Assay Detail
Binding
CHEMBL2378751
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of trypsin-like activity of 20S proteasome in rabbit erythrocytes using Boc-LRR-AMC as substrate preincubated for 15 mins measured after 45 mins by fluorescence assay
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
C1 and N5 derivatives of cerpegin: synthesis of a new series based on structure-activity relationships to optimize their inhibitory effect on 20S proteasome.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 7.68 | 7.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL371405 | MARIZOMIB | 3.0 | 1 | 7.68 |
| CHEMBL2376187 | — | — | 1 | - |
| CHEMBL2376183 | — | — | 1 | - |
| CHEMBL2376182 | — | — | 1 | - |
| CHEMBL2376181 | — | — | 1 | - |
| CHEMBL2376180 | — | — | 1 | - |
| CHEMBL2376179 | — | — | 1 | - |
| CHEMBL2376296 | — | — | 1 | - |
| CHEMBL2376295 | — | — | 1 | - |
| CHEMBL2376294 | — | — | 1 | - |
| CHEMBL2376293 | — | — | 1 | - |
| CHEMBL2376292 | — | — | 1 | - |
| CHEMBL2376291 | — | — | 1 | - |
| CHEMBL2376290 | — | — | 1 | - |
| CHEMBL2376288 | — | — | 1 | - |
| CHEMBL2376297 | — | — | 1 | - |
| CHEMBL2376188 | — | — | 1 | - |
| CHEMBL2376189 | — | — | 1 | - |
| CHEMBL2376277 | — | — | 1 | - |
| CHEMBL2376278 | — | — | 1 | - |
| CHEMBL2376279 | — | — | 1 | - |
| CHEMBL2376289 | — | — | 1 | - |
| CHEMBL2376281 | — | — | 1 | - |
| CHEMBL2376282 | — | — | 1 | - |
| CHEMBL2376283 | — | — | 1 | - |
| CHEMBL2376284 | — | — | 1 | - |
| CHEMBL2376285 | — | — | 1 | - |
| CHEMBL2376286 | — | — | 1 | - |
| CHEMBL2376287 | — | — | 1 | - |
| CHEMBL2376280 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL371405 | MARIZOMIB | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL2376179 | — | IC50 | - | — | - | |
| CHEMBL2376290 | — | IC50 | - | — | - | |
| CHEMBL2376291 | — | IC50 | - | — | - | |
| CHEMBL2376292 | — | IC50 | - | — | - | |
| CHEMBL2376293 | — | IC50 | - | — | - | |
| CHEMBL2376294 | — | IC50 | - | — | - | |
| CHEMBL2376295 | — | IC50 | - | — | - | |
| CHEMBL2376296 | — | IC50 | - | — | - | |
| CHEMBL2376297 | — | IC50 | - | — | - | |
| CHEMBL2376180 | — | IC50 | - | — | - | |
| CHEMBL2376181 | — | IC50 | - | — | - | |
| CHEMBL2376182 | — | IC50 | - | — | - | |
| CHEMBL2376183 | — | IC50 | - | — | - | |
| CHEMBL2376184 | — | IC50 | - | — | - | |
| CHEMBL2376185 | — | IC50 | - | — | - | |
| CHEMBL2376186 | — | IC50 | - | — | - | |
| CHEMBL2376288 | — | IC50 | - | — | - | |
| CHEMBL2376187 | — | IC50 | - | — | - | |
| CHEMBL2376188 | — | IC50 | - | — | - | |
| CHEMBL2376189 | — | IC50 | - | — | - | |
| CHEMBL2376277 | — | IC50 | - | — | - | |
| CHEMBL2376278 | — | IC50 | - | — | - | |
| CHEMBL2376279 | — | IC50 | - | — | - | |
| CHEMBL2376289 | — | IC50 | - | — | - | |
| CHEMBL2376281 | — | IC50 | - | — | - | |
| CHEMBL2376282 | — | IC50 | - | — | - | |
| CHEMBL2376283 | — | IC50 | - | — | - | |
| CHEMBL2376284 | — | IC50 | - | — | - | |
| CHEMBL2376285 | — | IC50 | - | — | - | |
| CHEMBL2376286 | — | IC50 | - | — | - | |
| CHEMBL2376287 | — | IC50 | - | — | - | |
| CHEMBL2376280 | — | IC50 | - | — | - |