Assay Detail
Functional
CHEMBL2377957
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Antiproliferative activity against HDFa cells after 30 hrs by [3H]-thymidine incorporation assay
8
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HDFa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Pyridinylquinazolines selectively inhibit human methionine aminopeptidase-1 in cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 5.76 | 6.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL327579 | — | — | 2 | 6.19 |
| CHEMBL2375627 | — | — | 1 | 6.12 |
| CHEMBL2375628 | — | — | 1 | 5.72 |
| CHEMBL2375624 | — | — | 1 | 5.72 |
| CHEMBL472879 | — | — | 1 | 5.44 |
| CHEMBL39879 | DIPYRIDYL | — | 1 | 5.00 |
| CHEMBL625 | THIABENDAZOLE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL327579 | — | EC50 | = | 650.0 | nM | 6.19 |
| CHEMBL2375627 | — | EC50 | = | 760.0 | nM | 6.12 |
| CHEMBL327579 | — | EC50 | = | 790.0 | nM | 6.10 |
| CHEMBL2375628 | — | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL2375624 | — | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL472879 | — | EC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL39879 | DIPYRIDYL | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL625 | THIABENDAZOLE | EC50 | > | 250000.0 | nM | - |