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Assay Detail

CHEMBL2378021

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human LS174 cells assessed as decrease in cell survival after 72 hrs by MTT assay
ChEMBL ↗
36
Total Activities
12
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type LS174
Confidence 1 — Organism
Curated By Autocuration

Target

NON-PROTEIN TARGET (CHEMBL3879801) ↗
Type NON-MOLECULAR

Publication

Phenylpropiophenone derivatives as potential anticancer agents: synthesis, biological evaluation and quantitative structure-activity relationship study.
Ivković BM, Nikolic K, Ilić BB, Žižak ŽS, Novaković RB, Čudina OA, Vladimirov SM.
Eur J Med Chem (2013) 63 : 239 -255
PubMed 23501110 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 24 4.57 4.95
Activity 12 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2375427 — — 3 4.95
CHEMBL2375419 — — 3 4.76
CHEMBL2375422 — — 3 4.73
CHEMBL2375425 — — 3 4.69
CHEMBL2375426 — — 3 4.68
CHEMBL2375424 — — 3 4.63
CHEMBL2375418 — — 3 4.58
CHEMBL2375421 — — 3 4.49
CHEMBL1963387 — — 3 4.45
CHEMBL476598 — — 3 4.38
CHEMBL2375420 — — 3 4.31
CHEMBL2375423 — — 3 4.14

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2375427 — IC50 = 11200.0 nM 4.95
CHEMBL2375427 — IC50 = 11200.05 nM 4.95
CHEMBL2375419 — IC50 = 17400.03 nM 4.76
CHEMBL2375419 — IC50 = 17400.0 nM 4.76
CHEMBL2375422 — IC50 = 18599.87 nM 4.73
CHEMBL2375422 — IC50 = 18600.0 nM 4.73
CHEMBL2375425 — IC50 = 20300.19 nM 4.69
CHEMBL2375425 — IC50 = 20300.0 nM 4.69
CHEMBL2375426 — IC50 = 20799.84 nM 4.68
CHEMBL2375426 — IC50 = 20800.0 nM 4.68
CHEMBL2375424 — IC50 = 23200.11 nM 4.63
CHEMBL2375424 — IC50 = 23200.0 nM 4.63
CHEMBL2375418 — IC50 = 26400.0 nM 4.58
CHEMBL2375418 — IC50 = 26399.76 nM 4.58
CHEMBL2375421 — IC50 = 32200.0 nM 4.49
CHEMBL2375421 — IC50 = 32200.31 nM 4.49
CHEMBL1963387 — IC50 = 35300.0 nM 4.45
CHEMBL1963387 — IC50 = 35299.62 nM 4.45
CHEMBL476598 — IC50 = 41200.26 nM 4.38
CHEMBL476598 — IC50 = 41200.0 nM 4.38
CHEMBL2375420 — IC50 = 48800.02 nM 4.31
CHEMBL2375420 — IC50 = 48800.0 nM 4.31
CHEMBL2375423 — IC50 = 72200.0 nM 4.14
CHEMBL2375423 — IC50 = 72200.47 nM 4.14
CHEMBL2375427 — Activity - — -
CHEMBL2375426 — Activity - — -
CHEMBL2375425 — Activity - — -
CHEMBL2375424 — Activity - — -
CHEMBL2375423 — Activity - — -
CHEMBL2375422 — Activity - — -
CHEMBL2375421 — Activity - — -
CHEMBL476598 — Activity - — -
CHEMBL2375420 — Activity - — -
CHEMBL1963387 — Activity - — -
CHEMBL2375419 — Activity - — -
CHEMBL2375418 — Activity - — -