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Assay Detail

CHEMBL2379323

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Cytotoxicity against human MT4 cells by CellTitre-Glo luminescent assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Homo sapiens
Cell Type MT4
Confidence 1 — Organism
Curated By Autocuration

Target

MT4 (CHEMBL388)
Type CELL-LINE
Organism Homo sapiens

Publication

Isolation, structure determination, and anti-HIV evaluation of tigliane-type diterpenes and biflavonoid from Stellera chamaejasme.
Asada Y, Sukemori A, Watanabe T, Malla KJ, Yoshikawa T, Li W, Kuang X, Koike K, Chen CH, Akiyama T, Qian K, Nakagawa-Goto K, Morris-Natschke SL, Lu Y, Lee KH.
J Nat Prod (2013) 76 : 852 -857
PubMed 23611151 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 11 5.13 5.46

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2375489 1 5.46
CHEMBL501600 GNIDIMACRIN 1 5.37
CHEMBL2375496 1 5.37
CHEMBL1096216 1 5.36
CHEMBL2375486 1 5.33
CHEMBL2375485 STELLERARIN 1 5.29
CHEMBL2375487 1 5.11
CHEMBL2375490 1 4.80
CHEMBL2375495 1 4.79
CHEMBL2375491 1 4.76
CHEMBL2375488 1 4.76

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2375489 IC50 = 3500.0 nM 5.46
CHEMBL501600 GNIDIMACRIN IC50 = 4300.0 nM 5.37
CHEMBL2375496 IC50 = 4300.0 nM 5.37
CHEMBL1096216 IC50 = 4400.0 nM 5.36
CHEMBL2375486 IC50 = 4700.0 nM 5.33
CHEMBL2375485 STELLERARIN IC50 = 5100.0 nM 5.29
CHEMBL2375487 IC50 = 7800.0 nM 5.11
CHEMBL2375490 IC50 = 15800.0 nM 4.80
CHEMBL2375495 IC50 = 16200.0 nM 4.79
CHEMBL2375491 IC50 = 17500.0 nM 4.76
CHEMBL2375488 IC50 = 17200.0 nM 4.76