Assay Detail
Functional
CHEMBL2363839
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SANGER: Inhibition of human CGTH-W-1 cell growth in a cell viability assay.
139
Total Activities
137
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CGTH-W-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 139 | 6.01 | 10.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 10.68 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 9.63 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 9.27 |
| CHEMBL1171837 | PONATINIB | 4.0 | 1 | 8.77 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 8.56 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 8.55 |
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 8.51 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 8.48 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 8.26 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 8.24 |
| CHEMBL1289926 | AXITINIB | 4.0 | 1 | 8.14 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 7.96 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 7.85 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 7.69 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 7.63 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 7.63 |
| CHEMBL535 | SUNITINIB | 4.0 | 1 | 7.51 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 7.51 |
| CHEMBL5416410 | DASATINIB | 4.0 | 1 | 7.45 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 7.41 |
| CHEMBL477772 | PAZOPANIB | 4.0 | 1 | 7.40 |
| CHEMBL608533 | MIDOSTAURIN | 4.0 | 1 | 7.37 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 7.36 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.27 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 7.26 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 7.24 |
| CHEMBL300389 | — | — | 1 | 7.10 |
| CHEMBL585951 | — | — | 1 | 7.08 |
| CHEMBL2144069 | — | — | 1 | 6.92 |
| CHEMBL803 | CYTARABINE | 4.0 | 1 | 6.74 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 0.02088 | nM | 10.68 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 0.2316 | nM | 9.63 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 0.5421 | nM | 9.27 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 1.686 | nM | 8.77 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 2.723 | nM | 8.56 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 2.803 | nM | 8.55 |
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 3.101 | nM | 8.51 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 3.275 | nM | 8.48 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 5.556 | nM | 8.26 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 5.755 | nM | 8.24 |
| CHEMBL1289926 | AXITINIB | IC50 | = | 7.223 | nM | 8.14 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 10.95 | nM | 7.96 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 14.2 | nM | 7.85 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 20.63 | nM | 7.69 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 23.28 | nM | 7.63 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 23.49 | nM | 7.63 |
| CHEMBL535 | SUNITINIB | IC50 | = | 30.94 | nM | 7.51 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 31.21 | nM | 7.51 |
| CHEMBL5416410 | DASATINIB | IC50 | = | 35.48 | nM | 7.45 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 38.74 | nM | 7.41 |
| CHEMBL477772 | PAZOPANIB | IC50 | = | 40.01 | nM | 7.40 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 42.65 | nM | 7.37 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 43.57 | nM | 7.36 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 53.46 | nM | 7.27 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 54.49 | nM | 7.26 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 57.41 | nM | 7.24 |
| CHEMBL300389 | — | IC50 | = | 79.76 | nM | 7.10 |
| CHEMBL585951 | — | IC50 | = | 82.46 | nM | 7.08 |
| CHEMBL2144069 | — | IC50 | = | 121.3 | nM | 6.92 |
| CHEMBL803 | CYTARABINE | IC50 | = | 181.8 | nM | 6.74 |
| CHEMBL217354 | — | IC50 | = | 185.98 | nM | 6.73 |
| CHEMBL1256459 | TORIN1 | IC50 | = | 184.36 | nM | 6.73 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 241.5 | nM | 6.62 |
| CHEMBL379300 | A-443654 | IC50 | = | 245.66 | nM | 6.61 |
| CHEMBL1336 | SORAFENIB | IC50 | = | 250.22 | nM | 6.60 |
| CHEMBL941 | IMATINIB | IC50 | = | 383.74 | nM | 6.42 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 399.13 | nM | 6.40 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 499.93 | nM | 6.30 |
| CHEMBL513909 | BI-2536 | IC50 | = | 607.55 | nM | 6.22 |
| CHEMBL255863 | NILOTINIB | IC50 | = | 648.7 | nM | 6.19 |
| CHEMBL572881 | MOTESANIB | IC50 | = | 669.97 | nM | 6.17 |
| CHEMBL413 | SIROLIMUS | IC50 | = | 948.13 | nM | 6.02 |
| CHEMBL577784 | BX-795 | IC50 | = | 971.16 | nM | 6.01 |
| CHEMBL189963 | PALBOCICLIB | IC50 | = | 1171.86 | nM | 5.93 |
| CHEMBL135561 | — | IC50 | = | 1330.51 | nM | 5.88 |
| CHEMBL514499 | GW843682X | IC50 | = | 1467.92 | nM | 5.83 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 1558.19 | nM | 5.81 |
| CHEMBL1084546 | PF-00562271 | IC50 | = | 1616.79 | nM | 5.79 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 1899.46 | nM | 5.72 |
| CHEMBL558642 | GSK-650394 | IC50 | = | 2096.42 | nM | 5.68 |