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Assay Detail

CHEMBL2379720

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of JNK3 (unknown origin)-mediated ATF2 Thr71 phosphorylation by HTRF assay
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Mitogen-activated protein kinase 10 (CHEMBL2637)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Design and synthesis of 1-aryl-5-anilinoindazoles as c-Jun N-terminal kinase inhibitors.
Jiang R, Frackowiak B, Shin Y, Song X, Chen W, Lin L, Cameron MD, Duckett DR, Kamenecka TM.
Bioorg Med Chem Lett (2013) 23 : 2683 -2687
PubMed 23518277 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 28 7.13 8.05

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1233748 1 8.05
CHEMBL2376910 1 7.92
CHEMBL2376919 1 7.82
CHEMBL2376918 1 7.66
CHEMBL2376909 1 7.62
CHEMBL2376913 1 7.50
CHEMBL2376906 1 7.48
CHEMBL2376922 1 7.46
CHEMBL2376914 1 7.42
CHEMBL2376926 1 7.40
CHEMBL2376917 1 7.37
CHEMBL2376911 1 7.34
CHEMBL2376925 1 7.30
CHEMBL2376915 1 7.27
CHEMBL2376912 1 7.23
CHEMBL2376924 1 7.20
CHEMBL2376916 1 7.11
CHEMBL2376931 1 7.10
CHEMBL2376929 1 6.96
CHEMBL2376920 1 6.92
CHEMBL2376930 1 6.92
CHEMBL2376905 1 6.77
CHEMBL2376921 1 6.60
CHEMBL2376927 1 6.19
CHEMBL2376928 1 6.19
CHEMBL2376907 1 5.96
CHEMBL2376923 1 5.85
CHEMBL2376908 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1233748 IC50 = 9.0 nM 8.05
CHEMBL2376910 IC50 = 12.0 nM 7.92
CHEMBL2376919 IC50 = 15.0 nM 7.82
CHEMBL2376918 IC50 = 22.0 nM 7.66
CHEMBL2376909 IC50 = 24.0 nM 7.62
CHEMBL2376913 IC50 = 32.0 nM 7.50
CHEMBL2376906 IC50 = 33.0 nM 7.48
CHEMBL2376922 IC50 = 35.0 nM 7.46
CHEMBL2376914 IC50 = 38.0 nM 7.42
CHEMBL2376926 IC50 = 40.0 nM 7.40
CHEMBL2376917 IC50 = 43.0 nM 7.37
CHEMBL2376911 IC50 = 46.0 nM 7.34
CHEMBL2376925 IC50 = 50.0 nM 7.30
CHEMBL2376915 IC50 = 54.0 nM 7.27
CHEMBL2376912 IC50 = 59.0 nM 7.23
CHEMBL2376924 IC50 = 63.0 nM 7.20
CHEMBL2376916 IC50 = 77.0 nM 7.11
CHEMBL2376931 IC50 = 80.0 nM 7.10
CHEMBL2376929 IC50 = 110.0 nM 6.96
CHEMBL2376920 IC50 = 120.0 nM 6.92
CHEMBL2376930 IC50 = 120.0 nM 6.92
CHEMBL2376905 IC50 = 170.0 nM 6.77
CHEMBL2376921 IC50 = 250.0 nM 6.60
CHEMBL2376927 IC50 = 640.0 nM 6.19
CHEMBL2376928 IC50 = 640.0 nM 6.19
CHEMBL2376907 IC50 = 1100.0 nM 5.96
CHEMBL2376923 IC50 = 1400.0 nM 5.85
CHEMBL2376908 IC50 > 20000.0 nM -