Compound Detail
CHEMBL2377210
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL2377210 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | YRGNSWPETKWGFR-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
386.4
MW (Da)
3.97
ALogP
5
HBA
1
HBD
95.7
PSA (Ų)
0.57
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 7.14
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 11-beta-hydroxysteroid dehydrogenase 1 CHEMBL4235 | EC50 | 7.14 | 7.14 | 72.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 11-beta-hydroxysteroid dehydrogenase 1 | EC50 | = | 72.0 | nM | 7.14 | Inhibition of 11beta-HSD1 in human HEK293 cells | 23489629 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 23489629 | 10.1016/j.bmcl.2013.02.066 | Liver microsomes | 1 |
| 23489629 | 10.1016/j.bmcl.2013.02.066 | 11-beta-hydroxysteroid dehydrogenase 1 | 1 |
Data from ChEMBL 36 via Core Engine