Assay Detail
Binding
CHEMBL2378713
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Inhibition of human methionine aminopeptidase 1 in presence of Co2+
32
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Pyridinylquinazolines selectively inhibit human methionine aminopeptidase-1 in cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 32 | 6.49 | 7.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1329554 | — | — | 1 | 7.31 |
| CHEMBL2375615 | — | — | 1 | 7.14 |
| CHEMBL2375622 | — | — | 1 | 7.09 |
| CHEMBL2375609 | — | — | 1 | 7.03 |
| CHEMBL2375620 | — | — | 1 | 7.03 |
| CHEMBL2375616 | — | — | 1 | 7.03 |
| CHEMBL2375624 | — | — | 1 | 7.00 |
| CHEMBL2375621 | — | — | 1 | 6.96 |
| CHEMBL2375613 | — | — | 1 | 6.96 |
| CHEMBL2375610 | — | — | 1 | 6.92 |
| CHEMBL2375612 | — | — | 1 | 6.92 |
| CHEMBL2375618 | — | — | 1 | 6.75 |
| CHEMBL472879 | — | — | 1 | 6.72 |
| CHEMBL2375608 | — | — | 1 | 6.60 |
| CHEMBL2375628 | — | — | 1 | 6.55 |
| CHEMBL39879 | DIPYRIDYL | — | 1 | 6.50 |
| CHEMBL327579 | — | — | 2 | 6.46 |
| CHEMBL2375614 | — | — | 1 | 6.41 |
| CHEMBL2375607 | — | — | 1 | 6.41 |
| CHEMBL45721 | — | — | 1 | 6.39 |
| CHEMBL2375627 | — | — | 1 | 6.37 |
| CHEMBL2375623 | — | — | 1 | 6.23 |
| CHEMBL2375625 | — | — | 1 | 6.07 |
| CHEMBL49678 | — | — | 1 | 6.06 |
| CHEMBL2375617 | — | — | 1 | 6.05 |
| CHEMBL1518085 | — | — | 1 | 6.03 |
| CHEMBL2375626 | — | — | 1 | 5.85 |
| CHEMBL2375629 | — | — | 1 | 5.82 |
| CHEMBL2375611 | — | — | 1 | 5.80 |
| CHEMBL625 | THIABENDAZOLE | 4.0 | 1 | 5.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1329554 | — | EC50 | = | 49.0 | nM | 7.31 |
| CHEMBL2375615 | — | EC50 | = | 73.0 | nM | 7.14 |
| CHEMBL2375622 | — | EC50 | = | 81.0 | nM | 7.09 |
| CHEMBL2375609 | — | EC50 | = | 93.0 | nM | 7.03 |
| CHEMBL2375620 | — | EC50 | = | 94.0 | nM | 7.03 |
| CHEMBL2375616 | — | EC50 | = | 94.0 | nM | 7.03 |
| CHEMBL2375624 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL2375621 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL2375613 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL2375610 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL2375612 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL2375618 | — | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL472879 | — | EC50 | = | 190.0 | nM | 6.72 |
| CHEMBL2375608 | — | EC50 | = | 250.0 | nM | 6.60 |
| CHEMBL2375628 | — | EC50 | = | 280.0 | nM | 6.55 |
| CHEMBL39879 | DIPYRIDYL | EC50 | = | 320.0 | nM | 6.50 |
| CHEMBL327579 | — | EC50 | = | 350.0 | nM | 6.46 |
| CHEMBL327579 | — | EC50 | = | 360.0 | nM | 6.44 |
| CHEMBL2375614 | — | EC50 | = | 390.0 | nM | 6.41 |
| CHEMBL2375607 | — | EC50 | = | 390.0 | nM | 6.41 |
| CHEMBL45721 | — | EC50 | = | 410.0 | nM | 6.39 |
| CHEMBL2375627 | — | EC50 | = | 430.0 | nM | 6.37 |
| CHEMBL2375623 | — | EC50 | = | 590.0 | nM | 6.23 |
| CHEMBL2375625 | — | EC50 | = | 850.0 | nM | 6.07 |
| CHEMBL49678 | — | EC50 | = | 870.0 | nM | 6.06 |
| CHEMBL2375617 | — | EC50 | = | 900.0 | nM | 6.05 |
| CHEMBL1518085 | — | EC50 | = | 940.0 | nM | 6.03 |
| CHEMBL2375626 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL2375629 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL2375611 | — | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL625 | THIABENDAZOLE | EC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL2375619 | — | EC50 | = | 6000.0 | nM | 5.22 |