Assay Detail
Binding
CHEMBL2379709
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of JNK3-mediated c-Jun phosphorylation in rat INS-1 cells after 3 hrs by ELISA
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | INS1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Mitogen-activated protein kinase 10 (CHEMBL4092) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Design and synthesis of 1-aryl-5-anilinoindazoles as c-Jun N-terminal kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.34 | 5.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2376915 | — | — | 1 | 5.39 |
| CHEMBL2376930 | — | — | 1 | 5.28 |
| CHEMBL2376906 | — | — | 1 | - |
| CHEMBL2376922 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2376915 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL2376930 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL2376906 | — | IC50 | >= | 20000.0 | nM | - |
| CHEMBL2376922 | — | IC50 | >= | 20000.0 | nM | - |