Compound Detail
CHEMBL2375608
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Basic Information
| ChEMBL ID | CHEMBL2375608 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VERDULHGTFVKHY-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
444.6
MW (Da)
4.12
ALogP
5
HBA
0
HBD
66.4
PSA (Ų)
0.47
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 6.6
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Methionine aminopeptidase 1 CHEMBL2474 | EC50 | 6.6 | 5.85 | 250.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Methionine aminopeptidase 1 | EC50 | = | 250.0 | nM | 6.6 | Inhibition of human methionine aminopeptidase 1 in presence of Co2+ | 23634668 |
| Methionine aminopeptidase 1 | EC50 | = | 8000.0 | nM | 5.1 | Inhibition of human methionine aminopeptidase 1 in presence of Mn2+ | 23634668 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 23634668 | 10.1021/jm400227z | Methionine aminopeptidase 1 | 2 |
| 23634668 | 10.1021/jm400227z | Methionine aminopeptidase 2 | 1 |
Data from ChEMBL 36 via Core Engine