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Assay Detail

CHEMBL2363796

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Functional
SANGER: Inhibition of human TE-9 cell growth in a cell viability assay.
ChEMBL ↗
139
Total Activities
137
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type TE-9
Confidence 1 — Organism
Curated By Autocuration

Target

TE-9 (CHEMBL2366147) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute

· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 139 5.58 9.74

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL325041 BORTEZOMIB 3.0 1 9.74
CHEMBL3545252 DOCETAXEL 4.0 1 9.17
CHEMBL553025 VINORELBINE 4.0 1 8.97
CHEMBL94657 PATUPILONE 3.0 1 8.80
CHEMBL428647 PACLITAXEL 4.0 1 8.49
CHEMBL159 VINBLASTINE 4.0 1 8.37
CHEMBL96926 THAPSIGARGIN — 1 7.88
CHEMBL514499 GW843682X — 1 7.67
CHEMBL513909 BI-2536 2.0 1 7.65
CHEMBL65 CAMPTOTHECIN -1.0 1 7.63
CHEMBL252164 LUMINESPIB 2.0 1 7.37
CHEMBL44657 ETOPOSIDE 4.0 1 7.25
CHEMBL585951 — — 1 7.16
CHEMBL1972860 ELESCLOMOL 3.0 1 6.93
CHEMBL449158 BRYOSTATIN 1 2.0 1 6.78
CHEMBL888 GEMCITABINE 4.0 1 6.72
CHEMBL109480 TANESPIMYCIN 3.0 1 6.66
CHEMBL217354 — — 1 6.65
CHEMBL2107358 OBATOCLAX MESYLATE 3.0 1 6.63
CHEMBL53463 DOXORUBICIN 4.0 1 6.59
CHEMBL1256459 TORIN1 — 1 6.54
CHEMBL379300 A-443654 — 1 6.41
CHEMBL9470 SHIKONIN — 1 6.39
CHEMBL603469 LESTAURTINIB 3.0 1 6.38
CHEMBL105 MITOMYCIN 4.0 1 6.30
CHEMBL64925 MG-132 — 2 6.21
CHEMBL554 LAPATINIB 4.0 1 6.13
CHEMBL5416410 DASATINIB 4.0 1 6.06
CHEMBL392695 S-TRITYL-L-CYSTEINE — 1 6.04
CHEMBL509032 TAE-684 — 1 5.95

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL325041 BORTEZOMIB IC50 = 0.1823 nM 9.74
CHEMBL3545252 DOCETAXEL IC50 = 0.6756 nM 9.17
CHEMBL553025 VINORELBINE IC50 = 1.078 nM 8.97
CHEMBL94657 PATUPILONE IC50 = 1.568 nM 8.80
CHEMBL428647 PACLITAXEL IC50 = 3.255 nM 8.49
CHEMBL159 VINBLASTINE IC50 = 4.27 nM 8.37
CHEMBL96926 THAPSIGARGIN IC50 = 13.26 nM 7.88
CHEMBL514499 GW843682X IC50 = 21.29 nM 7.67
CHEMBL513909 BI-2536 IC50 = 22.61 nM 7.65
CHEMBL65 CAMPTOTHECIN IC50 = 23.65 nM 7.63
CHEMBL252164 LUMINESPIB IC50 = 42.37 nM 7.37
CHEMBL44657 ETOPOSIDE IC50 = 55.93 nM 7.25
CHEMBL585951 — IC50 = 69.16 nM 7.16
CHEMBL1972860 ELESCLOMOL IC50 = 117.35 nM 6.93
CHEMBL449158 BRYOSTATIN 1 IC50 = 166.88 nM 6.78
CHEMBL888 GEMCITABINE IC50 = 189.63 nM 6.72
CHEMBL109480 TANESPIMYCIN IC50 = 217.86 nM 6.66
CHEMBL217354 — IC50 = 224.85 nM 6.65
CHEMBL2107358 OBATOCLAX MESYLATE IC50 = 233.2 nM 6.63
CHEMBL53463 DOXORUBICIN IC50 = 257.47 nM 6.59
CHEMBL1256459 TORIN1 IC50 = 289.85 nM 6.54
CHEMBL379300 A-443654 IC50 = 388.97 nM 6.41
CHEMBL9470 SHIKONIN IC50 = 407.52 nM 6.39
CHEMBL603469 LESTAURTINIB IC50 = 414.57 nM 6.38
CHEMBL105 MITOMYCIN IC50 = 500.49 nM 6.30
CHEMBL64925 MG-132 IC50 = 610.33 nM 6.21
CHEMBL554 LAPATINIB IC50 = 744.53 nM 6.13
CHEMBL5416410 DASATINIB IC50 = 875.32 nM 6.06
CHEMBL392695 S-TRITYL-L-CYSTEINE IC50 = 915.17 nM 6.04
CHEMBL509032 TAE-684 IC50 = 1113.28 nM 5.95
CHEMBL1879463 DACTOLISIB IC50 = 1129.73 nM 5.95
CHEMBL553 ERLOTINIB IC50 = 1225.11 nM 5.91
CHEMBL575448 BMS-754807 IC50 = 1477.86 nM 5.83
CHEMBL2041933 AZD-7762 IC50 = 1634.56 nM 5.79
CHEMBL300389 — IC50 = 1729.83 nM 5.76
CHEMBL803 CYTARABINE IC50 = 1787.54 nM 5.75
CHEMBL27759 ENTINOSTAT IC50 = 1844.22 nM 5.73
CHEMBL573107 — IC50 = 2173.76 nM 5.66
CHEMBL401930 — IC50 = 2502.79 nM 5.60
CHEMBL2363137 — IC50 = 2685.61 nM 5.57
CHEMBL572878 TOZASERTIB IC50 = 3267.36 nM 5.49
CHEMBL34259 METHOTREXATE IC50 = 3470.42 nM 5.46
CHEMBL1173655 AFATINIB IC50 = 3843.82 nM 5.42
CHEMBL512504 — IC50 = 3996.19 nM 5.40
CHEMBL413 SIROLIMUS IC50 = 4175.82 nM 5.38
CHEMBL213100 — IC50 = 4391.83 nM 5.36
CHEMBL202721 — IC50 = 4615.02 nM 5.34
CHEMBL939 GEFITINIB IC50 = 5015.25 nM 5.30
CHEMBL507361 MIRDAMETINIB IC50 = 5384.9 nM 5.27
CHEMBL1084546 PF-00562271 IC50 = 5617.88 nM 5.25