Assay Detail
Binding
CHEMBL2379472
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]LSD from human 5HT6 receptor expressed in HEK cell membranes after 1 hr by liquid scintillation counting analysis
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-activity relationship of 5-chloro-2-methyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole analogues as 5-HT(6) receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 7.26 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2376488 | — | — | 1 | 8.05 |
| CHEMBL2376487 | — | — | 1 | 8.00 |
| CHEMBL2376482 | — | — | 1 | 8.00 |
| CHEMBL26379 | — | — | 1 | 7.70 |
| CHEMBL2376486 | — | — | 1 | 7.70 |
| CHEMBL2376483 | — | — | 1 | 7.52 |
| CHEMBL2376492 | — | — | 1 | 7.40 |
| CHEMBL2376484 | — | — | 1 | 7.30 |
| CHEMBL2376560 | — | — | 1 | 7.10 |
| CHEMBL2376493 | — | — | 1 | 7.00 |
| CHEMBL2376489 | — | — | 1 | 7.00 |
| CHEMBL1550957 | — | — | 1 | 6.70 |
| CHEMBL2376490 | — | — | 1 | 6.16 |
| CHEMBL2376491 | — | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2376488 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL2376487 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL2376482 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL26379 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL2376486 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL2376483 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL2376492 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL2376484 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL2376560 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL2376493 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL2376489 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL1550957 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL2376490 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL2376491 | — | IC50 | = | 1000.0 | nM | 6.00 |