Assay Detail
Binding
CHEMBL2379698
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Binding affinity to rat histamine H4 receptor
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A novel series of histamine H4 receptor antagonists based on the pyrido[3,2-d]pyrimidine scaffold: comparison of hERG binding and target residence time with PF-3893787.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 7.27 | 7.56 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2376803 | — | — | 1 | 7.56 |
| CHEMBL2376804 | — | — | 1 | 7.53 |
| CHEMBL1915540 | ADRIFORANT | 2.0 | 1 | 7.26 |
| CHEMBL2376800 | — | — | 1 | 7.15 |
| CHEMBL2376801 | — | — | 1 | 6.86 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2376803 | — | Ki | = | 27.54 | nM | 7.56 |
| CHEMBL2376804 | — | Ki | = | 29.51 | nM | 7.53 |
| CHEMBL1915540 | ADRIFORANT | Ki | = | 54.95 | nM | 7.26 |
| CHEMBL2376800 | — | Ki | = | 70.79 | nM | 7.15 |
| CHEMBL2376801 | — | Ki | = | 138.04 | nM | 6.86 |