Assay Detail
Binding
CHEMBL2379717
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Inhibition of MAPK p38 (unknown origin)-mediated ATF2 Thr71 phosphorylation by HTRF assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Design and synthesis of 1-aryl-5-anilinoindazoles as c-Jun N-terminal kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.93 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2376914 | — | — | 1 | 7.75 |
| CHEMBL1233748 | — | — | 1 | 7.52 |
| CHEMBL2376915 | — | — | 1 | 7.40 |
| CHEMBL2376905 | — | — | 1 | 6.85 |
| CHEMBL2376906 | — | — | 1 | 6.77 |
| CHEMBL2376928 | — | — | 1 | 6.32 |
| CHEMBL2376930 | — | — | 1 | 5.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2376914 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL1233748 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL2376915 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL2376905 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL2376906 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL2376928 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL2376930 | — | IC50 | = | 1300.0 | nM | 5.89 |