Compound Detail
CHEMBL2376486
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Basic Information
| ChEMBL ID | CHEMBL2376486 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | PYXFRMLACHDGND-UHFFFAOYSA-N |
1
Targets
2
Activities
2
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
258.4
MW (Da)
3.57
ALogP
2
HBA
2
HBD
27.8
PSA (Ų)
0.81
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 8.18
IC50 1 meas. best 7.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 6 CHEMBL3371 | EC50 | 8.18 | 8.18 | 6.6 | 1 |
| 5-hydroxytryptamine receptor 6 CHEMBL3371 | IC50 | 7.7 | 7.7 | 20.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 6 | EC50 | = | 6.6 | nM | 8.18 | Partial agonist activity at human 5HT6 receptor expressed in BHK cells assessed ... | 23542166 |
| 5-hydroxytryptamine receptor 6 | IC50 | = | 20.0 | nM | 7.7 | Displacement of [3H]LSD from human 5HT6 receptor expressed in HEK cell membranes... | 23542166 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 23542166 | 10.1016/j.ejmech.2013.03.006 | 5-hydroxytryptamine receptor 6 | 3 |
Data from ChEMBL 36 via Core Engine