Assay Detail
Binding
CHEMBL2378091
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Inhibition of 11beta-HSD1 in human HEK293 cells
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
11-beta-hydroxysteroid dehydrogenase 1 (CHEMBL4235) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
N-(Pyridin-2-yl) arylsulfonamide inhibitors of 11β-hydroxysteroid dehydrogenase type 1: strategies to eliminate reactive metabolites.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 19 | 7.09 | 10.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2377209 | — | — | 1 | 10.52 |
| CHEMBL495841 | — | — | 1 | 8.30 |
| CHEMBL489857 | — | — | 1 | 8.00 |
| CHEMBL2377205 | — | — | 1 | 7.68 |
| CHEMBL2377211 | — | — | 1 | 7.31 |
| CHEMBL2377216 | — | — | 1 | 7.29 |
| CHEMBL526098 | — | — | 1 | 7.28 |
| CHEMBL2377212 | — | — | 1 | 7.24 |
| CHEMBL2377210 | — | — | 1 | 7.14 |
| CHEMBL2377214 | — | — | 1 | 6.74 |
| CHEMBL2377208 | — | — | 1 | 6.71 |
| CHEMBL2377206 | — | — | 1 | 6.67 |
| CHEMBL2377213 | — | — | 1 | 6.49 |
| CHEMBL2377218 | — | — | 1 | 6.37 |
| CHEMBL2377219 | — | — | 1 | 6.22 |
| CHEMBL2377217 | — | — | 1 | 6.03 |
| CHEMBL2377215 | — | — | 1 | 5.93 |
| CHEMBL2377207 | — | — | 1 | 5.70 |
| CHEMBL2377204 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2377209 | — | EC50 | = | 0.03 | nM | 10.52 |
| CHEMBL495841 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL489857 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL2377205 | — | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL2377211 | — | EC50 | = | 49.0 | nM | 7.31 |
| CHEMBL2377216 | — | EC50 | = | 51.0 | nM | 7.29 |
| CHEMBL526098 | — | EC50 | = | 53.0 | nM | 7.28 |
| CHEMBL2377212 | — | EC50 | = | 58.0 | nM | 7.24 |
| CHEMBL2377210 | — | EC50 | = | 72.0 | nM | 7.14 |
| CHEMBL2377214 | — | EC50 | = | 184.0 | nM | 6.74 |
| CHEMBL2377208 | — | EC50 | = | 194.0 | nM | 6.71 |
| CHEMBL2377206 | — | EC50 | = | 213.0 | nM | 6.67 |
| CHEMBL2377213 | — | EC50 | = | 327.0 | nM | 6.49 |
| CHEMBL2377218 | — | EC50 | = | 423.0 | nM | 6.37 |
| CHEMBL2377219 | — | EC50 | = | 604.0 | nM | 6.22 |
| CHEMBL2377217 | — | EC50 | = | 936.0 | nM | 6.03 |
| CHEMBL2377215 | — | EC50 | = | 1161.0 | nM | 5.93 |
| CHEMBL2377207 | — | EC50 | = | 1980.0 | nM | 5.70 |
| CHEMBL2377204 | — | EC50 | > | 10000.0 | nM | - |