Assay Detail
Binding
CHEMBL2379284
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Displacement of [3H]-8-OH-DPAT from 5HT1A receptor in rat hippocampal membranes after 20 mins
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Hippocampus |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of novel pyrrolidine-2,5-dione derivatives as potential antidepressant agents. Part 1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 26 | 7.20 | 8.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL39 | SEROTONIN | 3.0 | 1 | 8.68 |
| CHEMBL2377591 | — | — | 1 | 8.66 |
| CHEMBL2377578 | — | — | 1 | 8.49 |
| CHEMBL2377590 | — | — | 1 | 8.12 |
| CHEMBL2377445 | — | — | 1 | 8.09 |
| CHEMBL2377574 | — | — | 1 | 7.90 |
| CHEMBL2377589 | — | — | 1 | 7.80 |
| CHEMBL2377577 | — | — | 1 | 7.75 |
| CHEMBL2377443 | — | — | 1 | 7.49 |
| CHEMBL2377576 | — | — | 1 | 7.23 |
| CHEMBL2377575 | — | — | 1 | 7.16 |
| CHEMBL2377592 | — | — | 1 | 7.16 |
| CHEMBL2377582 | — | — | 1 | 6.97 |
| CHEMBL2377581 | — | — | 1 | 6.96 |
| CHEMBL2377442 | — | — | 1 | 6.92 |
| CHEMBL2377579 | — | — | 1 | 6.79 |
| CHEMBL2377583 | — | — | 1 | 6.68 |
| CHEMBL2377584 | — | — | 1 | 6.60 |
| CHEMBL2377580 | — | — | 1 | 6.54 |
| CHEMBL2377586 | — | — | 1 | 6.49 |
| CHEMBL2377446 | — | — | 1 | 6.45 |
| CHEMBL2377444 | — | — | 1 | 6.44 |
| CHEMBL2377587 | — | — | 1 | 6.43 |
| CHEMBL2377585 | — | — | 1 | 6.39 |
| CHEMBL2377588 | — | — | 1 | 5.76 |
| CHEMBL41 | FLUOXETINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL39 | SEROTONIN | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL2377591 | — | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL2377578 | — | Ki | = | 3.2 | nM | 8.49 |
| CHEMBL2377590 | — | Ki | = | 7.5 | nM | 8.12 |
| CHEMBL2377445 | — | Ki | = | 8.1 | nM | 8.09 |
| CHEMBL2377574 | — | Ki | = | 12.5 | nM | 7.90 |
| CHEMBL2377589 | — | Ki | = | 15.7 | nM | 7.80 |
| CHEMBL2377577 | — | Ki | = | 17.6 | nM | 7.75 |
| CHEMBL2377443 | — | Ki | = | 32.6 | nM | 7.49 |
| CHEMBL2377576 | — | Ki | = | 59.1 | nM | 7.23 |
| CHEMBL2377575 | — | Ki | = | 68.7 | nM | 7.16 |
| CHEMBL2377592 | — | Ki | = | 68.5 | nM | 7.16 |
| CHEMBL2377582 | — | Ki | = | 106.3 | nM | 6.97 |
| CHEMBL2377581 | — | Ki | = | 110.8 | nM | 6.96 |
| CHEMBL2377442 | — | Ki | = | 121.6 | nM | 6.92 |
| CHEMBL2377579 | — | Ki | = | 161.4 | nM | 6.79 |
| CHEMBL2377583 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL2377584 | — | Ki | = | 249.5 | nM | 6.60 |
| CHEMBL2377580 | — | Ki | = | 285.2 | nM | 6.54 |
| CHEMBL2377586 | — | Ki | = | 323.8 | nM | 6.49 |
| CHEMBL2377446 | — | Ki | = | 351.7 | nM | 6.45 |
| CHEMBL2377444 | — | Ki | = | 364.4 | nM | 6.44 |
| CHEMBL2377587 | — | Ki | = | 371.7 | nM | 6.43 |
| CHEMBL2377585 | — | Ki | = | 406.0 | nM | 6.39 |
| CHEMBL2377588 | — | Ki | = | 1740.4 | nM | 5.76 |
| CHEMBL41 | FLUOXETINE | Ki | - | — | - |