CHEMBL64925 | MG-132 | IC50 | = | 270.09 | nM | 6.57 |
| CHEMBL64925 | MG-132 | IC50 | = | 342.79 | nM | 6.46 |
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 369.35 | nM | 6.43 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 376.69 | nM | 6.42 |
| CHEMBL509032 | TAE-684 | IC50 | = | 428.8 | nM | 6.37 |
| CHEMBL401930 | — | IC50 | = | 506.19 | nM | 6.30 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 667.19 | nM | 6.18 |
| CHEMBL392695 | S-TRITYL-L-CYSTEINE | IC50 | = | 721.8 | nM | 6.14 |
| CHEMBL585951 | — | IC50 | = | 831.36 | nM | 6.08 |
| CHEMBL217092 | SARACATINIB | IC50 | = | 872.75 | nM | 6.06 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 928.47 | nM | 6.03 |
| CHEMBL3349342 | — | IC50 | = | 1120.35 | nM | 5.95 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 1122.91 | nM | 5.95 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 1280.63 | nM | 5.89 |
| CHEMBL1091644 | LINSITINIB | IC50 | = | 1314.62 | nM | 5.88 |
| CHEMBL189963 | PALBOCICLIB | IC50 | = | 1417.74 | nM | 5.85 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 1455.6 | nM | 5.84 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 1679.0 | nM | 5.78 |
| CHEMBL572878 | TOZASERTIB | IC50 | = | 1803.68 | nM | 5.74 |
| CHEMBL1173655 | AFATINIB | IC50 | = | 1913.77 | nM | 5.72 |