Assay Detail
Binding
CHEMBL2378715
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Inhibition of human methionine aminopeptidase 1 in presence of Mn2+
32
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Pyridinylquinazolines selectively inhibit human methionine aminopeptidase-1 in cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 32 | 5.07 | 5.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2375609 | — | — | 1 | 5.47 |
| CHEMBL2375621 | — | — | 1 | 5.43 |
| CHEMBL2375610 | — | — | 1 | 5.32 |
| CHEMBL2375622 | — | — | 1 | 5.32 |
| CHEMBL2375607 | — | — | 1 | 5.30 |
| CHEMBL2375624 | — | — | 1 | 5.29 |
| CHEMBL2375612 | — | — | 1 | 5.28 |
| CHEMBL2375613 | — | — | 1 | 5.12 |
| CHEMBL2375608 | — | — | 1 | 5.10 |
| CHEMBL2375620 | — | — | 1 | 5.09 |
| CHEMBL2375615 | — | — | 1 | 5.08 |
| CHEMBL2375618 | — | — | 1 | 4.96 |
| CHEMBL472879 | — | — | 1 | 4.82 |
| CHEMBL2375616 | — | — | 1 | 4.82 |
| CHEMBL2375623 | — | — | 1 | 4.77 |
| CHEMBL1518085 | — | — | 1 | 4.62 |
| CHEMBL1329554 | — | — | 1 | 4.39 |
| CHEMBL39879 | DIPYRIDYL | — | 1 | - |
| CHEMBL327579 | — | — | 2 | - |
| CHEMBL2375627 | — | — | 1 | - |
| CHEMBL2375626 | — | — | 1 | - |
| CHEMBL2375625 | — | — | 1 | - |
| CHEMBL2375628 | — | — | 1 | - |
| CHEMBL2375629 | — | — | 1 | - |
| CHEMBL2375611 | — | — | 1 | - |
| CHEMBL2375619 | — | — | 1 | - |
| CHEMBL2375617 | — | — | 1 | - |
| CHEMBL625 | THIABENDAZOLE | 4.0 | 1 | - |
| CHEMBL49678 | — | — | 1 | - |
| CHEMBL45721 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2375609 | — | EC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL2375621 | — | EC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL2375610 | — | EC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL2375622 | — | EC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL2375607 | — | EC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL2375624 | — | EC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL2375612 | — | EC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL2375613 | — | EC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL2375608 | — | EC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL2375620 | — | EC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL2375615 | — | EC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL2375618 | — | EC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL2375616 | — | EC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL472879 | — | EC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL2375623 | — | EC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL1518085 | — | EC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL1329554 | — | EC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL2375626 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL2375625 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL625 | THIABENDAZOLE | EC50 | > | 100000.0 | nM | - |
| CHEMBL327579 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL2375619 | — | EC50 | > | 400000.0 | nM | - |
| CHEMBL2375617 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL49678 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL45721 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL2375614 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL2375611 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL2375629 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL2375628 | — | EC50 | > | 200000.0 | nM | - |
| CHEMBL2375627 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL327579 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL39879 | DIPYRIDYL | EC50 | > | 100000.0 | nM | - |